Skip to main content

Research Repository

Advanced Search

All Outputs (70)

The danger theory and its application to Artificial Immune Systems (2002)
Conference Proceeding
Aickelin, U., & Cayzer, S. (2002). The danger theory and its application to Artificial Immune Systems. In J. Timmis, & P. J. Bentley (Eds.), ICARIS 2002: 1st International Conference on Artificial Immune Systems, 141-148

Over the last decade, a new idea challenging the classical self-non-self viewpoint has become popular amongst immunologists. It is called the Danger Theory. In this conceptual paper, we look at this theory from the perspective of Artificial Immune Sy... Read More about The danger theory and its application to Artificial Immune Systems.

Hypothalamic Interactions Between Neuropeptide Y, Agouti-Related Protein, Cocaine- and Amphetamine-Regulated Transcript and Alpha-Melanocyte-Stimulating Hormone In Vitro in Male Rats (2002)
Journal Article
Dhillo, W. S., Small, C. J., Stanley, S. A., Jethwa, P. H., Seal, L. J., Murphy, K. G., …Bloom, S. R. (2002). Hypothalamic Interactions Between Neuropeptide Y, Agouti-Related Protein, Cocaine- and Amphetamine-Regulated Transcript and Alpha-Melanocyte-Stimulating Hormone In Vitro in Male Rats. Journal of Neuroendocrinology, 14(9), 725-730. https://doi.org/10.1046/j.1365-2826.2002.00832.x

A number of neuropeptides implicated in the hypothalamic regulation of appetite are synthesized in the arcuate nucleus (Arc). Neuropeptide Y (NPY) and agouti-related protein (Agrp) are orexigenic. The pro-opiomelanocortin (POMC) product alpha-melanoc... Read More about Hypothalamic Interactions Between Neuropeptide Y, Agouti-Related Protein, Cocaine- and Amphetamine-Regulated Transcript and Alpha-Melanocyte-Stimulating Hormone In Vitro in Male Rats.

Poverty, caring and older age (2002)
Journal Article
Argyle, E. (2002). Poverty, caring and older age

Due to the high incidence of disability amongst their contemporaries, older people are likely to be involved in informal caring relationships. Due to the limited nature of post-retirement incomes, such carers are also likely to be relatively poor. In... Read More about Poverty, caring and older age.

Inferring the phylogeny of disjunct populations of the azure-winged magpie Cyanopica cyanus from mitochondrial control region sequences (2002)
Journal Article
Koon, W. F., Wade, C. M., & Parkin, D. T. (2002). Inferring the phylogeny of disjunct populations of the azure-winged magpie Cyanopica cyanus from mitochondrial control region sequences. Proceedings of the Royal Society B: Biological Sciences, 269(1501), 1671-1679. https://doi.org/10.1098/rspb.2002.2057

The azure-winged magpie (AWM), Cyanopica cyanus, is found in Asia and Iberia. This remarkable disjunct distribution has been variously explained by either the sixteenth-century introduction of birds into Iberia from the Far East, or by the loss of in... Read More about Inferring the phylogeny of disjunct populations of the azure-winged magpie Cyanopica cyanus from mitochondrial control region sequences.

Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe (2002)
Journal Article
Atkinson, G. E., Cowan, A., McInnes, C., Zheleva, D. I., Fischer, P. M., & Chan, W. C. (2002). Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe. Bioorganic and Medicinal Chemistry Letters, 12(18), 2501-2505. https://doi.org/10.1016/S0960-894X%2802%2900508-5

A focused series of octapeptides based on the lead compound H-His-Ala-Lys-Arg-Arg-Leu-Ile-Phe-NH2 1, in which the C-terminal phenylalanine residue was replaced by α and/or β-modified variants, was synthesized using solid-phase chemistry. Both the L-t... Read More about Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: Structural variants of the C-Terminal Phe.

Vaccines against human enteric bacterial pathogens (2002)
Journal Article
Dougan, G., Huett, A., & Clare, S. (2002). Vaccines against human enteric bacterial pathogens. British Medical Bulletin, 62(1), 113-123. https://doi.org/10.1093/bmb/62.1.113

The development of vaccines against enteric bacterial pathogens presents a challenge because of the large number of pathogens capable of causing disease and the requirement to induce immunity that is effective in the gut. A new generation of enteric... Read More about Vaccines against human enteric bacterial pathogens.

Host/pathogen interactions at mucosal surfaces: Immune consequences (2002)
Journal Article
Clare, S., Huett, A., & Dougan, G. (2002). Host/pathogen interactions at mucosal surfaces: Immune consequences. Research in Microbiology, 153(7), 455-459. https://doi.org/10.1016/S0923-2508%2802%2901345-1

The mucosal immune system has evolved to protect the host against the establishment of infections at or through the mucosal surfaces of the body. Protective immunity must be activated to specific pathogenic agents or their products but inappropriate... Read More about Host/pathogen interactions at mucosal surfaces: Immune consequences.

The design and characterisation of an optical VLSI processor for real time centroid detection (2002)
Journal Article
Pui, B. H., Hayes-Gill, B., Clark, M., Somekh, M., See, C., Piéri, J. F., …Ng, A. (2002). The design and characterisation of an optical VLSI processor for real time centroid detection. Analog Integrated Circuits and Signal Processing, 32(1), 67-75. https://doi.org/10.1023/A%3A1016075825331

The integration of photo-detectors onto a standard CMOS integrated circuit is presented. This device provides the optical front end for a real time centroid detection system to be used as part of a larger system for implementing a Shack-Hartmann wave... Read More about The design and characterisation of an optical VLSI processor for real time centroid detection.

Missverständnisse, Rollenspiele, Double Binds: Kommunikation und Bewusstsein im Werk Birgit Vanderbekes (2002)
Journal Article
Uecker, M. (2002). Missverständnisse, Rollenspiele, Double Binds: Kommunikation und Bewusstsein im Werk Birgit Vanderbekes. German Life and Letters, 5(3), https://doi.org/10.1111/1468-0483.00232

Abweichend von der dominierenden Strategie der Literaturkritik, die das Werk Birgit Vanderbekes in erster Linie auf seine soziologische Repräsentativität für Entwicklungen der deutschen Gesellschaft seit den fünfziger Jahren untersucht hat, konzentri... Read More about Missverständnisse, Rollenspiele, Double Binds: Kommunikation und Bewusstsein im Werk Birgit Vanderbekes.

New treatments for atopic dermatitis (2002)
Journal Article
Williams, H. (2002). New treatments for atopic dermatitis. British medical journal, 324,

Atopic dermatitis now affects 15% to 20% of chil­dren in developed countries, and prevalence in cities in developing countries undergoingrapid demographic changes is quickly following suit. [1] Most cases of atopic dermatitis in a given communityare... Read More about New treatments for atopic dermatitis.

The Design of a Real Time VLSI Optical Centroid Processor (2002)
Conference Proceeding
Pui, B. H., Hayes-Gill, B., Clark, M., Somekh, M., See, C., Morgan, S., & Ng, A. (2002). The Design of a Real Time VLSI Optical Centroid Processor. In IEEE Sensors 2002 : first IEEE International Conference on Sensors. https://doi.org/10.1109/ICSENS.2002.1036977

A real time VLSI optical centroid processor has been developed as part of a larger Shack-Hartmann wavefront sensor system for applications in adaptive optics. The implementation of the optical centroid detection system was demonstrated successfully u... Read More about The Design of a Real Time VLSI Optical Centroid Processor.

A molecular phylogeny of nuclear and mitochondrial sequences in Hymenolepis nana (Cestoda) supports the existence of a cryptic species (2002)
Journal Article
MacNish, M., Morgan-Ryan, U., Monis, P., Behnke, J., & Thompson, R. (2002). A molecular phylogeny of nuclear and mitochondrial sequences in Hymenolepis nana (Cestoda) supports the existence of a cryptic species. Parasitology, 125(6), https://doi.org/10.1017/S0031182002002366

Since isolates of Hymenolepis nana infecting humans and rodents are morphologically indistinguishable, the only way they can be reliably identified is by comparing the parasite in each host using molecular tools. In the current study, isolates of H.... Read More about A molecular phylogeny of nuclear and mitochondrial sequences in Hymenolepis nana (Cestoda) supports the existence of a cryptic species.

Local variation in endoparasite intensities of bank voles (Clethrionomys glareolus )from ecologically similar sites: morphometric and endocrine correlates (2002)
Journal Article
Barnard, C., Behnke, J., Bajer, A., Bray, D., Race, T., Frake, K., …Sinski, E. (2002). Local variation in endoparasite intensities of bank voles (Clethrionomys glareolus )from ecologically similar sites: morphometric and endocrine correlates. Journal of Helminthology, 76(2), https://doi.org/10.1079/JOH2001109

Much interest has centred recently on the role of adaptive trade-offs between the immune system and other components of life history in determining resistance and parasite intensities among hosts. Steroid hormones, particularly glucocorticoids and se... Read More about Local variation in endoparasite intensities of bank voles (Clethrionomys glareolus )from ecologically similar sites: morphometric and endocrine correlates.

Homochiral 4-azalysine building blocks: Syntheses and applications in solid-phase chemistry (2002)
Journal Article
Chhabra, S. R., Mahajan, A., & Chan, W. C. (2002). Homochiral 4-azalysine building blocks: Syntheses and applications in solid-phase chemistry. Journal of Organic Chemistry, 67(12), 4017-4029. https://doi.org/10.1021/jo010456e

Anomalous amino acids not only play central roles as mimics of natural amino acids but also offer opportunities as unique building blocks for combinatorial chemistry. This paper describes the chiral syntheses and solid-phase applications of a versati... Read More about Homochiral 4-azalysine building blocks: Syntheses and applications in solid-phase chemistry.

Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells (2002)
Journal Article
Ghaemmaghami, A. M., & Shakib, F. (2002). Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells. Clinical and Experimental Allergy, 32(5), 728-732. https://doi.org/10.1046/j.1365-2222.2002.01374.x

Background: We have previously demonstrated that the proteolytic activity of Der p 1 selectively cleaves human CD25, the 55 kDa α subunit of the IL-2 receptor. As a result of cleavage of surface CD25, peripheral blood T cells produce less IFN-γ and m... Read More about Human T cells that have been conditioned by the proteolytic activity of the major dust mite allergen Der p 1 trigger enhanced immunoglobulin E synthesis by B cells.

Characterization of the Campylobacter jejuni Heptosyltransferase II Gene, waaF, Provides Genetic Evidence that Extracellular Polysaccharide Is Lipid A Core Independent (2002)
Journal Article
Oldfield, N. J., Moran, A. P., Millar, L. A., Prendergast, M. M., & Ketley, J. M. (2002). Characterization of the Campylobacter jejuni Heptosyltransferase II Gene, waaF, Provides Genetic Evidence that Extracellular Polysaccharide Is Lipid A Core Independent. Journal of Bacteriology, 184(8), 2100-2107. https://doi.org/10.1128/JB.184.8.2100-2107.2002

Campylobacter jejuni produces both lipooligosaccharide (LOS) and a higher-molecular-weight polysaccharide that is believed to form a capsule. The role of these surface polysaccharides in C jejuni-mediated enteric disease is unclear; however, epitopes... Read More about Characterization of the Campylobacter jejuni Heptosyltransferase II Gene, waaF, Provides Genetic Evidence that Extracellular Polysaccharide Is Lipid A Core Independent.

The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance (2002)
Journal Article
Rees, L., Wood, N., Gillespie, K., Lai, K., Gaston, K., & Mathieson, P. (2002). The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance. Cellular and Molecular Life Sciences, 59(3), 560-569. doi:10.1007/s00018-002-8448-0

Genotypic variation in the human interleukin-10 (IL-10) promoter may account for marked inter-individual variation in IL-10 production and may influence susceptibility to autoimmune diseases. The G/A polymorphism at position -1082 has been linked to... Read More about The interleukin-10 – 1082 G/A polymorphism: allele frequency in different populations and functional significance.