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All Outputs (28)

Epigenetics and developmental programming of welfare and production traits in farm animals (2016)
Journal Article
Sinclair, K. D., Rutherford, K., Wallace, J., Brameld, J., Stöger, R., Alberio, R., …Dwyer, C. (in press). Epigenetics and developmental programming of welfare and production traits in farm animals. Reproduction, Fertility and Development, 28(10), https://doi.org/10.1071/RD16102

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referr... Read More about Epigenetics and developmental programming of welfare and production traits in farm animals.

Primordial germ cells: the first cell lineage or the last cells standing? (2015)
Journal Article
Johnson, A. D., & Alberio, R. (in press). Primordial germ cells: the first cell lineage or the last cells standing?. Development, 142, https://doi.org/10.1242/dev.113993

Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established. However, not all animals segregate their germ line in this... Read More about Primordial germ cells: the first cell lineage or the last cells standing?.

Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes (2015)
Journal Article
German, S. D., Lee, J., Campbell, K. H., Sweetman, D., & Alberio, R. (in press). Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes. Biology of Reproduction, 92(4), https://doi.org/10.1095/biolreprod.114.122341

Oocytes treated with the protein synthesis inhibitor cycloheximide (CHX) arrest at the germinal vesicle (GV) stage and undergo accelerated GV breakdown (GVBD) after CHX is removed. However, little is known about the underlying mechanism of accelerate... Read More about Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes.

Ovine induced pluripotent stem cells are resistant to reprogramming after nuclear transfer (2015)
Journal Article
German, S. D., Campbell, K. H., Thornton, E., McLachlan, G., Sweetman, D., & Alberio, R. (2015). Ovine induced pluripotent stem cells are resistant to reprogramming after nuclear transfer. Cellular Reprogramming, 17(1), https://doi.org/10.1089/cell.2014.0071

Induced pluripotent stem cells (iPSCs) share similar characteristics of indefinite in vitro growth with embryonic stem cells (ESCs) and may therefore serve as a useful tool for the targeted genetic modification of farm animals via nuclear transfer (N... Read More about Ovine induced pluripotent stem cells are resistant to reprogramming after nuclear transfer.

Modulation of pluripotency in the porcine embryo and iPS Cells (2012)
Journal Article
Rodríguez, A., Allegrucci, C., & Alberio, R. (2012). Modulation of pluripotency in the porcine embryo and iPS Cells. PLoS ONE, 7(11), Article 12. https://doi.org/10.1371/journal.pone.0049079

The establishment of the pluripotent ICM during early mammalian development is characterized by the differential expression of the transcription factors NANOG and GATA4/6, indicative of the epiblast and hypoblast, respectively. Differences in the mec... Read More about Modulation of pluripotency in the porcine embryo and iPS Cells.

Differential acetylation of histone H4 lysine during development of in vitro fertilized, cloned and parthenogenetically activated bovine embryos (2008)
Journal Article
Maalouf, W. E., Alberio, R., & Campbell, K. H. (2008). Differential acetylation of histone H4 lysine during development of in vitro fertilized, cloned and parthenogenetically activated bovine embryos. Epigenetics, 3(4), 199-209. https://doi.org/10.4161/epi.3.4.6497

The oocyte is remarkable in its ability to remodel parental genomes following fertilization and to reprogram somatic nuclei after nuclear transfer (NT). To characterize the patterns of histone H4 acetylation and DNA methylation during development of... Read More about Differential acetylation of histone H4 lysine during development of in vitro fertilized, cloned and parthenogenetically activated bovine embryos.