All Outputs (5)

Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves (2012)
Journal Article
Thul, R., Coombes, S., & Bootman, M. D. (2012). Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves. Frontiers in Physiology, 3, Article 279. https://doi.org/10.3389/fphys.2012.00279

Clusters of ryanodine receptors within atrial myocytes are confined to spatially separated layers. In many species, these layers are not juxtaposed by invaginations of the plasma membrane (transverse tubules; 'T-tubules'), so that calcium-induced-cal... Read More about Persistence of pro-arrhythmic spatio-temporal calcium patterns in atrial myocytes: a computational study of ping waves.

Interface dynamics in planar neural field models (2012)
Journal Article
Coombes, S., Schmidt, H., & Bojak, I. (2012). Interface dynamics in planar neural field models. Journal of Mathematical Neuroscience, 2(1), 1-46. https://doi.org/10.1186/2190-8567-2-9

Neural field models describe the coarse-grained activity of populations of interacting neurons. Because of the laminar structure of real cortical tissue they are often studied in two spatial dimensions, where they are well known to generate rich patt... Read More about Interface dynamics in planar neural field models.

Using evolutionary algorithms for fitting high-dimensional models to neuronal data (2012)
Journal Article
Svensson, C., Coombes, S., & Peirce, J. (2012). Using evolutionary algorithms for fitting high-dimensional models to neuronal data. Neuroinformatics, 10(2), https://doi.org/10.1007/s12021-012-9140-7

n the study of neurosciences, and of complex biological systems in general, there is frequently a need to fit mathematical models with large numbers of parameters to highly complex datasets. Here we consider algorithms of two different classes, gradi... Read More about Using evolutionary algorithms for fitting high-dimensional models to neuronal data.

Neuronal spike-train responses in the presence of threshold noise (2012)
Journal Article
Coombes, S., Thul, R., Laudanski, J., Palmer, A., & Sumner, C. (in press). Neuronal spike-train responses in the presence of threshold noise. Frontiers in Life Science, 5(3-4), https://doi.org/10.1080/21553769.2011.556016

The variability of neuronal firing has been an intense topic of study for many years. From a modelling perspective it has often been studied in conductance based spiking models with the use of additive or multiplicative noise terms to represent chan... Read More about Neuronal spike-train responses in the presence of threshold noise.

Subcellular calcium dynamics in a whole-cell model of an atrial myocyte (2012)
Journal Article
Thul, R., Coombes, S., Roderick, H. L., & Bootman, M. D. (2012). Subcellular calcium dynamics in a whole-cell model of an atrial myocyte. Proceedings of the National Academy of Sciences, 109(6), 2150-2155. https://doi.org/10.1073/pnas.1115855109

In this study, we present an innovative mathematical modeling approach that allows detailed characterization of Ca 2+ movement within the three-dimensional volume of an atrial myocyte. Essential aspects of the model are the geometrically realistic re... Read More about Subcellular calcium dynamics in a whole-cell model of an atrial myocyte.