All Outputs (3)

Leukotriene B4 receptor locus gene characterisation and association studies in asthma (2012)
Journal Article
Tulah, A. S., Beghé, B., Barton, S. J., Holloway, J. W., & Sayers, I. (2012). Leukotriene B4 receptor locus gene characterisation and association studies in asthma. BMC Medical Genetics, 13(Novemb), Article 11. https://doi.org/10.1186/1471-2350-13-110

Background: Polymorphisms spanning genes involved in the production of leukotriene B4 (LTB4) e.g. ALOX5AP and LTA4H are associated with asthma susceptibility, suggesting a role for LTB4 in disease. The contribution of LTB4 receptor polymorphism is... Read More about Leukotriene B4 receptor locus gene characterisation and association studies in asthma.

Genome-wide association study to identify genetic determinants of severe asthma (2012)
Journal Article
Wan, Y., Shrine, N., Soler Artigas, M., Wain, L., Blakey, J., Moffatt, M., …Hall, I. P. (2012). Genome-wide association study to identify genetic determinants of severe asthma. Thorax, 67(9), https://doi.org/10.1136/thoraxjnl-2011-201262

Background The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild to moderate disease and genetic risk factors for severe asthma remain unclear. Objective To identify co... Read More about Genome-wide association study to identify genetic determinants of severe asthma.

Genetic basis for personalized medicine in asthma (2012)
Journal Article
Portelli, M. A., & Sayers, I. (2012). Genetic basis for personalized medicine in asthma. Expert Review of Respiratory Medicine, 6(2), https://doi.org/10.1586/ers.12.9

There is heterogeneity in patient responses to current asthma medications. Significant progress has been made identifying genetic polymorphisms that influence the efficacy and potential for adverse effects to asthma drugs, including; ?2-adrenergic re... Read More about Genetic basis for personalized medicine in asthma.