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Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study (2012)
Journal Article
Garrud, P., & Yates, J. (2012). Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study. BMC Medical Education, 12(Decemb), Article 8. https://doi.org/10.1186/1472-6920-12-124

Background 10-15% of students struggle at some point in their medicine course. Risk factors include weaker academic qualifications, male gender, mental illness, UK ethnic minority status, and poor study skills. Recent research on an undergraduate... Read More about Profiling strugglers in a graduate-entry medicine course at Nottingham: a retrospective case study.

Leukotriene B4 receptor locus gene characterisation and association studies in asthma (2012)
Journal Article
Tulah, A. S., Beghé, B., Barton, S. J., Holloway, J. W., & Sayers, I. (2012). Leukotriene B4 receptor locus gene characterisation and association studies in asthma. BMC Medical Genetics, 13(Novemb), Article 11. https://doi.org/10.1186/1471-2350-13-110

Background: Polymorphisms spanning genes involved in the production of leukotriene B4 (LTB4) e.g. ALOX5AP and LTA4H are associated with asthma susceptibility, suggesting a role for LTB4 in disease. The contribution of LTB4 receptor polymorphism is... Read More about Leukotriene B4 receptor locus gene characterisation and association studies in asthma.

Heart rate variability and target organ damage in hypertensive patients (2012)
Journal Article
Melillo, P., Izzo, R., De Luca, N., & Pecchia, L. (2012). Heart rate variability and target organ damage in hypertensive patients. BMC Cardiovascular Disorders, 12(Novemb), Article 11. https://doi.org/10.1186/1471-2261-12-105

Background We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD). Methods A retrospective analysis was performed including 200 patients registered in... Read More about Heart rate variability and target organ damage in hypertensive patients.

Video feedback intervention: a case series in the context of childhood hearing impairment (2012)
Journal Article
James, D. M., Wadnerkar-Kamble, M. B., & Lam-Cassettari, C. (2012). Video feedback intervention: a case series in the context of childhood hearing impairment. International Journal of Language and Communication Disorders, 48(6), https://doi.org/10.1111/1460-6984.12039

Background: Recent research shows that parental sensitivity can explain a significant and unique amount of growth in speech and language outcomes in children with cochlear implants. In this intervention study we explored the impact of an interventi... Read More about Video feedback intervention: a case series in the context of childhood hearing impairment.

Chondrocalcinosis is common in the absence of knee involvement (2012)
Journal Article
Abhishek, A., Doherty, S., Maciewicz, R., Muir, K., Zhang, W., & Doherty, M. (2012). Chondrocalcinosis is common in the absence of knee involvement. Arthritis Research and Therapy, 14(5), Article 5. https://doi.org/10.1186/ar4043

Introduction: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement. Methods: This was... Read More about Chondrocalcinosis is common in the absence of knee involvement.

Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis (2012)
Journal Article
Hurley, M., Cámara, M., & Smyth, A. R. (2012). Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. European Respiratory Journal, 40(4), https://doi.org/10.1183/09031936.00042012

Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action. This review addresses some o... Read More about Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis.

WNT/?-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma (2012)
Journal Article
Rogers, H., Sousa, S., Salto, C., Arenas, E., Coyle, B., & Grundy, R. G. (2012). WNT/?-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma. British Journal of Cancer, 107, https://doi.org/10.1038/bjc.2012.377

Background: Medulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood.... Read More about WNT/?-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.

Computer skills and internet use in adults aged 50-74 years: influence of hearing difficulties (2012)
Journal Article
Henshaw, H., Clark, D. P., Kang, S., & Ferguson, M. A. (2012). Computer skills and internet use in adults aged 50-74 years: influence of hearing difficulties. JMIR, 14(4), Article e113. https://doi.org/10.2196/jmir.2036

BACKGROUND The use of personal computers (PCs) and the Internet to provide health care information and interventions has increased substantially over the past decade. Yet the effectiveness of such an approach is highly dependent upon whether the t... Read More about Computer skills and internet use in adults aged 50-74 years: influence of hearing difficulties.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), 868-875. https://doi.org/10.1038/nbt.2316

Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.

Lactic acidosis secondary to metformin overdose: a case report (2012)
Journal Article
Timbrell, S., Wilbourn, G., Harper, J., & Liddle, A. (2012). Lactic acidosis secondary to metformin overdose: a case report. Journal of Medical Case Reports, 6(230), Article 230. https://doi.org/10.1186/1752-1947-6-230

Introduction Metformin is a commonly used treatment modality in type 2 diabetes mellitus, with a well documented side effect of lactic acidosis. In the intensive care setting lactate and pH levels are regularly used as a useful predictor of poor pro... Read More about Lactic acidosis secondary to metformin overdose: a case report.

Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss (2012)
Journal Article
Adjamian, P., Sereda, M., Zobay, O., Hall, D. A., & Palmer, A. R. (2012). Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss. Journal of the Association for Research in Otolaryngology, 13(5), https://doi.org/10.1007/s10162-012-0340-5

Tinnitus is an auditory phenomenon characterised by the perception of a sound in the absence of an external auditory stimulus. Chronic subjective tinnitus is almost certainly maintained via central mechanisms, and this is consistent with observed mea... Read More about Neuromagnetic indicators of tinnitus and tinnitus masking in patients with and without hearing loss.

Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death (2012)
Journal Article
Rogers, H. A., Kilday, J., Mayne, C., Ward, J., Adamowicz-Brice, M., Schwalbe, E. C., …Grundy, R. G. (2012). Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death. Acta Neuropathologica, 123(5), https://doi.org/10.1007/s00401-011-0904-1

Epigenetic alterations, including methylation, have been shown to be an important mechanism of gene silencing in cancer. Ependymoma has been well characterized at the DNA copy number and mRNA expression levels. However little is known about DNA methy... Read More about Supratentorial and spinal pediatric ependymomas display a hypermethylated phenotype which includes the loss of tumor suppressor genes involved in the control of cell growth and death.

Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data (2012)
Journal Article
Orton, E., Kendrick, D., West, J., & Tata, L. J. (2012). Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data. PLoS ONE, 7(4), Article e35193. https://doi.org/10.1371/journal.pone.0035193

Background: Injuries in childhood are largely preventable yet an estimated 2,400 children die every day because of injury and violence. Despite this, the factors that contribute to injury occurrence have not been quantified at the population scale us... Read More about Independent risk factors for injury in pre-school children: three population-based nested case-control studies using routine primary care data.

Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems (2012)
Journal Article
Jbabdi, S., Sotiropoulos, S. N., Savio, A. M., Graña, M., & Behrens, T. E. (2012). Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems. Magnetic Resonance in Medicine, 68(6), https://doi.org/10.1002/mrm.24204

In this article, we highlight an issue that arises when using multiple b?values in a model?based analysis of diffusion MR data for tractography. The non?monoexponential decay, commonly observed in experimental data, is shown to induce overfitting in... Read More about Model-based analysis of multishell diffusion MR data for tractography: how to get over fitting problems.

CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma (2012)
Journal Article
Smith, S. J., Tilly, H., Ward, J. H., Macarthur, D. C., Lowe, J., Coyle, B., & Grundy, R. G. (2012). CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma. Acta Neuropathologica, 124(1), https://doi.org/10.1007/s00401-012-0952-1

Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focuse... Read More about CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma.

Person centred dementia care: problems and possibilities (2012)
Journal Article
Argyle, E. (2012). Person centred dementia care: problems and possibilities. Working with Older People, 16(2), 69-77. https://doi.org/10.1108/13663661211231828

Purpose Dementia care is an issue of increasing policy focus, with person centred approaches becoming synonymous with quality provision in this area. However, the implementation and efficacy of this approach is difficult to measure and there are s... Read More about Person centred dementia care: problems and possibilities.

Ball and rackets: inferring fiber fanning from diffusion-weighted MRI (2012)
Journal Article
Sotiropoulos, S. N., Behrens, T. E., & Jbabdi, S. (2012). Ball and rackets: inferring fiber fanning from diffusion-weighted MRI. NeuroImage, 60(2), https://doi.org/10.1016/j.neuroimage.2012.01.056

A number of methods have been proposed for resolving crossing fibers from diffusion-weighted (DW) MRI. However, other complex fiber geometries have drawn minimal attention. In this study, we focus on fiber orientation dispersion induced by within-vox... Read More about Ball and rackets: inferring fiber fanning from diffusion-weighted MRI.

Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database (2012)
Journal Article
Vinogradova, Y., Coupland, C., & Hippisley-Cox, J. (2012). Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database. BMJ Open, 2(1), Article e000548. https://doi.org/10.1136/bmjopen-2011-000548

Introduction: Bisphosphonates are becoming a common treatment for osteoporosis particularly after discovery of the association between hormone replacement therapy and increased risk of breast cancer. As osteoporosis develops with age, treatment... Read More about Exposure to bisphosphonates and risk of cancer: a protocol for nested caseecontrol studies using the QResearch primary care database.