All Outputs (67)

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink (2018)
Journal Article
Pearce, F. A., Lanyon, P. C., Watts, R. A., Grainge, M. J., Abhishek, A., & Hubbard, R. B. (2018). Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink. Rheumatology, 57(10), 1873. https://doi.org/10.1093/rheumatology/key249

This is a correction to: Rheumatology, Volume 57, Issue 6, June 2018, Pages 1002–1010, https://doi.org/10.1093/rheumatology/kex512

Are working practices of lung cancer nurse specialists associated with variation in peoples’ receipt of anticancer therapy? (2018)
Journal Article
Stewart, I., Khakwani, A., Hubbard, R. B., Beckett, P., Borthwick, D., Tod, A., …Tata, L. J. (2018). Are working practices of lung cancer nurse specialists associated with variation in peoples’ receipt of anticancer therapy?. Lung Cancer, 123, 160-165. https://doi.org/10.1016/j.lungcan.2018.07.022

Objectives Treatment choices for people with lung cancer may be influenced by contact and engagement with lung cancer nurse specialists (LCNSs). We investigated how service factors, LCNS workload, and LCNS working practices may influence the recei... Read More about Are working practices of lung cancer nurse specialists associated with variation in peoples’ receipt of anticancer therapy?.

Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink (2018)
Journal Article
Pearce, F. A., Lanyon, P. C., Watts, R. A., Grainge, M. J., Abhishek, A., & Hubbard, R. B. (2018). Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink. Rheumatology, 57(6), 1002-1010. https://doi.org/10.1093/rheumatology/kex512

Objectives: We aimed to provide insights into the aetiology of granulomatosis with polyangiitis (GPA), by conducting a large case–control study using a general population-based, prospectively collected database of healthcare records. Methods: We... Read More about Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink.

Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study (2017)
Journal Article
Navaratnam, V., Root, A. A., Douglas, I., Smeeth, L., Hubbard, R. B., & Quint, J. K. (2018). Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study. Annals of the American Thoracic Society, 15(3), https://doi.org/10.1513/AnnalsATS.201706-488OC

Rationale: Studies suggest that people with bronchiectasis are at increased risk of cardiovascular co-morbidities. Objectives: We aimed to quantify the relative risk of incident cardiovascular events following a respiratory tract infection amongs... Read More about Cardiovascular outcomes following a respiratory tract infection among adults with non-CF bronchiectasis: a general population based study.

An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study (2017)
Journal Article
Maher, T. M., Oballa, E., Simpson, J. K., Porte, J., Habgood, A., Fahy, W. A., …Jenkins, R. G. (in press). An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study. Lancet Respiratory Medicine, 5(12), https://doi.org/10.1016/S2213-2600%2817%2930430-7

Background: Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal condition with a variable disease trajectory. The aim of this study was to evaluate potential biomarkers that predict outcome for people with IPF. Method: The PROFILE study is a... Read More about An epithelial biomarker signature for idiopathic pulmonary fibrosis: an analysis from the multicentre PROFILE cohort study.

ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis (2017)
Journal Article
Philp, C. J., Siebeke, I., Clements, D., Miller, S., Habgood, A., John, A. E., …Johnson, S. R. (2018). ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis. American Journal of Respiratory Cell and Molecular Biology, 58(5), 594–603. https://doi.org/10.1165/rcmb.2016-0379OC

Idiopathic pulmonary fibrosis (IPF) is characterised by accumulation of extra cellular matrix (ECM) proteins and fibroblast proliferation. ECM cross-linking enzymes have been implicated in fibrotic diseases and we hypothesised that the ECM in IPF is... Read More about ECM crosslinking enhances fibroblast growth and protects against matrix proteolysis in lung fibrosis.

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study (2017)
Journal Article
Allen, R. J., Porte, J., Braybrooke, R., Flores, C., Fingerlin, T. E., Oldham, J. M., …Jenkins, R. G. (2017). Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study. Lancet Respiratory Medicine, 5(11), https://doi.org/10.1016/S2213-2600%2817%2930387-9

Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified a significant genetic risk associated with the development of IPF; however,... Read More about Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.

Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study (2017)
Journal Article
Pearce, F. A., Hubbard, R., Grainge, M. J., Watts, R. A., Abhishek, A., & Lanyon, P. C. (in press). Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study. QJM: An International Journal of Medicine, https://doi.org/10.1093/qjmed/hcx194

Background: People with granulomatosis with polyangiitis (GPA) commonly describe long delays before diagnosis. Aim: To study the natural history of GPA prior to diagnosis using primary care data, and determine whether clinical features could be iden... Read More about Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study.

Apples and pears? A comparison of two sources of national lung cancer audit data in England (2017)
Journal Article
Khakwani, A., Jack, R. H., Vernon, S., Dickinson, R., Wood, N., Harden, S., …Hubbard, R. B. (2017). Apples and pears? A comparison of two sources of national lung cancer audit data in England. ERJ Open Research, 3(3), 00003-2017. https://doi.org/10.1183/23120541.00003-2017

In 2014, the method of data collection from NHS trusts in England for the National Lung Cancer Audit (NLCA) was changed from a bespoke dataset called LUCADA (Lung Cancer Data). Under the new contract, data are submitted via the Cancer Outcome and Ser... Read More about Apples and pears? A comparison of two sources of national lung cancer audit data in England.

The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink (2016)
Journal Article
Pearce, F. A., Grainge, M. J., Lanyon, P. C., Watts, R. A., & Hubbard, R. B. (in press). The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink. Rheumatology, https://doi.org/10.1093/rheumatology/kew413

Objectives: To estimate the incidence, prevalence and mortality of Granulomatosis with polyangiitis (GPA) in the United Kingdom. Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Epi... Read More about The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink.

Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008 (2016)
Journal Article
Hutchinson, J. P., McKeever, T. M., Fogarty, A. W., Navaratnam, V., & Hubbard, R. B. (in press). Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008. European Respiratory Journal, 48, https://doi.org/10.1183/13993003.00378-2016

Introduction: International guidelines and new targeted therapies for idiopathic pulmonary fibrosis have increased the need for accurate diagnosis of interstitial lung disease, which may lead to more surgical lung biopsies. This study aims to assess... Read More about Surgical lung biopsy for the diagnosis of interstitial lung disease in England: 1997-2008.

Bronchiectasis and the risk of cardiovascular disease: a population-based study (2016)
Journal Article
Navaratnam, V., Millett, E. R., Hurst, J. R., Thomas, S. L., Smeeth, L., Hubbard, R. B., …Quint, J. K. (in press). Bronchiectasis and the risk of cardiovascular disease: a population-based study. Thorax, 72(2), 161-166. https://doi.org/10.1136/thoraxjnl-2015-208188

Background: There are limited data on the burden of cardiovascular comorbidities in people with bronchiectasis. Our cross-sectional study estimates the burden of pre-existing diagnoses of coronary heart disease (CHD) and stroke in people with bronchi... Read More about Bronchiectasis and the risk of cardiovascular disease: a population-based study.

Place of death in patients with lung cancer: a retrospective cohort study from 2004-2013 (2016)
Journal Article
O'Dowd, E. L., McKeever, T. M., Baldwin, D. R., & Hubbard, R. B. (2016). Place of death in patients with lung cancer: a retrospective cohort study from 2004-2013. PLoS ONE, 11(8), 1-15. https://doi.org/10.1371/journal.pone.0161399

Introduction: Many patients with cancer die in an acute hospital bed, which has been frequently identified as the least preferred location, with psychological and financial implications. This study looks at place and cause of death in patients with l... Read More about Place of death in patients with lung cancer: a retrospective cohort study from 2004-2013.

Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population (2016)
Journal Article
Pearce, F. A., Lanyon, P. C., Grainge, M. J., Shaunak, R., Mahr, A., Hubbard, R. B., & Watts, R. A. (in press). Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population. Rheumatology, 55(9), https://doi.org/10.1093/rheumatology/kew232

Objectives: We aimed to estimate the incidence of ANCA-associated vasculitis in the UK and how this varied by ethnic group. Methods: We identified incident cases of ANCA-associated vasculitis between March 2007 and June 2013 in the Nottingham–Derby... Read More about Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population.

Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data (2016)
Journal Article
Walker, A. J., Baldwin, D. R., Card, T. R., Powell, H. A., Hubbard, R. B., & Grainge, M. J. (in press). Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data. British Journal of Cancer, 115(1), https://doi.org/10.1038/bjc.2016.143

Background: Venous thromboembolism is a potentially preventable cause of death in people with lung cancer. Identification of those most at risk and high risk periods may provide the opportunity for better targeted intervention. Methods: We conduc... Read More about Risk of venous thromboembolism in people with lung cancer: a cohort study using linked UK healthcare data.

Which patients are assessed by lung cancer nurse specialists? A national lung cancer audit study of over 128,000 patients across England (2016)
Journal Article
Khakwani, A., Hubbard, R. B., Beckett, P., Borthwick, D., Tod, A., Leary, A., …Tata, L. J. (in press). Which patients are assessed by lung cancer nurse specialists? A national lung cancer audit study of over 128,000 patients across England. Lung Cancer, 96, https://doi.org/10.1016/j.lungcan.2016.03.011

Background: Lung cancer nurse specialists (LCNS) are integral to the multidisciplinary clinical team, providing personalised physical and psycho-social interventions, and care management for people with lung cancer. The National Institute of Health a... Read More about Which patients are assessed by lung cancer nurse specialists? A national lung cancer audit study of over 128,000 patients across England.

Predicting death from surgery for lung cancer: a comparison of two scoring systems in two European countries (2016)
Journal Article
O'Dowd, E. L., Lüchtenborg, M., Baldwin, D. R., McKeever, T. M., Powell, H. A., Møller, H., …Hubbard, R. B. (2016). Predicting death from surgery for lung cancer: a comparison of two scoring systems in two European countries. Lung Cancer, 95, https://doi.org/10.1016/j.lungcan.2016.03.002

Objectives: Current British guidelines advocate the use of risk prediction scores such as Thoracoscore to estimate mortality prior to radical surgery for non-small cell lung cancer (NSCLC). A recent publication used the National Lung Cancer Audit (NL... Read More about Predicting death from surgery for lung cancer: a comparison of two scoring systems in two European countries.

Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study (2015)
Journal Article
Dallywater, W., Powell, H. A., Hubbard, R. B., & Navaratnam, V. (in press). Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study. Chest, 147(1), https://doi.org/10.1378/chest.14-0041

OBJECTIVE: People with idiopathic pulmonary fibrosis (IPF) have been shown to be at an increased risk for cardiovascular (CV) disease, but reasons for this are unknown. The aim of this study was to compare the prevalence of common CV risk factors in... Read More about Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population-based study.

In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011 (2015)
Journal Article
Hutchinson, J. P., Fogarty, A. W., McKeever, T. M., & Hubbard, R. B. (2016). In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011. American Journal of Respiratory and Critical Care Medicine, 193(10), 1161-1167. https://doi.org/10.1164/rccm.201508-1632OC

Rationale: Surgical lung biopsy can help to determine a specific diagnosis in interstitial lung disease, but has associated risks. Most currently available mortality data are derived from case series and may not be generalizable to broader population... Read More about In-hospital mortality following surgical lung biopsy for interstitial lung disease in the USA: 2000-2011.

Refining adverse drug reaction signals by incorporating interaction variables identified using emergent pattern mining (2015)
Journal Article
Reps, J. M., Aickelin, U., & Hubbard, R. B. (2016). Refining adverse drug reaction signals by incorporating interaction variables identified using emergent pattern mining. Computers in Biology and Medicine, 69, https://doi.org/10.1016/j.compbiomed.2015.11.014

Purpose: To develop a framework for identifying and incorporating candidate confounding interaction terms into a regularised cox regression analysis to refine adverse drug reaction signals obtained via longitudinal observational data. Methods: We co... Read More about Refining adverse drug reaction signals by incorporating interaction variables identified using emergent pattern mining.