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Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium (2004)
Journal Article
Wiles, S., Clare, S., Harker, J., Huett, A., Young, D., Dougan, G., & Frankel, G. (2004). Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium. Cellular Microbiology, 7(3), 459. https://doi.org/10.1111/j.1462-5822.2004.00479.x

In the article by Wiles et al. (2004) the wild-type Citrobacter rodentium (and naladixic acid-resistant derivative) strain used was not David Schauer's DBS100 (Schauer et al., 1993) but ICC168 which is a wild-type strain (formally Citrobacter freundi... Read More about Organ-specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.

Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice (2004)
Journal Article
Li, C. K., Pender, S. L., Pickard, K. M., Chance, V., Holloway, J. A., Huett, A., …MacDonald, T. T. (2004). Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. Journal of Immunology, 173(8), 5171-5179. https://doi.org/10.4049/jimmunol.173.8.5171

Infection of mice with the intestinal bacterial pathogen Citrobacter rodentium results in colonic mucosal hyperplasia and a local Th1 inflammatory response similar to that seen in mouse models of inflammatory bowel disease. Matrix metalloproteinases... Read More about Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice.

Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays (2004)
Journal Article
Harris, J., Mason, D. E., Li, J., Burdick, K. W., Backes, B. J., Chen, T., …Winssinger, N. (2004). Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays. Cell Chemical Biology, 11(10), 1361-1372. https://doi.org/10.1016/j.chembiol.2004.08.008

Enzymatic activity in the fecal droppings from the house dust mite has been postulated to contribute to the elicited allergic response. Screening dust mite extracts through 137,180 tetrapeptide fluorogenic substrates allowed for the characterization... Read More about Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays.

Mucosal vaccination against serogroup B meningococci: Induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin (2004)
Journal Article
Bowe, F., Lavelle, E. C., McNeela, E. A., Hale, C., Clare, S., Arico, B., …Mills, K. H. (2004). Mucosal vaccination against serogroup B meningococci: Induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin. Infection and Immunity, 72(7), 4052-4060. https://doi.org/10.1128/IAI.72.7.4052-4060.2004

Conjugated polysaccharide vaccines protect against serogroup C meningococci. However, this approach cannot be applied to serogroup B, which is still a major cause of meningitis. We evaluated the immunogenicity of three surface-exposed proteins from s... Read More about Mucosal vaccination against serogroup B meningococci: Induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin.

Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium (2004)
Journal Article
Wiles, S., Clare, S., Harker, J., Huett, A., Young, D., Dougan, G., & Frankel, G. (2004). Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium. Cellular Microbiology, 6(10), 963-972. https://doi.org/10.1111/j.1462-5822.2004.00414.x

Citrobacter rodentium belongs to a family of human and animal enteric pathogens that includes the clinically significant enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC). These pathogens use attaching and effacing (A/E)... Read More about Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium.

Molecular evidence links cryptic diversification in polar planktonic protists to Quaternary climate dynamics (2004)
Journal Article
Darling, K. F., Kucera, M., Pudsey, C. J., & Wade, C. M. (2004). Molecular evidence links cryptic diversification in polar planktonic protists to Quaternary climate dynamics. Proceedings of the National Academy of Sciences, 101(20), 7657-7662. https://doi.org/10.1073/pnas.0402401101

It is unknown how pelagic marine protists undergo diversification and speciation. Superficially, the open ocean appears homogeneous, with few clear barriers to gene flow, allowing extensive, even global, dispersal. Yet, despite the apparent lack of o... Read More about Molecular evidence links cryptic diversification in polar planktonic protists to Quaternary climate dynamics.

Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ? (2004)
Journal Article
Howarth, B., Edmunds, M., & Gilbert, F. (2004). Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ?. Evolution, 58(2), 367-375. https://doi.org/10.1111/j.0014-3820.2004.tb01652.x

We tested the prediction that, if hoverflies are Batesian mimics, this may extend to behavioral mimicry such that their numerical abundance at each hour of the day (the daily activity pattern) is related to the numbers of their hymenopteran models. A... Read More about Does the abundance of hoverfly mimics (Syrphidae) depend on the numbers of their hymenopteran models ?.

Variation in the helminth community structure in spiny mice (Acomys dimidiatus) from four montane wadis in the St Katherine region of the Sinai Peninsula in Egypt (2004)
Journal Article
Behnke, J. M., Harris, P. D., Bajer, A., Barnard, C. J., Sherif, N. E., Cliffe, L., …Zalat, S. (2004). Variation in the helminth community structure in spiny mice (Acomys dimidiatus) from four montane wadis in the St Katherine region of the Sinai Peninsula in Egypt. Parasitology, 129(3), https://doi.org/10.1017/S003118200400558X

We compared helminth communities in spiny mice (Acomys dimidiatus) from 4 wadis in the arid montane region of the southern Sinai in Egypt, in a 4-week period in late summer. Total helminth species richness was 14 (8 nematodes, 5 cestodes and 1 acanth... Read More about Variation in the helminth community structure in spiny mice (Acomys dimidiatus) from four montane wadis in the St Katherine region of the Sinai Peninsula in Egypt.

Density-dependent effects on the survival and growth of the rodent stomach worm Protospirura muricola in laboratory mice (2004)
Journal Article
Lowrie, F. M., Behnke, J. M., & Barnard, C. J. (2004). Density-dependent effects on the survival and growth of the rodent stomach worm Protospirura muricola in laboratory mice. Journal of Helminthology, 78(2), 121-128. https://doi.org/10.1079/JOH2003230

The spirurid nematode, Protospirura muricola, is of intrinsic interest as a rodent model of gastric nematode infections. Since worm burdens can be very heavy in nature, density dependent processes may constrain parasite growth. Laboratory mice (BKW)... Read More about Density-dependent effects on the survival and growth of the rodent stomach worm Protospirura muricola in laboratory mice.

Copro-antigen capture ELISA for the detection of Teladorsagia (Ostertagia) circumcincta in sheep: improvement of specificity by heat treatment (2004)
Journal Article
Johnson, D., Behnke, J. M., & Coles, G. C. (2004). Copro-antigen capture ELISA for the detection of Teladorsagia (Ostertagia) circumcincta in sheep: improvement of specificity by heat treatment. Parasitology, 129(1), 115-126. https://doi.org/10.1017/S0031182004005256

A copro-antigen capture ELISA for the detection of Teladorsagia circumcincta infection in sheep was developed and evaluated. Experiments with faeces from worm-free sheep, that had been spiked with known concentrations of excretory-secretory (E–S) ant... Read More about Copro-antigen capture ELISA for the detection of Teladorsagia (Ostertagia) circumcincta in sheep: improvement of specificity by heat treatment.

Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors (2004)
Journal Article
Ahmed, B., Chakravarthy, S., Eggers, R., Hermens, W., Zhang, J., Niclou, S., …Verhaagen, J. (2004). Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors. BMC Neuroscience, 5(1), Article 4. https://doi.org/10.1186/1471-2202-5-4

BACKGROUND: Inactivating genes in vivo is an important technique for establishing their function in the adult nervous system. Unfortunately, conventional knockout mice may suffer from several limitations including embryonic or perinatal lethality and... Read More about Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors.