A role for Na+,K+-ATPase ?1 in regulating Rab27a localisation on melanosomes

Seabra, Miguel C.; Tarafder, Abul K.; Booth, Antonia E.G.; Hume, Alistair N.; Recchi, Chiara

doi:10.1371/journal.pone.0102851

All Outputs (4)

A role for Rab27 in neutrophil chemotaxis and lung recruitment (2014)
Journal Article
Seabra, M. C., Rankin, S. M., Birrell, M. A., Furze, R. C., Singh, R. K., & Hume, A. N. (2014). A role for Rab27 in neutrophil chemotaxis and lung recruitment. BMC Cell Biology, 15(1), https://doi.org/10.1186/s12860-014-0039-z

© 2014 Singh et al. Background: Neutrophils are a critical part of the innate immune system. Their ability to migrate into infected or injured tissues precedes their role in microbial killing and clearance. We have previously shown that Rab27a can pr... Read More about A role for Rab27 in neutrophil chemotaxis and lung recruitment.

Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise (2014)
Journal Article
Hume, A. N., & Seabra, M. C. (2014). Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise. Pigment Cell and Melanoma Research, 27(6), 1012-1013. https://doi.org/10.1111/pcmr.12310

Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport (2014)
Journal Article
Evans, R. D., Robinson, C., Briggs, D. A., Tooth, D. J., Ramalho, J. S., Cantero, M., …Hume, A. N. (2014). Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport. Current Biology, 24(15), 1743-1750. https://doi.org/10.1016/j.cub.2014.06.019

In animal cells, microtubule and actin tracks and their associated motors (dynein, kinesin, and myosin) are thought to regulate long- and short-range transport, respectively [1-8]. Consistent with this, microtubules extend from the perinuclear centro... Read More about Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport.

A role for Na+,K+-ATPase ?1 in regulating Rab27a localisation on melanosomes (2014)
Journal Article
Seabra, M. C., Tarafder, A. K., Booth, A. E., Hume, A. N., & Recchi, C. (2014). A role for Na+,K+-ATPase ?1 in regulating Rab27a localisation on melanosomes. PLoS ONE, 9(7), https://doi.org/10.1371/journal.pone.0102851

The mechanism(s) by which Rab GTPases are specifically recruited to distinct intracellular membranes remains elusive. Here we used Rab27a localisation onto melanosomes as a model to investigate Rab targeting. We identified the α1 subunit of Na+,K+-AT... Read More about A role for Na+,K+-ATPase ?1 in regulating Rab27a localisation on melanosomes.