Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe

Brown, William R.A.; Thomas, Geraint; Lee, Nicholas C.O.; Blythe, Martin; Liti, Gianni; Warringer, Jonas; Loose, Matthew W.

doi:10.1073/pnas.1216934111

All Outputs (5)

Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos (2014)
Journal Article
Chatfield, J., O'Reilly, M., Bachvarova, R. F., Ferjentsik, Z., Redwood, C., Walmsley, M., …JOhnson, A. D. (2014). Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos. Development, 141(12), 2429-2440. https://doi.org/10.1242/dev.105346

A common feature of development in most vertebrate models is the early segregation of the germ line from the soma. For example, in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm that is inherited from the egg;... Read More about Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos.

Transient Accumulation of 5-Carboxylcytosine Indicates Involvement of Active Demethylation in Lineage Specification of Neural Stem Cells (2014)
Journal Article
Wheldon, L. M., Abakir, A., Ferjentsik, Z., Dudnakova, T., Strohbuecker, S., Christie, D., …Ruzov, A. (2014). Transient Accumulation of 5-Carboxylcytosine Indicates Involvement of Active Demethylation in Lineage Specification of Neural Stem Cells. Cell Reports, 7(5), 1353-1361. https://doi.org/10.1016/j.celrep.2014.05.003

5-Methylcytosine (5mC) is an epigenetic modification involved in regulation of gene activity during differentiation. Tet dioxygenases oxidize 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Both 5fC and 5... Read More about Transient Accumulation of 5-Carboxylcytosine Indicates Involvement of Active Demethylation in Lineage Specification of Neural Stem Cells.

Acquisition of Germ Plasm Accelerates Vertebrate Evolution (2014)
Journal Article
Evans, T., Wade, C. M., Chapman, F. A., Johnson, A. D., & Loose, M. (2014). Acquisition of Germ Plasm Accelerates Vertebrate Evolution. Science, 344(6180), 200-203. https://doi.org/10.1126/science.1249325

Dissection of a Ciona regulatory element reveals complexity of cross-species enhancer activity (2014)
Journal Article
Chen, W., Pauls, S., Bacha, J., Elgar, G., Loose, M., & Shimeld, S. (2014). Dissection of a Ciona regulatory element reveals complexity of cross-species enhancer activity. Developmental Biology, 390(2), 261-272. https://doi.org/10.1016/j.ydbio.2014.03.013

Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe (2014)
Journal Article
Brown, W. R., Thomas, G., Lee, N. C., Blythe, M., Liti, G., Warringer, J., & Loose, M. W. (2014). Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences, 111(5), https://doi.org/10.1073/pnas.1216934111

Kinetochores in multicellular eukaryotes are usually associated with heterochromatin. Whether this heterochromatin simply promotes the cohesion necessary for accurate chromosome segregation at cell division or whether it also has a role in kinetochor... Read More about Kinetochore assembly and heterochromatin formation occur autonomously in Schizosaccharomyces pombe.