All Outputs (7)

Can a simple outpatient-based treatment be used to treat cutaneous leishmaniasis in young children? A critically appraised topic (2014)
Journal Article
Burden-Teh, E., Wooton, C., & Williams, H. (2015). Can a simple outpatient-based treatment be used to treat cutaneous leishmaniasis in young children? A critically appraised topic. British Journal of Dermatology, 172(4), 861-866. doi:10.1111/bjd.13496

A 5‐year‐old boy from rural Afghanistan presented with a 1‐year history of a skin lesion on his left knee, confirmed by polymerase chain reaction to be cutaneous leishmaniasis (Leishmania tropica). Conventional treatment of cutaneous leishmaniasis in... Read More about Can a simple outpatient-based treatment be used to treat cutaneous leishmaniasis in young children? A critically appraised topic.

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention (2014)
Journal Article
Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., Irwin McLean, W., …Williams, H. C. (2014). Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. Journal of Allergy and Clinical Immunology, 134(4), 818-823. https://doi.org/10.1016/j.jaci.2014.08.005

Atopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and is increasing in prevalence. Because of the significant socioeconomic effect of atopic dermatitis and its effect... Read More about Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention.

The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials (2014)
Journal Article
Schmitt, J., Spuls, P. I., Thomas, K. S., Simpson, E., Furue, M., Deckert, S., …Williams, H. C. (2014). The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials. Journal of Allergy and Clinical Immunology, 134(4), 800-807. https://doi.org/10.1016/j.jaci.2014.07.043

The lack of core outcome sets for atopic eczema (AE) is a major obstacle for advancing evidence-based treatment. The global Harmonising Outcome Measures for Eczema (HOME) initiative has already defined clinical signs, symptoms, quality of life, and l... Read More about The Harmonising Outcome Measures for Eczema (HOME) statement to assess clinical signs of atopic eczema in trials.

Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 (2014)
Journal Article
Wang, H., Liddell, C. A., Coates, M. M., Mooney, M. D., Levitz, C. E., Schumacher, A. E., …Murray, C. J. L. (2014). Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384(9947), 957-979. https://doi.org/10.1016/s0140-6736%2814%2960497-9

Background Remarkable financial and political efforts have been focused on the reduction of child mortality during the past few decades. Timely measurements of levels and trends in under-5 mortality are important to assess progress towards the Mi... Read More about Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.

Rehabilitation aimed at improving outdoor mobility for people after stroke: a multi-centre randomised controlled study (the Getting out of the House Study) (2014)
Journal Article
Logan, P. A., Armstrong, S., Avery, T., Barer, D., Barton, G., Darby, J., …Leighton, M. P. (2014). Rehabilitation aimed at improving outdoor mobility for people after stroke: a multi-centre randomised controlled study (the Getting out of the House Study). Health Technology Assessment, 18(29), 1-73. https://doi.org/10.3310/hta18290

Background: One-third of stroke patients are dependent on others to get outside their homes. This can cause people to become housebound, leading to increased immobility, poor health, isolation and misery. There is some evidence that outdoor mobility... Read More about Rehabilitation aimed at improving outdoor mobility for people after stroke: a multi-centre randomised controlled study (the Getting out of the House Study).

Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection (2014)
Journal Article
Elliker, K. R., Armstrong, S., Sommerville, B. A., Broom, D. M., Neal, D. E., & Williams, H. C. (2014). Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection. BMC Urology, 14(1), 1-9. https://doi.org/10.1186/1471-2490-14-22

Background: Cancer detection using sniffer dogs is a potential technology for clinical use and research. Our study sought to determine whether dogs could be trained to discriminate the odour of urine from men with prostate cancer from controls, using... Read More about Key considerations for the experimental training and evaluation of cancer odour detection dogs: lessons learnt from a double-blind, controlled trial of prostate cancer detection.

Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials. (2014)
Journal Article
Mason, J. M., Thomas, K., Crook, A. M., Foster, K. A., Chalmers, J., Nunn, A. J., & Williams, H. C. (2014). Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials. PLoS ONE, 9(2), https://doi.org/10.1371/journal.pone.0082694

Background Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. We assessed the cost-effectiveness of prophylactic antibiotic treatment to prevent the recurrence of cellulitis using low dose... Read More about Prophylactic antibiotics to prevent cellulitis of the leg: economic analysis of the PATCH I & II trials..