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All Outputs (18)

Dementia and hearing-aid use: a two-way street (2022)
Journal Article
Naylor, G., Dillard, L., Orrell, M., Stephan, B. C. M., Zobay, O., & Saunders, G. H. (2022). Dementia and hearing-aid use: a two-way street. Age and Ageing, 51(12), Article afac266. https://doi.org/10.1093/ageing/afac266

Objectives Hearing-aid use may reduce risk of dementia, but cognitive impairment makes use more challenging. An observed association between reduced hearing-aid use and incident dementia could reflect either or both of these causal paths. The object... Read More about Dementia and hearing-aid use: a two-way street.

Determinants for COVID-19 vaccine hesitancy in the general population: a systematic review of reviews (2022)
Journal Article
Kafadar, A. H., Tekeli, G. G., Jones, K. A., Stephan, B., & Dening, T. (2022). Determinants for COVID-19 vaccine hesitancy in the general population: a systematic review of reviews. Journal of Public Health, https://doi.org/10.1007/s10389-022-01753-9

Aim: Although multiple COVID-19 vaccines are approved for global use, vaccine hesitancy poses a substantial risk for global health. Therefore, the aim of this umbrella review is to identify those factors that influence COVID-19 vaccination hesitancy... Read More about Determinants for COVID-19 vaccine hesitancy in the general population: a systematic review of reviews.

Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999–2002 (2021)
Journal Article
Goddard, T., Tsintzas, K., Stephan, B. C., Prado, C. M., Mazidi, M., & Siervo, M. (2021). Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999–2002. International Journal of Obesity, 46, 437–440. https://doi.org/10.1038/s41366-021-00995-z

Sarcopenic obesity (SO) is characterised by the concurrent presence of sarcopenia and excess adiposity. Telomere shortening has been associated with sarcopenia and obesity alone but the association between SO and telomere length (TL) has not been inv... Read More about Sarcopenic obesity is associated with telomere shortening: findings from the NHANES 1999–2002.

Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People: Findings From the DECIDE Study (2021)
Journal Article
Richardson, S., Murray, J., Davis, D., Stephan, B. C., Robinson, L., Brayne, C., …Allan, L. (2022). Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People: Findings From the DECIDE Study. Journals of Gerontology, Series A, 77(3), 531–535. https://doi.org/10.1093/gerona/glab081

Background: Delirium is common, distressing and associated with poor outcomes. Despite this, delirium remains poorly recognised, resulting in worse outcomes. There is an urgent need for methods to objectively assess for delirium. Physical functio... Read More about Delirium and Delirium Severity Predict the Trajectory of the Hierarchical Assessment of Balance and Mobility in Hospitalized Older People: Findings From the DECIDE Study.

27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium (2020)
Journal Article
Wolters, F. J., Chibnik, L. B., Waziry, R., Anderson, R., Berr, C., Beiser, A., …Hofman, A. (2020). 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium. Neurology, 95(5), https://doi.org/10.1212/wnl.0000000000010022

Objective To determine changes in the incidence of dementia between 1988 and 2015. Methods This analysis was performed in aggregated data from individuals >65 years of age in 7 population-based cohort studies in the United States and Europe from t... Read More about 27-year time trends in dementia incidence in Europe and the US: the Alzheimer Cohorts Consortium.

Assessing the Predictive Validity of Simple Dementia Risk Models in Harmonized Stroke Cohorts (2020)
Journal Article
Tang, E. Y., Price, C. I., Robinson, L., Exley, C., Desmond, D. W., Köhler, S., …Stephan, B. C. (2020). Assessing the Predictive Validity of Simple Dementia Risk Models in Harmonized Stroke Cohorts. Stroke, 51(7), 2095-2102. https://doi.org/10.1161/strokeaha.120.027473

BACKGROUND AND PURPOSE: Stroke is associated with an increased risk of dementia. To assist in the early identification of individuals at high risk of future dementia, numerous prediction models have been developed for use in the general population. H... Read More about Assessing the Predictive Validity of Simple Dementia Risk Models in Harmonized Stroke Cohorts.

Changing lifestyle for dementia risk reduction: Inductive content analysis of a national UK survey (2020)
Journal Article
Bosco, A., Jones, K. A., Di Lorito, C., Stephan, B. C., Orrell, M., & Oliveira, D. (2020). Changing lifestyle for dementia risk reduction: Inductive content analysis of a national UK survey. PLoS ONE, 15(5), https://doi.org/10.1371/journal.pone.0233039

Objective: To explore what motivates individuals to change their behaviour to reduce their risk of dementia. Methods: We conducted secondary qualitative analysis of a UK-based online survey on motivation to change lifestyle and health behaviour for... Read More about Changing lifestyle for dementia risk reduction: Inductive content analysis of a national UK survey.

Undiagnosed dementia in primary care: a record linkage study (2020)
Journal Article
Aldus, C. F., Arthur, A., Dennington-Price, A., Millac, P., Richmond, P., Dening, T., …Savva, G. M. (2020). Undiagnosed dementia in primary care: a record linkage study. Health Services and Delivery Research, 8(20), 1-108. https://doi.org/10.3310/hsdr08200

Background The number of people living with dementia is greater than the number with a diagnosis of dementia recorded in primary care. This suggests that a significant number are living with dementia that is undiagnosed. Little is known about this... Read More about Undiagnosed dementia in primary care: a record linkage study.

