Skip to main content

Research Repository

Advanced Search

All Outputs (28)

Functional Characterization of AasP, a Maturation Protease Autotransporter Protein of Actinobacillus pleuropneumoniae (2008)
Journal Article
Ali, T., Oldfield, N. J., Wooldridge, K. G., Turner, D. P., & Ala'Aldeen, D. A. A. (2008). Functional Characterization of AasP, a Maturation Protease Autotransporter Protein of Actinobacillus pleuropneumoniae. Infection and Immunity, 76(12), 5608-5614. https://doi.org/10.1128/IAI.00085-08

Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a highly contagious respiratory infection in pigs. AasP, a putative subtilisin-like serine protease autotransporter, has recently been identified in A. pleuropneumon... Read More about Functional Characterization of AasP, a Maturation Protease Autotransporter Protein of Actinobacillus pleuropneumoniae.

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist (2008)
Journal Article
Jaakola, V., Griffith, M. T., Hanson, M. A., Cherezov, V., Chien, E. Y. T., Lane, J. R., …Stevens, R. C. (2008). The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science, 322(5905), 1211-1217. https://doi.org/10.1126/science.1164772

The adenosine class of heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many physiological processes and is antagonized by caffeine. We have determined t... Read More about The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist.

Do humans prefer altruistic mates? Testing a link between sexual selection and altruism towards non-relatives (2008)
Journal Article
Phillips, T., Barnard, C., Ferguson, E., & Reader, T. (2008). Do humans prefer altruistic mates? Testing a link between sexual selection and altruism towards non-relatives. British Journal of Psychology, 99(4), 555-572. https://doi.org/10.1348/000712608X298467

Humans are often seen as unusual in displaying altruistic behaviour towards nonrelatives. Here we outline and test a hypothesis that human altruistic traits evolved as a result of sexual selection. We develop a psychometric scale to measure mate pref... Read More about Do humans prefer altruistic mates? Testing a link between sexual selection and altruism towards non-relatives.

An inside job: Bdellovibrio bacteriovorus (2008)
Journal Article
Sockett, L., Hobley, L., Fenton, A., Woods, R., Lambert, C., Chang, C. Y., …King, S. (2008). An inside job: Bdellovibrio bacteriovorus. Microbiology Today, 35(4), 184-187

The molecular basis of allergenicity (2008)
Journal Article
Shakib, F., Ghaemmaghami, A. M., & Sewell, H. F. (2008). The molecular basis of allergenicity. Trends in Immunology, 29(12), 633-642. https://doi.org/10.1016/j.it.2008.08.007

Allergens are mostly innocuous antigens that elicit powerful T helper cell type 2 (Th2) responses leading to hyper-immunoglobulin E (IgE) production and allergy. Research carried out over several years has highlighted the possible role of the inheren... Read More about The molecular basis of allergenicity.

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant (2008)
Journal Article
Kuballa, P., Huett, A., Rioux, J. D., Daly, M. J., & Xavier, R. J. (2008). Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE, 3(10), Article e3391. https://doi.org/10.1371/journal.pone.0003391

The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies. Surprisingly, these new data point towards a critical role of autophagy in the patho... Read More about Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Developing novel anthelmintics from plant cysteine proteinases (2008)
Journal Article
Behnke, J. M., Buttle, D. J., Stepek, G., Lowe, A., & Duce, I. (2008). Developing novel anthelmintics from plant cysteine proteinases. Parasites and Vectors, 1(29), https://doi.org/10.1186/1756-3305-1-29

Intestinal helminth infections of livestock and humans are predominantly controlled by treatment with three classes of synthetic drugs, but some livestock nematodes have now developed resistance to all three classes and there are signs that human hoo... Read More about Developing novel anthelmintics from plant cysteine proteinases.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease (2008)
Journal Article
McCarroll, S. A., Huett, A., Kuballa, P., Chilewski, S. D., Landry, A., Goyette, P., …Xavier, R. J. (2008). Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nature Genetics, 40(9), 1107-1112. https://doi.org/10.1038/ng.215

Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn's disease (CD) is associated with SNPs around I... Read More about Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

Temporal and between-site variation in helminth communities of bank voles (Myodes glareolus) from N.E. Poland. 1. Regional fauna and component community levels (2008)
Journal Article
Behnke, J. M., Bajer, A., Harris, P. D., Newington, L., Pidgeon, E., Rowlands, G., …Barnard, C. (2008). Temporal and between-site variation in helminth communities of bank voles (Myodes glareolus) from N.E. Poland. 1. Regional fauna and component community levels. Parasitology, 135(8), https://doi.org/10.1017/S0031182008004393

Helminth infections were studied in bank voles (Myodes glareolus) from 3 woodland sites in N.E. Poland in the late summers of 1999 and 2002, to assess the temporal stability of derived statistics describing the regional helminth fauna and component c... Read More about Temporal and between-site variation in helminth communities of bank voles (Myodes glareolus) from N.E. Poland. 1. Regional fauna and component community levels.

Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function (2008)
Journal Article
Hasan, A. A., Ghaemmaghami, A. M., Fairclough, L., Robins, A., Sewell, H. F., & Shakib, F. (2009). Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function. Immunobiology, 214(1), 2-16. https://doi.org/10.1016/j.imbio.2008.04.006

Dendritic cells are a major source of extracellular thiols needed for T cell activation, a process in which CD40-mediated stimulation plays a pivotal role. The Dermatophagoides pteronyssinus group 1 mite allergen (Der p 1) has previously been shown t... Read More about Allergen-driven suppression of thiol production by human dendritic cells and the effect of thiols on T cell function.

Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC (2008)
Journal Article
Jensen, R. O., Winzer, K., Clarke, S. R., Chan, W. C., & Williams, P. (2008). Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC. Journal of Molecular Biology, 381(2), 300-309. https://doi.org/10.1016/j.jmb.2008.06.018

Virulence in Staphylococcus aureus is regulated via agr-dependent quorum sensing in which an autoinducing peptide (AIP) activates AgrC, a histidine protein kinase. AIPs are usually thiolactones containing seven to nine amino acid residues in which th... Read More about Differential Recognition of Staphylococcus aureus Quorum-Sensing Signals Depends on Both Extracellular Loops 1 and 2 of the Transmembrane Sensor AgrC.

Loss of prokineticin receptor 2 signaling predisposes mice to torpor (2008)
Journal Article
Jethwa, P. H., I'Anson, H., Warner, A., Prosser, H. M., Hastings, M. H., Maywood, E. S., & Ebling, F. J. (2008). Loss of prokineticin receptor 2 signaling predisposes mice to torpor. AJP - Regulatory, Integrative and Comparative Physiology, 294(6), R1968-R1979. https://doi.org/10.1152/ajpregu.00778.2007

The genes encoding prokineticin 2 polypeptide (Prok2) and its cognate receptor (Prokr2/Gpcr73l1) are widely expressed in both the suprachiasmatic nucleus and its hypothalamic targets, and this signaling pathway has been implicated in the circadian re... Read More about Loss of prokineticin receptor 2 signaling predisposes mice to torpor.

Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions or pure randomness? (2008)
Journal Article
Behnke, J. (2008). Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions or pure randomness?. Parasitology, 135(7), https://doi.org/10.1017/S0031182008000334

Experimental data establish that interactions exist between species of intestinal helminths during concurrent infections in rodents, the strongest effects being mediated through the host’s immune responses. Detecting immune-mediated relationships in... Read More about Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions or pure randomness?.

Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers (2008)
Journal Article
Huett, A., & Xavier, R. J. (2008). Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers. Gastroenterology, 134(7), 2164-2168. https://doi.org/10.1053/j.gastro.2008.04.013

Robert Koch was the first to propose a series of definitive tests to determine the agents of infectious disease. Koch's postulates, first published in 1890, were subsequently updated for the molecular era in 1988 by Stanley Falkow1 and continue to fo... Read More about Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers.

Heterobranchia II: The Pulmonata (2008)
Book Chapter
Mordan, P., & Wade, C. (2008). Heterobranchia II: The Pulmonata. In W. Ponder (Ed.), Phylogeny and Evolution of the Mollusca (409-426). University of California Press. https://doi.org/10.1525/california/9780520250925.003.0015

This chapter focuses on the Pulmonata, gastropods belonging to the clade Heterobranchia. It explains that the pulmonates include the large majority of land snails and slugs, as well as many freshwater snails and a few small families of estuarine and... Read More about Heterobranchia II: The Pulmonata.

G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors (2008)
Journal Article
Lane, J. R., Powney, B., Wise, A., Rees, S., & Milligan, G. (2008). G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors. Journal of Pharmacology and Experimental Therapeutics, 325(1), 319-330. https://doi.org/10.1124/jpet.107.134296

The human dopamine D2L receptor couples promiscuously to multiple members of the Gαi/o subfamily. Despite the high homology of the D2L and D3 receptors, the G protein coupling specificity of the human D3 receptor is less clearly characterized. The pr... Read More about G Protein Coupling and Ligand Selectivity of the D2L and D3 Dopamine Receptors.

Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein (2008)
Journal Article
Owsianka, A. M., Tarr, A. W., Keck, Z. Y., Li, T. K., Witteveldt, J., Adair, R., …Patel, A. H. (2008). Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein. Journal of General Virology, 89(3), 653-659. https://doi.org/10.1099/vir.0.83386-0

The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection b... Read More about Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein.

Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae (2008)
Journal Article
Oldfield, N. J., Donovan, E. A., Worrall, K. E., Wooldridge, K. G., Langford, P. R., Rycroft, A. N., & Ala'Aldeen, D. A. (2008). Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Vaccine, 26(16), 1942-1954. https://doi.org/10.1016/j.vaccine.2008.02.022

Actinobacillus pleuropneumoniae is an important respiratory pathogen of swine, for which there is no highly effective vaccine. A phage expression library of the A. pleuropneumoniae genome was constructed and screened to identify potential vaccine com... Read More about Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae.

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis (2008)
Journal Article
Xavier, R. J., Huett, A., & Rioux, J. D. (2008). Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis. Gut, 57(6), 717-720. https://doi.org/10.1136/gut.2007.134254

Crohns disease (CD) is a complex polygenic trait whereby multiple genetic and non-genetic risk factors contribute to disease susceptibility. Association testing is a statistical approach commonly used for identifying genetic risk factors for complex/... Read More about Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.

The genetic diversity of planktic foraminifera and the global distribution of ribosomal RNA genotypes (2008)
Journal Article
Darling, K. F., & Wade, C. M. (2008). The genetic diversity of planktic foraminifera and the global distribution of ribosomal RNA genotypes. Marine Micropaleontology, 67(3-4), 216-238. https://doi.org/10.1016/j.marmicro.2008.01.009

Fossil planktic foraminifers in the ocean sediments play an unparalleled role in our understanding of the oceanographic environment in the past. An in depth knowledge of their diversity, ecology and biogeography in the modern ocean lies central to th... Read More about The genetic diversity of planktic foraminifera and the global distribution of ribosomal RNA genotypes.