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A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans (2013)
Journal Article
Wilkinson, D. J., Franchi, M. V., Brook, M. S., Narici, M. V., Williams, J. P., Mitchell, W. K., …Smith, K. (2014). A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans. AJP - Endocrinology and Metabolism, 306(5), Article E571-E579. https://doi.org/10.1152/ajpendo.00650.2013

Quantification of muscle protein synthesis (MPS) remains a cornerstone for understanding the control of muscle mass. Traditional [13C]amino acid tracer methodologies necessitate sustained bed rest and intravenous cannulation(s), restricting studies t... Read More about A validation of the application of D2O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.

Surgical resection of primary tumour improves aerobic performance in colorectal cancer (2013)
Journal Article
Williams, J. P., Nyasavajjala, S. M., Phillips, B. E., Chakrabarty, M., & Lund, J. N. (2014). Surgical resection of primary tumour improves aerobic performance in colorectal cancer. EJSO - European Journal of Surgical Oncology, 40(2), https://doi.org/10.1016/j.ejso.2013.11.009

Background Colorectal cancer is the third most common cancer in the UK, with patients suffering declines in muscle mass and aerobic function. We hypothesised that tumour removal in non-metastatic colorectal cancer would lead to a restoration of le... Read More about Surgical resection of primary tumour improves aerobic performance in colorectal cancer.

Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions (2013)
Journal Article
Phillips, B. E., Atherton, P. J., Varadhan, K., Wilkinson, D. J., Limb, M. C., Selby, A. L., …Williams, J. P. (2014). Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions. AJP - Endocrinology and Metabolism, 306(2), Article E168-E176. https://doi.org/10.1152/ajpendo.00440.2013

Skeletal muscle anabolism associated with postprandial plasma aminoacidemia and insulinemia is contingent upon amino acids (AA) and insulin crossing the microcirculation-myocyte interface. In this study, we hypothesized that increasing muscle microva... Read More about Pharmacological enhancement of leg and muscle microvascular blood flow does not augment anabolic responses in skeletal muscle of young men under fed conditions.

Audit of the autoantibody test, EarlyCDT®-Lung, in 1600 patients: An evaluation of its performance in routine clinical practice (2013)
Journal Article
Jett, J. R., Peek, L. J., Fredericks, L., Jewell, W., Pingleton, W. W., & ROBERTSON, J. (2014). Audit of the autoantibody test, EarlyCDT®-Lung, in 1600 patients: An evaluation of its performance in routine clinical practice. Lung Cancer, 83(1), 51-55. https://doi.org/10.1016/j.lungcan.2013.10.008

Objectives EarlyCDT®-Lung may enhance detection of early stage lung cancer by aiding physicians in assessing high-risk patients through measurement of biological markers (i.e., autoantibodies). The test's performance characteristics in routine clini... Read More about Audit of the autoantibody test, EarlyCDT®-Lung, in 1600 patients: An evaluation of its performance in routine clinical practice.

Substandard and falsified medicines in the UK: a retrospective review of drug alerts (2001-2011) (2013)
Journal Article
Almuzaini, T., Sammons, H., & Choonara, I. (2013). Substandard and falsified medicines in the UK: a retrospective review of drug alerts (2001-2011). BMJ Open, 3(7), Article 10. https://doi.org/10.1136/bmjopen-2013-002924

Objective: To determine the extent of substandard and falsified medicines in the UK. Design: A retrospective review of drug alerts and company-led recalls. Setting: The Medicines and Healthcare Products Regulatory Agency (MHRA) website search fo... Read More about Substandard and falsified medicines in the UK: a retrospective review of drug alerts (2001-2011).

Effects of leucine and its metabolite ?-hydroxy-?-methylbutyrate on human skeletal muscle protein metabolism (2013)
Journal Article
Wilkinson, D., Hossain, T., Hill, D., Phillips, B., Crossland, H., Williams, J., …Atherton, P. (2013). Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism. Journal of Physiology, 591(11), https://doi.org/10.1113/jphysiol.2013.253203

Maintenance of skeletal muscle mass is contingent upon the dynamic equilibrium (fasted losses–fed gains) in protein turnover. Of all nutrients, the single amino acid leucine (Leu) possesses the most marked anabolic characteristics in acting as a trig... Read More about Effects of leucine and its metabolite ?-hydroxy-?-methylbutyrate on human skeletal muscle protein metabolism.

Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study (2013)
Journal Article
John, S. G., Sigrist, M. K., Taal, M. W., & McIntyre, C. W. (2013). Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study. PLoS ONE, 8(5), Article e65372. https://doi.org/10.1371/journal.pone.0065372

Cross-sectional studies in dialysis demonstrate muscle wasting associated with loss of function, increased morbidity and mortality. The relative drivers are poorly understood. There is a paucity of data regarding interval change in muscle in pre-dial... Read More about Natural history of skeletal muscle mass changes in chronic kidney disease stage 4 and 5 patients: an observational study.

Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms (2013)
Journal Article
Vigneswara, V., Cass, S., Wayne, D., Bolt, E. L., Ray, D. E., & Carter, W. (2013). Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms. PLoS ONE, 8(4), Article e61442. https://doi.org/10.1371/journal.pone.0061442

Abnormal ?-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and ?-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of t... Read More about Molecular ageing of alpha- and beta-synucleins: protein damage and repair mechanisms.

Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections (2013)
Journal Article
Pandolfini, C., Kaguelidou, F., Sequi, M., Jacqz-Aigrain, E., Choonara, I., Turner, M. A., …Bonita, M. (2013). Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections. European Journal of Clinical Pharmacology, 69(4), https://doi.org/10.1007/s00228-012-1415-2

Purpose: To describe the use of ciprofloxacin and fluconazole for the treatment of sepsis in European neonatal intensive care units (NICUs) in order to better orient research aimed at acquiring essential knowledge in this critical area. Methods: The... Read More about Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections.

Invasive lobular carcinoma arising in accessory breast tissue (2013)
Journal Article
Devine, C., Courtney, C., Deb, R., & Agrawal, A. (2013). Invasive lobular carcinoma arising in accessory breast tissue. World Journal of Surgical Oncology, 11(47), Article 47. https://doi.org/10.1186/1477-7819-11-47

Background: Lobular carcinoma in accessory breast tissue is a rare occurrence. We present such a case in a 61-year-old woman. Case presentation: A skin nodule in the axillary skin on excision biopsy revealed invasive lobular carcinoma. Conclus... Read More about Invasive lobular carcinoma arising in accessory breast tissue.

An investigation into the spiritual needs of neuro-oncology patients from a nurse perspective (2013)
Journal Article
Nixon, A. V., Narayanasamy, A., & Penny, V. (2013). An investigation into the spiritual needs of neuro-oncology patients from a nurse perspective. BMC Nursing, 12, Article 2. https://doi.org/10.1186/1472-6955-12-2

Background: Spiritual needs of cancer patients should be assessed and discussed by healthcare professionals. Neurosurgical nurses need to be able to assess and support neuro-oncology patients with their spiritual needs from diagnosis and throughout t... Read More about An investigation into the spiritual needs of neuro-oncology patients from a nurse perspective.

Intestinal ischemia following laparoscopic surgery: a case series (2013)
Journal Article
Al-Khyatt, W., Thomas, J. D., Humes, D. J., & Lobo, D. N. (2013). Intestinal ischemia following laparoscopic surgery: a case series. Journal of Medical Case Reports, 7(25), Article 25. https://doi.org/10.1186/1752-1947-7-25

Introduction: Intestinal ischemia is a rare complication of laparoscopic surgery. Its prognosis depends on a high index of suspicion and effective early treatment. Case presentation: In the present report, we describe three cases where intestinal i... Read More about Intestinal ischemia following laparoscopic surgery: a case series.

Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review (2013)
Journal Article
Al-Khyatt, W., Aggarwal, S., Birchall, J., & Rowlands, T. E. (2013). Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review. World Journal of Emergency Surgery, 8(5), Article 5. https://doi.org/10.1186/1749-7922-8-5

Introduction: An internal hernia is a protrusion of bowel through a normal or abnormal orifice in the peritoneum or mesentery. Although they are considered as a rare cause of intestinal obstruction, paraduodenal hernias are the most common type of... Read More about Acute intestinal obstruction secondary to left paraduodenal hernia: a case report and literature review.

Medication errors in the Middle East countries: a systematic review of the literature (2013)
Journal Article
Alsulami, Z., Conroy, S., & Choonara, I. (2013). Medication errors in the Middle East countries: a systematic review of the literature. European Journal of Clinical Pharmacology, 69(4), https://doi.org/10.1007/s00228-012-1435-y

Background: Medication errors are a significant global concern and can cause serious medical consequences for patients. Little is known about medication errors in Middle Eastern countries. The objectives of this systematic review were to review st... Read More about Medication errors in the Middle East countries: a systematic review of the literature.