Prediction of dementia risk in low-income and middle-income countries (the 10/66 Study): an independent external validation of existing models (2020)
Journal Article
Stephan, B. C., Pakpahan, E., Siervo, M., Licher, S., Muniz-Terrera, G., Mohan, D., …Prina, M. (2020). Prediction of dementia risk in low-income and middle-income countries (the 10/66 Study): an independent external validation of existing models. Lancet Global Health, 8(4), Article e524 - e535. https://doi.org/10.1016/s2214-109x%2820%2930062-0

Background To date, dementia prediction models have been exclusively developed and tested in high-income countries (HICs). However, most people with dementia live in low-income and middle-income countries (LMICs), where dementia risk prediction rese... Read More about Prediction of dementia risk in low-income and middle-income countries (the 10/66 Study): an independent external validation of existing models.

Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis (2019)
Journal Article
Rockwood, K., Peters, R., Yasar, S., Anderson, C. S., Andrews, S., Antikainen, R., …Anstey, K. J. (2020). Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis. Neurology, 94(3), e267-e281. https://doi.org/10.1212/wnl.0000000000008732

Objective High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular an... Read More about Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.

Mediterranean diet adherence and cognitive function in older UK adults: The European Prospective Investigation into Cancer and Nutrition-Norfolk (EPIC-Norfolk) Study (2019)
Journal Article
Shannon, O. M., Stephan, B. C. M., Granic, A., Lentjes, M., Hayat, S., Mulligan, A., …Siervo, M. (2019). Mediterranean diet adherence and cognitive function in older UK adults: The European Prospective Investigation into Cancer and Nutrition-Norfolk (EPIC-Norfolk) Study. American Journal of Clinical Nutrition, 110(4), 938-948. https://doi.org/10.1093/ajcn/nqz114

© 2019 American Society for Nutrition. Background: In Mediterranean countries, adherence to a traditional Mediterranean dietary pattern (MedDiet) is associated with better cognitive function and reduced dementia risk. It is unclear if similar benefit... Read More about Mediterranean diet adherence and cognitive function in older UK adults: The European Prospective Investigation into Cancer and Nutrition-Norfolk (EPIC-Norfolk) Study.

Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies (2018)
Journal Article
Ikram, M. A., Licher, S., Ikram, M. K., Leening, M. J., Steyerberg, E. W., Yilmaz, P., …Alzheimer’s Disease Neuroimaging Initiative. (2019). Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies. American Journal of Psychiatry, 176(7), 543-551. https://doi.org/10.1176/appi.ajp.2018.18050566

© 2019 American Psychiatric Association. All rights reserved. Objective: Identification of individuals at high risk of dementia is essential for development of prevention strategies, but reliable tools are lacking for risk stratification in the popul... Read More about Development and Validation of a Dementia Risk Prediction Model in the General Population: An Analysis of Three Longitudinal Studies.

Sarcopenic obesity and overall mortality: Results from the application of novel models of body composition phenotypes to the National Health and Nutrition Examination Survey 1999–2004 (2018)
Journal Article
Van Aller, C., Lara, J., C.M. Stephan, B., Donini, L. M., Heymsfield, S., Katzmarzyk, P. T., …Siervo, M. (2019). Sarcopenic obesity and overall mortality: Results from the application of novel models of body composition phenotypes to the National Health and Nutrition Examination Survey 1999–2004. Clinical Nutrition, 38(1), 264-270. https://doi.org/10.1016/j.clnu.2018.01.022

Background/Objectives There is no consensus on the definition of sarcopenic obesity (SO), resulting in inconsistent associations of SO with mortality risk. We aim to evaluate association of dual energy x-ray absorptiometry (DXA) SO models with mor... Read More about Sarcopenic obesity and overall mortality: Results from the application of novel models of body composition phenotypes to the National Health and Nutrition Examination Survey 1999–2004.

Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study (2017)
Journal Article
Lipnicki, D. M., Crawford, J. D., Dutta, R., Thalamuthu, A., Kochan, N. A., Andrews, G., …Sachdev, P. S. (2017). Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. PLoS Medicine, 14(3), Article e1002261. https://doi.org/10.1371/journal.pmed.1002261

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies (2017)
Journal Article
Davis, D. H. J., Muniz-Terrera, G., Keage, H. A. D., Stephan, B. C. M., Fleming, J., Ince, P. G., …Brayne, C. (2017). Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies. JAMA Psychiatry, 74(3), 244-251. https://doi.org/10.1001/jamapsychiatry.2016.3423

© 2017 American Medical Association. Importance: Delirium is associated with accelerated cognitive decline. The pathologic substrates of this association are not yet known, that is, whether they are the same as those associated with dementia, are ind... Read More about Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies.

A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II (2016)
Journal Article
Matthews, F. E., Stephan, B. C. M., Robinson, L., Jagger, C., Barnes, L. E., Arthur, A., & Brayne, C. (2016). A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Nature Communications, 7(1), Article 11398. https://doi.org/10.1038/ncomms11398

Dramatic global increases in future numbers of people with dementia have been predicted. No multicentre population-based study powered to detect changes over time has reported dementia incidence. MRC Cognitive Function and Ageing Study (CFAS) underto... Read More about A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II.

Usefulness of data from magnetic resonance imaging to improve prediction of dementia: population based cohort study (2015)
Journal Article
Stephan, B. C. M., Tzourio, C., Auriacombe, S., Amieva, H., Dufouil, C., Alperovitch, A., & Kurth, T. (2015). Usefulness of data from magnetic resonance imaging to improve prediction of dementia: population based cohort study. BMJ, 350, https://doi.org/10.1136/bmj.h2863

© BMJ Publishing Group Ltd 2015. OBJECTIVE: To determine whether the addition of data derived from magnetic resonance imaging (MRI) of the brain to a model incorporating conventional risk variables improves prediction of dementia over 10 years of fol... Read More about Usefulness of data from magnetic resonance imaging to improve prediction of dementia: population based cohort study.