All Outputs (2)

The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells (2010)
Journal Article
Grundy, M., Seedhouse, C., Shang, S., Richardson, J., Russell, N., & Pallis, M. (2010). The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells. Molecular Cancer Therapeutics, 9(3), https://doi.org/10.1158/1535-7163.MCT-09-1144

Aurora kinases play an essential role in orchestrating chromosome alignment, segregation, and cytokinesis during mitotic progression and both aurora-A and B are frequently overexpressed in a variety of human malignancies. In this study, we report the... Read More about The FLT3 internal tandem duplication mutation is a secondary target of the aurora B kinase inhibitor AZD1152-HQPA in acute myelogenous leukemia cells.

Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis (2010)
Journal Article
Da Costa, C. R., Villadiego, J., Sancho, R., Fontana, X., Packham, G., Nateri, A. S., & Behrens, A. (2010). Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis. Molecular and Cellular Biology, 30(15), 3842-3852. https://doi.org/10.1128/MCB.01610-09

In the nervous system, cell death by apoptosis plays a critical role during normal development and pathological neurodegeneration. Jun N-terminal kinases (JNKs) are essential regulators of neuronal apoptosis. The AP-1 transcription factor c-Jun is ph... Read More about Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.