Skip to main content

Research Repository

Advanced Search

All Outputs (37)

The placenta, maternal diet and adipose tissue development in the newborn (2017)
Journal Article
Symonds, M. E., Bloor, I., Ojha, S., & Budge, H. (2017). The placenta, maternal diet and adipose tissue development in the newborn. Annals of Nutrition and Metabolism, 70(3), 232-235. https://doi.org/10.1159/000464301

Background: A majority of adipose tissue present in the newborn possess the unique mitochondrial protein, uncoupling protein (UCP1). It is thus highly metabolically active and capable of producing 300 times more heat per unit mass than any other orga... Read More about The placenta, maternal diet and adipose tissue development in the newborn.

Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? (2016)
Journal Article
Aldiss, P., Budge, H., & Symonds, M. E. (2016). Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?. Cardiovascular Endocrinology, 5(4), 155-156. https://doi.org/10.1097/XCE.0000000000000089

Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the... Read More about Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?.

‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk (2016)
Journal Article
Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017). ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk. International Journal of Cardiology, 228, https://doi.org/10.1016/j.ijcard.2016.11.074

Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating... Read More about ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk.

Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma (2016)
Journal Article
Vergnes, L., Davies, G. R., Lin, J. Y., Yeh, M. W., Livhits, M. J., Harari, A., …Reue, K. (2016). Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma. Journal of Clinical Endocrinology and Metabolism, 101(11), https://doi.org/10.1210/jc.2016-2670

Context: Patients with pheochromocytoma (pheo) show presence of multilocular adipocytes that express uncoupling protein (UCP) 1 within periadrenal (pADR) and omental (OME) fat depots. It has been hypothesized that this is due to adrenergic stimula... Read More about Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma.

Gene pathway development in human epicardial adipose tissue during early life (2016)
Journal Article
Ojha, S., Fainberg, H. P., Wilson, V., Pelella, G., Castellanos, M., May, S., …Budge, H. (in press). Gene pathway development in human epicardial adipose tissue during early life. JCI insight, 1(13), Article e87460. https://doi.org/10.1172/jci.insight.87460

Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Here, we obtained samples of epicardial adipose tissue (EAT)... Read More about Gene pathway development in human epicardial adipose tissue during early life.

Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females (2016)
Journal Article
Robinson, L. J., Law, J., Symonds, M. E., & Budge, H. (2016). Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females. Experimental Physiology, 101(4), 549-557. https://doi.org/10.1113/EP085642

Brown adipose tissue (BAT) has been implicated in the pathogenesis of obesity, type 2 diabetes and the metabolic syndrome and is a potential therapeutic target. Brown adipose tissue can have a significant impact on energy balance and glucose homeosta... Read More about Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females.

Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes (2015)
Journal Article
Martino, J., Sebert, S., Segura, M. T., García-Valdés, L., Florido, J., Padilla, M. C., …Campoy, C. (2016). Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes. Journal of Clinical Endocrinology and Metabolism, 101(1), 59-68. https://doi.org/10.1210/jc.2015-2590

Context: Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.... Read More about Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes.

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans (2015)
Journal Article
Salem, V., Izzi‐Engbeaya, C., Coello, C., Thomas, D., Chambers, E., Comninos, A., …Dhillo, W. (2016). Glucagon increases energy expenditure independently of brown adipose tissue activation in humans. Diabetes, Obesity and Metabolism, 18(1), 72-81. https://doi.org/10.1111/dom.12585

Aims: To investigate, for a given energy expenditure (EE) rise, the differential effects of glucagon infusion and cold exposure on brown adipose tissue (BAT) activation in humans. Methods: Indirect calorimetry and supraclavicular thermography was pe... Read More about Glucagon increases energy expenditure independently of brown adipose tissue activation in humans.

Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children (2013)
Journal Article
Robinson, L., Ojha, S., Symonds, M., & Budge, H. (2014). Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children. Journal of Pediatrics, 164(2), 318-322.e1. https://doi.org/10.1016/j.jpeds.2013.10.005

Objective To determine whether body mass index (BMI) percentile and ethnicity influence skin temperature overlying brown adipose tissue (BAT) depots in the supraclavicular region in healthy children. Study design Infrared thermography measured s... Read More about Body Mass Index as a Determinant of Brown Adipose Tissue Function in Healthy Children.

Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa (2011)
Journal Article
Sebert, S., Dellschaft, N., Chan, L., Street, H., Henry, M., Francois, C., …Symonds, M. E. (2011). Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa. Endocrinology, 152(7), https://doi.org/10.1210/en.2011-0169

Fetal growth restriction followed by accelerated postnatal growth contributes to impaired metabolic function in adulthood. The extent to which these outcomes may be mediated centrally within the hypothalamus, as opposed to in the periphery within the... Read More about Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa.

Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity (2011)
Journal Article
Mistry, H. D., Mather, J., Ramsay, M. M., Kurlak, L. O., Symonds, M. E., & Broughton Pipkin, F. (2011). Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity. Pregnancy Hypertension, 1(2), https://doi.org/10.1016/j.preghy.2011.01.006

Pre-eclampsia affects between 2-7% of all pregnant women, contributing to perinatal and maternal morbidity. There are conflicting data on plasma homocysteine and folate in pre-eclampsia, and little about fetal concentrations. Objectives: Firstly, t... Read More about Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: influence of parity.

Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies (2008)
Journal Article
Mistry, H. D., Wilson, V., Ramsay, M. M., Symonds, M. E., & Broughton Pipkin, F. (2008). Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Hypertension, 52, https://doi.org/10.1161/HYPERTENSIONAHA.108.116103

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease. Selenium, act... Read More about Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies.

Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung (2007)
Journal Article
Yakubu, D., Mostyn, A., Hyatt, M., Kurlak, L., Budge, H., Stephenson, T., & Symonds, M. E. (2007). Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung. Reproduction, 134, https://doi.org/10.1530/REP-07-0155

This study investigated the developmental and nutritional programming of two important mitochondrial proteins, namely voltage dependent anion channel (VDAC) and cytochrome c in the sheep kidney, liver and lung. The effect of maternal nutrient restric... Read More about Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung.

Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep (2007)
Journal Article
Hyatt, M., Budge, H., Walker, D., Stephenson, T., & Symonds, M. E. (2007). Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep. Endocrinology, 148(10), https://doi.org/10.1210/en.2007-0303

The liver is an important metabolic and endocrine organ in the fetus but the extent to which its hormone receptor (R) sensitivity is developmentally regulated in early life is not fully established. We, therefore, examined developmental changes in mR... Read More about Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep.

Effect of maternal cold exposure and nutrient restriction on insulin-like growth factor sensitivity in adipose tissue of newborn sheep (2007)
Journal Article
Butt, E., Hyatt, M., Budge, H., Symonds, M., & Stephenson, T. (2007). Effect of maternal cold exposure and nutrient restriction on insulin-like growth factor sensitivity in adipose tissue of newborn sheep

Adipose tissue mass in the newborn is determined in part by insulin-like growth factor (IGF)s, which are dependent on the maternal nutritional and metabolic environment during late gestation. The present study was designed to determine whether matern... Read More about Effect of maternal cold exposure and nutrient restriction on insulin-like growth factor sensitivity in adipose tissue of newborn sheep.