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All Outputs (27)

HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues (2017)
Journal Article
Qaiser, T., Mukherjee, A., Reddy Pb, C., Munugoti, S. D., Tallam, V., Pitkäaho, T., …Rajpoot, N. (2018). HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues. Histopathology, 72(2), 227-238. https://doi.org/10.1111/his.13333

Aims Evaluating expression of the Human epidermal growth factor receptor 2 (Her2) by visual examination of immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part of the diagnostic assessment of BCa due to its recognised importanc... Read More about HER2 challenge contest: a detailed assessment of automated HER2 scoring algorithms in whole slide images of breast cancer tissues.

Statistical colour models: an automated digital image analysis method for quantification of histological biomarkers (2016)
Journal Article
Shu, J., Dolman, G., Duan, J., Qiu, G., & Ilyas, M. (in press). Statistical colour models: an automated digital image analysis method for quantification of histological biomarkers. BioMedical Engineering OnLine, 15(1), https://doi.org/10.1186/s12938-016-0161-6

Background: Colour is the most important feature used in quantitative immunohisto- chemistry (IHC) image analysis; IHC is used to provide information relating to aetiology and to con rm malignancy. Methods: Statistical modelling is a technique widel... Read More about Statistical colour models: an automated digital image analysis method for quantification of histological biomarkers.

STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function (2014)
Journal Article
Ibrahem, S., Al‐Ghamdi, S., Baloch, K., Muhammad, B., Fadhil, W., Jackson, D., …Ilyas, M. (2014). STAT3 paradoxically stimulates β‐catenin expression but inhibits β‐catenin function. International Journal of Experimental Pathology, 95(6), 392-400. https://doi.org/10.1111/iep.12102

Wnt signalling and the signal transducer and activator of transcription 3 (STAT3) are oncogenic signalling pathways which are deregulated in colorectal cancer (CRC). Here we investigated the interaction of these two pathways. Firstly, we investigated... Read More about STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function.

DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy (2014)
Journal Article
Fadhil, W., Kindle, K., Jackson, D., Zaitoun, A. M., Lane, N., Robins, A., & Ilyas, M. (2014). DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy. International Journal of Experimental Pathology, 95(1), https://doi.org/10.1111/iep.12070

Colorectal cancers (CRC) are thought to have genetic instability in the form of either microsatellite instability (MSI) or chromosomal instability (CIN). Recently, tumours have been described without either MSI or CIN, that is, microsatellite and chr... Read More about DNA content analysis of colorectal cancer defines a distinct ‘microsatellite and chromosome stable’ group but does not predict response to radiotherapy.

A novel polar space random field model for the detection of glandular structures (2014)
Journal Article
Fu, H., Qiu, G., Shu, J., & Ilyas, M. (2014). A novel polar space random field model for the detection of glandular structures. IEEE Transactions on Medical Imaging, 33(3), 764-776. https://doi.org/10.1109/TMI.2013.2296572

In this paper, we propose a novel method to detect glandular structures in microscopic images of human tissue. We first convert the image from Cartesian space to polar space and then introduce a novel random field model to locate the possible boundar... Read More about A novel polar space random field model for the detection of glandular structures.

The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays (2013)
Journal Article
Tewari, N., Zaitoun, A. M., Arora, A., Madhusudan, S., Ilyas, M., & Lobo, D. N. (2013). The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays. BMC Cancer, 13, Article 436. https://doi.org/10.1186/1471-2407-13-436

Background Tumour-associated lymphocytes (TALs) have been linked with good prognosis in several solid tumours. This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma.... Read More about The presence of tumour-associated lymphocytes confers a good prognosis in pancreatic ductal adenocarcinoma: an immunohistochemical study of tissue microarrays.