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Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation (2014)
Journal Article
Gatland, A. E., Pilgrim, B. S., Procopiou, P. A., & Donohoe, T. J. (2014). Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation. Angewandte Chemie International Edition, 53(52), 14555-14558. https://doi.org/10.1002/anie.201409164

A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile palladium?catalyzed enolate arylation is used to form the isoquinoline core. The overall yield of 50?% is a large improvement over the single, previous syn... Read More about Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium-Catalyzed Enolate Arylation.