All Outputs (3)

A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion (2012)
Journal Article
Guttery, D. S., Poulin, B., Ferguson, D. J. P., Szöőr, B., Wickstead, B., Carroll, P. L., …Tewari, R. (2012). A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathogens, 8(9), Article e1002948. https://doi.org/10.1371/journal.ppat.1002948

Protein phosphorylation and dephosphorylation (catalysed by kinases and phosphatases, respectively) are post-translational modifications that play key roles in many eukaryotic signalling pathways, and are often deregulated in a number of pathological... Read More about A unique protein phosphatase with kelch-like domains (PPKL) in plasmodium modulates ookinete differentiation, motility and invasion.

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development (2012)
Journal Article
Guttery, D. S., Ferguson, D. J. P., Poulin, B., Xu, Z., Straschil, U., Klop, O., …Tewari, R. (2012). A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathogens, 8(2), Article e1002554. https://doi.org/10.1371/journal.ppat.1002554

Cell-cycle progression is governed by a series of essential regulatory proteins. Two major regulators are cell-division cycle protein 20 (CDC20) and its homologue, CDC20 homologue 1 (CDH1), which activate the anaphase-promoting complex/cyclosome (APC... Read More about A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

Effects of ?-synuclein overexpression in transgenic Caenorhabditis elegans strains (2012)
Journal Article
Bodhicharla, R., Nagarajan, A., Winter, J., Adenle, A., Nazir, A., Brady, D., …de Pomerai, D. I. (2012). Effects of α-synuclein overexpression in transgenic Caenorhabditis elegans strains. CNS and Neurological Disorders - Drug Targets, 11(8), https://doi.org/10.2174/1871527311211080005

The neural protein α-synuclein aggregates both in vivo and in vitro to form insoluble fibrils that are involved in Parkinson’s disease pathogenesis. We have generated α-synuclein/fluorescent-protein fusion constructs overexpressed in muscle cells of... Read More about Effects of ?-synuclein overexpression in transgenic Caenorhabditis elegans strains.