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Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag (2014)
Journal Article
Hage, N., Falcone, F., Renshaw, J. G., Sebastiaan Winkler, G., Gellert, P., & Stolnik, S. (2015). Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag. Protein Expression and Purification, 106, 25-30. doi:10.1016/j.pep.2014.10.009

Helicobacter pylori is a pathogenic bacterium that has the remarkable ability to withstand the harsh conditions of the stomach for decades. This is achieved through unique evolutionary adaptations, which include binding Lewisb antigens found on the g... Read More about Improved expression and purification of the Helicobacter pylori adhesin BabA through the incorporation of a hexa-lysine tag.

Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins (2014)
Journal Article
Alcocer, M., Wan, D., Ludolf, F., Alanine, D. G. W., Stretton, O., Ali Ali, E., …Falcone, F. H. (2014). Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins. PLoS Neglected Tropical Diseases, 8(9), 1-13. https://doi.org/10.1371/journal.pntd.0003124

Background Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE response in S. mansoni infection have been characterised. A better insight into... Read More about Use of humanised rat basophilic leukaemia cell line RSATL8 for the assessment of allergenicity of Schistosoma mansoni proteins.

High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites (2014)
Journal Article
Manno, N., Sherratt, S., Boaretto, F., Mejìa Coico, F., Espinoza Camus, C., Jara Campos, C., …Falcone, F. (2014). High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites. Carbohydrate Polymers, 113, 607-614. https://doi.org/10.1016/j.carbpol.2014.07.011

The human genome encodes a gene for an enzymatically active chitinase (CHIT1) located in a single copy on Chromosome 1, which is highly expressed by activated macrophages and in other cells of the innate immune response. Several dysfunctional mutatio... Read More about High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites.

Serological screening of the Schistosoma mansoni adult worm proteome (2014)
Journal Article
Falcone, F., Ludolf, F., Patrocínio, P. R., Corrêa-Oliveira, R., Gazzinelli, A., Teixeira-Ferreira, A., …Silva-Pereira, R. A. (2014). Serological screening of the Schistosoma mansoni adult worm proteome. PLoS Neglected Tropical Diseases, 8(3), 1-16. https://doi.org/10.1371/journal.pntd.0002745

Background New interventions tools are a priority for schistosomiasis control and elimination, as the disease is still highly prevalent. The identification of proteins associated with active infection and protective immune response may constitute th... Read More about Serological screening of the Schistosoma mansoni adult worm proteome.

Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules (2014)
Journal Article
Stolnik-Trenkic, S., Vllasaliua, D., Falcone, F. H., & Garnett, M. (2014). Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules. Experimental Cell Research, 323(1), 218-231. https://doi.org/10.1016/j.yexcr.2014.02.022

This work examines the potential drug delivery barrier of the basement membrane (BM) by assessing the permeability of select macromolecules and nanoparticles. The study further extends to probing the effect of BM on intestinal epithelial cell attachm... Read More about Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules.