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Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study (2013)
Journal Article
Dorrington, S., Zammit, S., Asher, L., Evans, J., Heron, J., & Lewis, G. (2014). Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study. Schizophrenia Research, 152(1), 158-163. https://doi.org/10.1016/j.schres.2013.11.006

Background: International studies indicate that the median prevalence of psychotic experiences in children is 7%. It has been proposed that environmental stress during pregnancy may affect the neurodevelopment of the foetus and lead to a vulnerabilit... Read More about Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study.

Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan (2013)
Journal Article
Kuo, C., Grainge, M. J., See, L., Yu, K., Luo, S., Valdes, A. M., …Doherty, M. (2015). Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan. Annals of the Rheumatic Diseases, 74(2), 369-374. https://doi.org/10.1136/annrheumdis-2013-204067

© 2015, BMJ Publishing Group. All rights reserved. Objective: To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Methods: Using data from the Nati... Read More about Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.

Risk factors for wheezing in infants born in Cuba (2013)
Journal Article
Venero-Fernandez, S., Suarez-Medina, R., Mora-Faife, E., Garcia-Garcia, G., Valle-Infante, I., Gomez-Marrero, L., …Fogarty, A. W. (2013). Risk factors for wheezing in infants born in Cuba. QJM: An International Journal of Medicine, 106(11), https://doi.org/10.1093/qjmed/hct143

Background: Cuba is a unique country, and despite limited economic development, has an excellent health system. However, the prevalence of asthma symptoms in children in Havana, Cuba, is unusually high. Aim: As early life exposures are critical t... Read More about Risk factors for wheezing in infants born in Cuba.

Risk of first venous thromboembolism in pregnant women in hospital: population based cohort study from England (2013)
Journal Article
Sultan, A. A., West, J., Tata, L. J., Fleming, K. M., Nelson-Piercy, C., & Grainge, M. J. (2013). Risk of first venous thromboembolism in pregnant women in hospital: population based cohort study from England. BMJ, 347(7935), Article 11. https://doi.org/10.1136/bmj.f6099

Objective: To examine the potential for preventing venous thromboembolism during and after antepartum hospital admissions in pregnant women. Design: Cohort study using linked primary (Clinical Practice Research Datalink) and secondary (Hospital E... Read More about Risk of first venous thromboembolism in pregnant women in hospital: population based cohort study from England.

The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study (2013)
Journal Article
Donaldson, J. W., McKeever, T. M., Hall, I. P., Hubbard, R., & Fogarty, A. W. (2014). The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study. Thorax, 69(2), 161-167. https://doi.org/10.1136/thoraxjnl-2013-203720

Background Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder of aberrant blood vessel development characterised by arteriovenous malformations. HHT is associated with significant morbidity due to complications inc... Read More about The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study.

Using non-invasive biomarkers to identify hepatic fibrosis in people with type 2 diabetes mellitus: The Edinburgh type 2 diabetes study (2013)
Journal Article
Morling, J. R., Fallowfield, J. A., Guha, I. N., Nee, L. D., Glancy, S., Williamson, R. M., …Price, J. F. (2014). Using non-invasive biomarkers to identify hepatic fibrosis in people with type 2 diabetes mellitus: The Edinburgh type 2 diabetes study. Journal of Hepatology, 60(2), 384-391. https://doi.org/10.1016/j.jhep.2013.10.017

Background & Aims It is difficult to determine the different stages of non-alcoholic fatty liver disease without the use of invasive liver biopsy. In this study we investigated five non-invasive biomarkers used previously to detect hepatic fibrosis... Read More about Using non-invasive biomarkers to identify hepatic fibrosis in people with type 2 diabetes mellitus: The Edinburgh type 2 diabetes study.

REFINE (REducing Falls in In-patieNt Elderly) using bed and bedside chair pressure sensors linked to radio-pagers in acute hospital care: a randomised controlled trial (2013)
Journal Article
Sahota, O., Drummond, A., Kendrick, D., Grainge, M. J., Vass, C., Sach, T., …Avis, M. (2014). REFINE (REducing Falls in In-patieNt Elderly) using bed and bedside chair pressure sensors linked to radio-pagers in acute hospital care: a randomised controlled trial. Age and Ageing, 43(2), 247-253. https://doi.org/10.1093/ageing/aft155

Background: falls in hospitals are a major problem and contribute to substantial healthcare burden. Advances in sensor technology afford innovative approaches to reducing falls in acute hospital care. However, whether these are clinically effective a... Read More about REFINE (REducing Falls in In-patieNt Elderly) using bed and bedside chair pressure sensors linked to radio-pagers in acute hospital care: a randomised controlled trial.

