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Sustained translational repression by eIF2?-P mediates prion neurodegeneration (2012)
Journal Article
Moreno, J. A., Radford, H., Peretti, D., Steinert, J. R., Verity, N., Martin, M. G., …Mallucci, G. R. (2012). Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature, 485(7399), 507-511. https://doi.org/10.1038/nature11058

The mechanisms leading to neuronal death in neurodegenerative disease are poorly understood. Many of these disorders, including Alzheimer's, Parkinson's and prion diseases, are associated with the accumulation of misfolded disease-specific proteins.... Read More about Sustained translational repression by eIF2?-P mediates prion neurodegeneration.