All Outputs (3)

Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide (2014)
Journal Article
Wong, P. S., Roberts, R. E., & Randall, M. D. (2015). Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide. Pharmacological Research, 91, https://doi.org/10.1016/j.phrs.2014.11.001

Oxygenation with 95%O2is routinely used in organ bath studies. However, hyperoxia may affect tissueresponses, particularly in studies which involve reactive oxygen species (ROS). Here, the effects of theantioxidant, Tiron, were investigated under dif... Read More about Hyperoxic gassing with Tiron enhances bradykinin-induced endothelium-dependent and EDH-type relaxation through generation of hydrogen peroxide.

A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article
Wong, P., Garle, M., Alexander, S., Randall, M., & Roberts, R. (2014). A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological Research, 90, https://doi.org/10.1016/j.phrs.2014.09.004

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions? (2014)
Journal Article
Wong, P., Roberts, R., & Randall, M. (2014). Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?. British Journal of Pharmacology, 171(11), https://doi.org/10.1111/bph.12595

BACKGROUND AND PURPOSE: Cardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in endothelial function. Here, sex differences in endothelial function of porcine coronary art... Read More about Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?.