Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
(2013)
Journal Article
Hirt, B. V., Wattis, J. A., & Preston, S. P. (2014). Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs. Journal of Mathematical Biology, 68(6), 1521-1552. https://doi.org/10.1007/s00285-013-0678-2
Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length. The enzyme telomerase replenishes the ends... Read More about Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs.