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All Outputs (187)

Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo (2024)
Working Paper
Semizoglou, E., Lo Re, L., Middleton, S. J., Perez-Sanchez, J., Tufarelli, T., Bennett, D. L., & Chisholm, K. I. Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo

C-low threshold mechanoreceptors (C-LTMRs) in animals (termed C-tactile (CT) fibres in humans) are a subgroup of C-fibre primary afferents, which innervate hairy skin and respond to low threshold punctate indentations and brush stimuli. These afferen... Read More about Characterising the stimulus-response function of mouse C-Low threshold mechanoreceptors to mechanical stimuliin vivo.

Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study (2024)
Working Paper
Suzuki, T., Kaneda, Y., Kotera, Y., Tanimoto, T., Ozaki, A., Bhandari, D., …Tabuchi, T. Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study

Background: Non-consensual sex including rape and sexual assault has been a global concern and may have been influenced by the COVID-19 pandemic, however the information on this topic is limited. Therefore, our objective was to survey the incidence r... Read More about Non-Consensual Sex among Japanese Women in the COVID-19 Pandemic: A Large-Scale Nationwide Survey-Based Study.

Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction (2024)
Working Paper
Thangamuthu, M., Burwell, T., Aliev, G., Ghaderzadeh, S., Kohlrausch, E., Chen, Y., …Khlobystov, A. Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction

Minimizing our reliance on bulk precious metals is to increase the fraction of surface atoms and improve the metal-support interface. In this work, we employ a solvent/ligand/counterion-free method to deposit copper in the atomic form directly onto a... Read More about Direct Deposition of Copper Atoms onto Graphitic Step Edges Lowers Overpotential and Improves Selectivity of Electrocatalytic CO2 Reduction.

Assessing spontaneous sensory neuron activity usingin vivocalcium imaging (2024)
Working Paper
Ingram, S. L., Chisholm, K. I., Wang, F., De Koninck, Y., Denk, F., & Goodwin, G. L. Assessing spontaneous sensory neuron activity usingin vivocalcium imaging

Heightened spontaneous activity in sensory neurons is often reported in individuals living with chronic pain. It is possible to study this activity in rodents using electrophysiology, but these experiments require great skill and can be prone to bias... Read More about Assessing spontaneous sensory neuron activity usingin vivocalcium imaging.

A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom (2024)
Working Paper
De Dios Perez, B., Booth, V., das Nair, R., Evangelou, N., Hassard, J., Ford, H. L., …Radford, K. A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom

Background To explore how a vocational rehabilitation (VR) intervention can be integrated within existing healthcare services for people with multiple sclerosis (MS) in the United Kingdom (UK) National Health Service (NHS). Methods Data from 37... Read More about A qualitative study exploring how vocational rehabilitation for people with multiple sclerosis can be integrated within existing healthcare services in the United Kingdom.

Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet (2024)
Working Paper
de la Fuente, C., Grondin, A., Sine, B., Debieu, M., Belin, C., Hajjarpoor, A., …Laplaze, L. Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

Seedling root traits impact plant establishment under challenging environments. Pearl millet is one of the most heat and drought tolerant cereal crops that provides a vital food source across the sub-Saharan Sahel region. Pearl millet’s early root sy... Read More about Author Response: Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet.

Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells (2024)
Working Paper
Al-Hayali, M. Z., Nge, C., Lim, K. H., Collins, H. M., Kam, T. S., & Bradshaw, T. D. Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells

Natural products contribute substantially to anticancer therapy; the plant kingdom provides an important source of molecules. Conofolidine is a novel Aspidosperma-Aspidosperma bisindole alkaloid isolated from the Malayan plant Tabernaemontana corymbo... Read More about Conofolidine, a Natural Plant Alkaloid Causes Apoptosis and Senescence in Cancer Cells.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2023)
Working Paper
Abhishek, A., Grainge, M. J., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. D. Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation

Background Sulfasalazine induced cytopenia, nephrotoxicity, and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend three monthly monitoring blood-tests indefinitely while others recommend stopping monitoring after one ye... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial (2023)
Working Paper
Greaves, S., Harvey, C., & Kotera, Y. (2023). Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

The study aimed to investigate the effect of climate change exposure on affect and pro-environmental behavioural intentions in a randomised controlled trial. An online survey was completed by 100 adult participants and included measures of affect and... Read More about Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial.

A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2 (2023)
Working Paper
Mitchell-White, J. I., Briggs, D. A., Mistry, S. J., Mbiwan, H. A., Kellam, B., Holliday, N. D., …Kerr, I. D. A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2

The human ATP-binding cassette (ABC) transporter, ABCG2 is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider p... Read More about A time-resolved Förster resonance energy transfer assay to investigate inhibitor binding to ABCG2.

Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases (2023)
Working Paper
Huang, J., Shek, N., Choy, A., Lang, C., Miller, B., Tal-Singer, R., …Brown, M. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases

Aging is a major driving force for many diseases but the relationship between age, aging processes and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related... Read More about Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education (2023)
Working Paper
Church, H. R., Brown, M. E., Govender, L., & Clark, D. Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education

Background: The number of healthcare professionals leaving clinical practice and transitioning to alternative careers in health professions education is increasing. Among these non-practicing healthcare professionals, concerns have been reported rega... Read More about Beyond the Bedside: Protocol for a scoping review exploring the experiences of non-practicing healthcare professionals within health professions education.

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data (2023)
Working Paper
Zuffa, S., Schmid, R., Bauermeister, A., Gomes, P. W. P., Caraballo-Rodriguez, A. M., Abiead, Y. E., …Dorrestein, P. C. A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST, a taxonomically-informed mass spectrometry (MS) search tool, tackles limited microbial metabolite annotation in untargeted metabolomics experiments. Leveraging a curated database of >60,000 microbial monocultures, users can search known... Read More about A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data.

Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror (2023)
Working Paper
Dowthwaite, L., Reyez Cruz, G., Pena, A. R., Pepper, C., Jäger, N., Barnard, P., …Benford, S. Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror

The home is becoming a key location for healthcare delivery, including the use of technology driven by autonomous systems (AS) to monitor and support healthcare plans. Using the example of a smart mirror, this paper describes the outcomes of focus gr... Read More about Examining the Use of Autonomous Systems for Home Health Support using a Smart Mirror.

PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry (2023)
Working Paper
Ali, H., Ahmed, I., Robertson, K., & Lanterna, A. PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry

Perylene diimides (PDI) have an extraordinary ability to activate both energy and electron transfer process upon light excitation, however, their extremely low solubility has hindered their wide use as photocatalysts. Here, we show a series of suppor... Read More about PDI-functionalised glass beads: efficient, metal-free heterogeneous photocatalysts suitable for flow photochemistry.

UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI) (2023)
Working Paper
McClaughlin, E., Elliott, S., Jewitt, S., Smallman-Raynor, M., Dunham, S., Parnell, T., …Tarlinton, R. UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI)

The scale of the current outbreak of highly pathogenic avian influenza (HPAI) due to the A/H5N1 virus in the United Kingdom is unprecedented. In addition to its economic impact on the commercial poultry sector, the disease has devastated wild bird co... Read More about UK Flockdown: Exploring the knowledge, attitudes and practices of backyard poultry keepers surrounding Highly Pathogenic Avian Influenza (HPAI).

Generative AI: Implications and Applications for Education (2023)
Working Paper
Olga, A., Saini, A., Zapata, G., Searsmith, D., Cope, B., Kalantzis, M., …Polyxeni Kastania, N. Generative AI: Implications and Applications for Education

The launch of ChatGPT in November 2022 precipitated a panic among some educators while prompting qualified enthusiasm from others. Under the umbrella term Generative AI, ChatGPT is an example of a range of technologies for the delivery of computer-ge... Read More about Generative AI: Implications and Applications for Education.

The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study (2023)
Working Paper
Swiderski, M., Vinogradova, Y., Knaggs, R., Harman, K., Harwood, R., Prasad, V., …Gran, S. (0000). The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study

Introduction Bullous pemphigoid (BP) is a serious skin disease that results in large painful blisters developing over the body and occurs most commonly in older people (over 70 years). Despite several comorbidities such as stroke and a threefold inc... Read More about The association between prescription drugs and vaccines commonly prescribed to older people and bullous pemphigoid: a UK population-based study.