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Tissue-specific expression of p73 C-terminal isoforms in mice (2012)
Journal Article
Grespi, F., Amelio, I., Tucci, P., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). Tissue-specific expression of p73 C-terminal isoforms in mice. Cell Cycle, 11(23), 4474-4483. https://doi.org/10.4161/cc.22787

p73 is a p53 family transcription factor. Due to the presence in the 5? flanking region of two promoters, there are two N-terminal variants, TAp73, which retains a fully active transactivation domain (TA), and ?Np73, in which the N terminus is trunca... Read More about Tissue-specific expression of p73 C-terminal isoforms in mice.

Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem (2012)
Journal Article
Beale, K., Gardiner, J., Bewick, G., Hostomska, K., Patel, N., Hussain, S., …Dhillo, W. (2013). Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem. British Journal of Pharmacology, 168(2), 403-410. https://doi.org/10.1111/j.1476-5381.2012.02191.x

Background and Purpose Prokineticin 2 (PK2) has recently been shown to acutely reduce food intake in rodents. We aimed to determine the CNS sites and receptors that mediate the anorectic effects of peripherally administered PK2 and its chronic effect... Read More about Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem.

The “Sharp” blade against HIF-mediated metastasis (2012)
Journal Article
Amelio, I., & Melino, G. (2012). The “Sharp” blade against HIF-mediated metastasis. Cell Cycle, 11(24), 4530-4535. https://doi.org/10.4161/cc.22820

Hypoxia-inducible factors (HIFs) control cellular adaptation to oxygen deprivation. Cancer cells engage HIFs to sustain their growth in adverse conditions, thus promoting a cellular reprograming that includes metabolism, proliferation, survival and m... Read More about The “Sharp” blade against HIF-mediated metastasis.

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium (2012)
Journal Article
Huett, A., Heath, R. J., Begun, J., Sassi, S. O., Baxt, L. A., Vyas, J. M., …Xavier, R. J. (2012). The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium. Cell Host and Microbe, 12(6), 778-790. https://doi.org/10.1016/j.chom.2012.10.019

Several species of pathogenic bacteria replicate within an intracellular vacuolar niche. Bacteria that escape into the cytosol are captured by the autophagic pathway and targeted for lysosomal degradation, representing a defense against bacterial exp... Read More about The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium.

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons (2012)
Journal Article
St Gelais, C., de Silva, S., Amie, S. M., Coleman, C. M., Hoy, H., Hollenbaugh, J. A., …Wu, L. (2012). SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons. Retrovirology, 9(1), https://doi.org/10.1186/1742-4690-9-105

Compartmentalizing the embryo: Lipids and septate junction mediated barrier function (2012)
Journal Article
Ile, K. E., & Renault, A. D. (2013). Compartmentalizing the embryo: Lipids and septate junction mediated barrier function. Fly, 7(1), 18-22. https://doi.org/10.4161/fly.22938

Lipid phosphate phosphatases (LPPs) are a class of enzymes that can dephosphorylate a number of lysophopholipids in vitro. Analysis of knockouts of LPP family members has demonstrated striking but diverse developmental roles for these enzymes. LPP3 i... Read More about Compartmentalizing the embryo: Lipids and septate junction mediated barrier function.

First report of Angiostrongylus cantonensis in the Giant African Land Snail Achatina fulica in French Polynesia detected using the SSU rRNA gene (2012)
Journal Article
Fontanilla, I. K. C., & Wade, C. M. (2012). First report of Angiostrongylus cantonensis in the Giant African Land Snail Achatina fulica in French Polynesia detected using the SSU rRNA gene. Tropical Biomedicine, 29(4), 642-645

The 5' end of the small subunit ribosomal RNA gene was used to determine whether 3rd larval stage Angiostrongylus cantonensis are present in populations of the giant African land snail Achatina fulica from French Polynesia. Two populations, one from... Read More about First report of Angiostrongylus cantonensis in the Giant African Land Snail Achatina fulica in French Polynesia detected using the SSU rRNA gene.

Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering (2012)
Journal Article
Harrington, H. C., Rose, F. R., Reinwald, Y., Buttery, L. D., Ghaemmaghami, A. M., & Aylott, J. W. (2013). Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering. Analytical Methods, 5(1), 68-71. https://doi.org/10.1039/c2ay25771h

Ratiometric analyte responsive nanosensors have been incorporated into electrospun poly(lactic-co-glycolic) acid (PLGA) fibres to create self-reporting scaffolds. It has been demonstrated that the self-reporting scaffolds could be utilised to monitor... Read More about Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering.

Bridging the gap: bitopic ligands of G-protein-coupled receptors (2012)
Journal Article
Lane, J. R., Sexton, P. M., & Christopoulos, A. (2013). Bridging the gap: bitopic ligands of G-protein-coupled receptors. Trends in Pharmacological Sciences, 34(1), 59-66. https://doi.org/10.1016/j.tips.2012.10.003

Although classical approaches to G-protein-coupled receptor (GPCR) drug design have targeted the orthosteric binding site, potentially all GPCRs possess druggable allosteric sites. In addition, it is clear that GPCRs can adopt multiple active states... Read More about Bridging the gap: bitopic ligands of G-protein-coupled receptors.

p63 the guardian of human reproduction (2012)
Journal Article
Amelio, I., Grespi, F., Annicchiarico-Petruzzelli, M., & Melino, G. (2012). p63 the guardian of human reproduction. Cell Cycle, 11(24), 4545-4551. https://doi.org/10.4161/cc.22819

p63 is a transcriptional factor implicated in cancer and development. The presence in TP63 gene of alternative promoters allows expression of one isoform containing the N-terminal transactivation domain (TA isoform) and one N-terminal truncated isofo... Read More about p63 the guardian of human reproduction.

Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase (2012)
Journal Article
Mahdi, A. A., Briggs, G. S., & Lloyd, R. G. (2012). Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase. Molecular Microbiology, 86(3), https://doi.org/10.1111/mmi.12010

RecG is a DNA translocase that helps to maintain genomic integrity. Initial studies suggested a role in promoting recombination, a possibility consistent with synergism between recG and ruv null alleles and reinforced when the protein was shown to un... Read More about Modulation of DNA damage tolerance in Escherichia coli recG and ruv strains by mutations affecting PriB, the ribosome and RNA polymerase.

Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host (2012)
Journal Article
Brown, R. J., Hudson, N., Wilson, G., Rehman, S. U., Jabbari, S., Hu, K., …Ball, J. K. (2012). Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host. Journal of Virology, 86(22), https://doi.org/10.1128/JVI.01079-12

Genetic variability is a hallmark of RNA virus populations. However, transmission to a new host often results in a marked decrease in population diversity. This genetic bottlenecking is observed during hepatitis C virus (HCV) transmission and can ari... Read More about Hepatitis C virus envelope glycoprotein fitness defines virus population composition following transmission to a new host.

Termination and activation of store-operated cyclic AMP production (2012)
Journal Article
Maiellaro, I., Lefkimmiatis, K., Moyer, M. P., Curci, S., & Hofer, A. M. (2012). Termination and activation of store-operated cyclic AMP production. Journal of Cellular and Molecular Medicine, 16(11), 2715-2725. https://doi.org/10.1111/j.1582-4934.2012.01592.x

Diverse pathophysiological processes (e.g. obesity, lifespan determination, addiction and male fertility) have been linked to the expression of specific isoforms of the adenylyl cyclases (AC1‐AC10), the enzymes that generate cyclic AMP (cAMP). Our la... Read More about Termination and activation of store-operated cyclic AMP production.

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration (2012)
Journal Article
Amelio, I., Lena, A. M., Viticchiè, G., Shalom-Feuerstein, R., Terrinoni, A., Dinsdale, D., …Melino, G. (2012). miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration. Journal of Cell Biology, 199(2), 347-363. https://doi.org/10.1083/jcb.201203134

During keratinocyte differentiation and stratification, cells undergo extensive remodeling of their actin cytoskeleton, which is important to control cell mobility and to coordinate and stabilize adhesive structures necessary for functional epithelia... Read More about miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.

Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2 (2012)
Journal Article
Abouseada, N. M., Assafi, M. S. A., Mahdavi, J., Oldfield, N. J., Wheldon, L. M., Wooldridge, K. G., & Ala'Aldeen, D. A. (2012). Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2. PLoS ONE, 7(9), Article 10. https://doi.org/10.1371/journal.pone.0046233

Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae are major bacterial agents of meningitis. They each bind the 37/67-kDa laminin receptor (LamR) via the surface protein adhesins: meningococcal PilQ and PorA, H. influenzae Om... Read More about Mapping the laminin receptor binding domains of Neisseria meningitidis PorA and Haemophilus influenzae OmpP2.

Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity (2012)
Journal Article
Murphy, M., Samms, R., Warner, A., Bolborea, M., Barrett, P., Fowler, M. J., …Ebling, F. J. (2013). Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity. Journal of Neuroendocrinology, 25(2), 180-189. https://doi.org/10.1111/j.1365-2826.2012.02383.x

The present study aimed to investigate the actions of fibroblast growth factor 21 (FGF21) on energy balance in a natural model of relative fatness, the Siberian hamster. Hamsters were studied under long days (LD) to promote weight gain, or short days... Read More about Increased Responses to the Actions of Fibroblast Growth Factor 21 on Energy Balance and Body Weight in a Seasonal Model of Adiposity.

Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells (2012)
Book Chapter
Coleman, C. M., St.Gelais, C., & Wu, L. (2012). Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells. Springer New York. https://doi.org/10.1007/978-1-4614-4433-6_4

Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4+ T cells, the main target of HIV-1 replication. HIV-1 challenged DCs and target CD4+ T... Read More about Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells.

Surface electromyography reveals males have a slower patellar reflex than females (2012)
Journal Article
Vickery, H. S., & Smith, P. A. (2012). Surface electromyography reveals males have a slower patellar reflex than females. Journal of Electro - myography and Kinesiology, 22(6), 990-996. https://doi.org/10.1016/j.jelekin.2012.06.001

In humans the cross sectional area of spinal motor neurons at L3 is larger in males than in females. Since these contribute to the control of the quadriceps femoris muscle group and are involved in the patellar reflex (PR), gender differences in the... Read More about Surface electromyography reveals males have a slower patellar reflex than females.

Conservation of replication timing reveals global and local regulation of replication origin activity (2012)
Journal Article
Müller, C. A., & Nieduszynski, C. A. (2012). Conservation of replication timing reveals global and local regulation of replication origin activity. Genome Research, 22(10), https://doi.org/10.1101/gr.139477.112

DNA replication initiates from defined locations called replication origins; some origins are highly active, whereas others are dormant and rarely used. Origins also differ in their activation time, resulting in particular genomic regions replicating... Read More about Conservation of replication timing reveals global and local regulation of replication origin activity.