Factors Associated With Smoking Cessation in Early and Late Pregnancy in the Smoking, Nicotine, and Pregnancy Trial: A Trial of Nicotine Replacement Therapy (2013)
Journal Article
Vaz, L. R., Leonardi-Bee, J., Aveyard, P., Cooper, S., Grainge, M., & Coleman, T. (2014). Factors Associated With Smoking Cessation in Early and Late Pregnancy in the Smoking, Nicotine, and Pregnancy Trial: A Trial of Nicotine Replacement Therapy. Nicotine and Tobacco Research, 16(4), 381-389. https://doi.org/10.1093/ntr/ntt156

Introduction: Previous studies have found partners’ smoking status, multiparity, and nicotine dependence to be associated with smoking cessation in pregnancy. However, no studies have investigated influences on cessation among women using nicotine re... Read More about Factors Associated With Smoking Cessation in Early and Late Pregnancy in the Smoking, Nicotine, and Pregnancy Trial: A Trial of Nicotine Replacement Therapy.

Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications (2013)
Journal Article
Ban, L., Tata, L. J., Fiaschi, L., & Card, T. R. (2014). Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications. Gastroenterology, 146(1), https://doi.org/10.1053/j.gastro.2013.09.061

Background & aims: Concerns persist about the risk of major congenital anomalies in children of women with inflammatory bowel disease (IBD), and whether medication use affects risk. We assessed these risks, and variations in use of medications by wom... Read More about Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications.

The first recorded outbreak of cryptosporidiosis due to Cryptosporidium cuniculus (formerly rabbit genotype), following a water quality incident (2013)
Journal Article
Puleston, R. L., Mallaghan, C. M., Modha, D. E., Hunter, P. R., Nguyen-Van-Tam, J. S., Regan, C. M., …Chalmers, R. M. (2014). The first recorded outbreak of cryptosporidiosis due to Cryptosporidium cuniculus (formerly rabbit genotype), following a water quality incident. Journal of Water and Health, 12(1), https://doi.org/10.2166/wh.2013.097

Background: We report the first identified outbreak of cryptosporidiosis with Cryptosporidium cuniculus following a water quality incident in Northamptonshire, UK. Methods: A standardised, enhanced Cryptosporidium exposure questionnaire was adminis... Read More about The first recorded outbreak of cryptosporidiosis due to Cryptosporidium cuniculus (formerly rabbit genotype), following a water quality incident.

Completeness of maternal smoking status recording during pregnancy in United Kingdom primary care data (2013)
Journal Article
Dhalwani, N. N., Tata, L. J., Coleman, T., Fleming, K. M., & Szatkowski, L. (2013). Completeness of maternal smoking status recording during pregnancy in United Kingdom primary care data. PLoS ONE, 8(9), Article e72218. https://doi.org/10.1371/journal.pone.0072218

Background: Given the health impacts of smoking during pregnancy and the opportunity for primary healthcare teams to encourage pregnant smokers to quit, we assessed the completeness of gestational smoking status recording in primary care data and inv... Read More about Completeness of maternal smoking status recording during pregnancy in United Kingdom primary care data.

A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery (2013)
Journal Article
Reps, J. M., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. (2014). A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery. IEEE Journal of Biomedical and Health Informatics, 18(2), 537-547. https://doi.org/10.1109/JBHI.2013.2281505

Drugs are frequently prescribed to patients with the aim of improving each patient's medical state, but an unfortunate consequence of most prescription drugs is the occurrence of undesirable side effects. Side effects that occur in more than one in a... Read More about A Novel Semisupervised Algorithm for Rare Prescription Side Effect Discovery.

Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study (2013)
Journal Article
Navaratnam, V., Fogarty, A. W., McKeever, T. M., Thompson, N., Jenkins, G., Johnson, S. R., …Hubbard, R. B. (2014). Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study. Thorax, 69(3), 207-215. https://doi.org/10.1136/thoraxjnl-2013-203740

BACKGROUND: Laboratory studies suggest that the clotting cascade is activated in fibrotic lungs. Since humans vary in their tendency to clot due to a variety of inherited or acquired defects, we investigated whether a prothrombotic state increases th... Read More about Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study.

A systematic review of air pollution as a risk factor for cardiovascular disease in South Asia: Limited evidence from India and Pakistan (2013)
Journal Article
Yamamoto, S., Phalkey, R., & Malik, A. (2014). A systematic review of air pollution as a risk factor for cardiovascular disease in South Asia: Limited evidence from India and Pakistan. International Journal of Hygiene and Environmental Health, 217(2-3), 133-144. doi:10.1016/j.ijheh.2013.08.003

Cardiovascular diseases (CVD) are major contributors to mortality and morbidity in South Asia. Chronic exposure to air pollution is an important risk factor for cardiovascular diseases, although the majority of studies to date have been conducted in... Read More about A systematic review of air pollution as a risk factor for cardiovascular disease in South Asia: Limited evidence from India and Pakistan.

Characterizing tobacco control mass media campaigns in England (2013)
Journal Article
Langley, T., Lewis, S., McNeill, A., Gilmore, A., Szatkowski, L., West, R., & Sims, M. (2013). Characterizing tobacco control mass media campaigns in England. Addiction, 108(11), https://doi.org/10.1111/add.12293

Aims To characterize publically funded tobacco control campaigns in England between 2004 and 2010 and to explore if they were in line with recommendations from the literature in terms of their content and intensity. International evidence suggests t... Read More about Characterizing tobacco control mass media campaigns in England.

Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study (2013)
Journal Article
Manouchehrinia, A., Tench, C. R., Maxted, J., Bibani, R. H., Britton, J., & Constantinescu, C. S. (2013). Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study. Brain, 136(7), https://doi.org/10.1093/brain/awt139

Tobacco smoking has been linked to an increased risk of multiple sclerosis. However, to date, results from the few studies on the impact of smoking on the progression of disability are conflicting. The aim of this study was to investigate the effects... Read More about Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study.

The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis (2013)
Journal Article
Sultan, A. A., Tata, L. J., Grainge, M. J., & West, J. (2013). The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis. PLoS ONE, 8(7), Article e70310. https://doi.org/10.1371/journal.pone.0070310

Background: Recent linkage between primary and secondary care data has provided valuable information for studying heath outcomes that may initially present in different health care settings. The aim of this study was therefore, twofold: to use linke... Read More about The incidence of first venous thromboembolism in and around pregnancy using linked primary and secondary care data: a population based cohort study from England and comparative meta-analysis.

Six-month outcomes following an emergency hospital admission for older adults with co-morbid mental health problems indicate complexity of care needs (2013)
Journal Article
Bradshaw, L., Goldberg, S. E., Lewis, S. A., Whittamore, K., Gladman, J. R., Jones, R. G., & Harwood, R. H. (2013). Six-month outcomes following an emergency hospital admission for older adults with co-morbid mental health problems indicate complexity of care needs. Age and Ageing, 42(5), https://doi.org/10.1093/ageing/aft074

BACKGROUND: two-thirds of older patients admitted as an emergency to a general hospital have co-existing mental health problems including delirium, dementia and depression. This study describes the outcomes of older adults with co-morbid mental heal... Read More about Six-month outcomes following an emergency hospital admission for older adults with co-morbid mental health problems indicate complexity of care needs.

Socioeconomic variations in access to smoking cessation interventions in UK primary care: insights using the Mosaic classification in a large dataset of primary care records (2013)
Journal Article
Douglas, L., & Szatkowski, L. (2013). Socioeconomic variations in access to smoking cessation interventions in UK primary care: insights using the Mosaic classification in a large dataset of primary care records. BMC Public Health, 13(June), Article 7. https://doi.org/10.1186/1471-2458-13-546

Background Smoking prevalence is particularly high amongst more deprived social groups. This cross-sectional study uses the Mosaic classification to explore socioeconomic variations in the delivery and/or uptake of cessation interventions in UK prim... Read More about Socioeconomic variations in access to smoking cessation interventions in UK primary care: insights using the Mosaic classification in a large dataset of primary care records.