All Outputs (2)

Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics (2009)
Journal Article
Thul, R., Coombes, S., & Smith, G. (2009). Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics. Physica D: Nonlinear Phenomena, 238, https://doi.org/10.1016/j.physd.2009.08.011

We present a bidomain threshold model of intracellular calcium (Ca²⁺) dynamics in which, as suggested by recent experiments, the cytosolic threshold for Ca²⁺ liberation is modulated by the Ca²⁺ concentration in the releasing compartment. We explicitl... Read More about Sensitisation waves in a bidomain fire-diffuse-fire model of intracellular Ca²⁺ dynamics.

Towards a predictive model of Ca²⁺ puffs (2009)
Journal Article
Thul, R., Thurley, K., & Falcke, M. (2009). Towards a predictive model of Ca²⁺ puffs. Chaos, 19, https://doi.org/10.1063/1.3183809

We investigate key characteristics of Ca²⁺ puffs in deterministic and stochastic frameworks that all incorporate the cellular morphology of IP[subscript]3 receptor channel clusters. In a first step, we numerically study Ca²⁺ liberation in a three dim... Read More about Towards a predictive model of Ca²⁺ puffs.