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All Outputs (51)

Evidence around early induction of labor in women of advanced maternal age and those using assisted reproductive technology (2021)
Journal Article
Venkatanarayanan, N., & Walker, K. F. (2021). Evidence around early induction of labor in women of advanced maternal age and those using assisted reproductive technology. Best Practice and Research: Clinical Obstetrics and Gynaecology, 77, 42-52. https://doi.org/10.1016/j.bpobgyn.2021.08.007

Worldwide, there has been a trend toward later motherhood. Concurrently, the incidence of subfertility has been on the rise, necessitating conception using assisted reproductive technologies (ARTs). These pregnancies are considered high risk due to f... Read More about Evidence around early induction of labor in women of advanced maternal age and those using assisted reproductive technology.

Episiotomy and Initiation of Human Milk Feeds: A Retrospective Observational Study (2021)
Journal Article
Servante, J., Abramson, J., Walker, K. F., & Ojha, S. (2021). Episiotomy and Initiation of Human Milk Feeds: A Retrospective Observational Study. Breastfeeding Medicine, 16(5), 407-413. https://doi.org/10.1089/bfm.2020.0071

Objective: To investigate the association, in the United Kingdom, between having an episiotomy during childbirth and giving human milk by any modality as an infant's first feed. We also identified maternal demographic factors and perinatal experience... Read More about Episiotomy and Initiation of Human Milk Feeds: A Retrospective Observational Study.

Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation (2021)
Journal Article
Suthaporn, S., Jayaprakasan, K., Thornton, J. G., Walker, K. F., Castellanos, M., May, S., …Maalouf, W. E. (2021). Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation. Molecular and Cellular Endocrinology, 528, Article 111242. https://doi.org/10.1016/j.mce.2021.111242

This study aimed to evaluate the influence of progesterone (concentration and time of exposure) on endometrial decidualisation using an in vitro model cell line: Human Endometrial Stromal Cells (HESCs). HESCs exposed to progesterone (1 and 10 μM) had... Read More about Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation.

The acceptability to women of techniques for managing an impacted fetal head at caesarean section and of randomised trials evaluating those techniques: a qualitative study (2021)
Journal Article
Romano, G., Mitchell, E., Plachcinski, R., Wakefield, N., Walker, K., & Ayers, S. (2021). The acceptability to women of techniques for managing an impacted fetal head at caesarean section and of randomised trials evaluating those techniques: a qualitative study. BMC Pregnancy and Childbirth, 21, Article 103. https://doi.org/10.1186/s12884-021-03577-z

Background This study aimed to explore women’s views on the acceptability of different techniques for managing an impacted fetal head at caesarean; and the feasibility and acceptability of conducting a trial in this area. Methods Qualitative sem... Read More about The acceptability to women of techniques for managing an impacted fetal head at caesarean section and of randomised trials evaluating those techniques: a qualitative study.

The challenges of randomised control trials in obstetrics and gynaecology (2021)
Journal Article
Harper, S. L., Thornton, J. G., & Walker, K. F. (2021). The challenges of randomised control trials in obstetrics and gynaecology. Obstetrics, Gynaecology and Reproductive Medicine, 31(2), 59-60. https://doi.org/10.1016/j.ogrm.2020.12.006

In this short article we explore some of the challenges faced by those conducting randomised trials in obstetrics and gynaecology. We discuss the current status of trials comparing induction of labour versus expectant management, so called ‘deliver o... Read More about The challenges of randomised control trials in obstetrics and gynaecology.

Fetal Movement Counting Using Optical Fibre Sensors (2020)
Journal Article
Abeywardena, C. L., Vanheusden, F. J., Walker, K. F., Arm, R., & Zhang, Q. (2021). Fetal Movement Counting Using Optical Fibre Sensors. Sensors, 21(1), 1-14. https://doi.org/10.3390/s21010048

Daily fetal movement counting based on maternal perception is widely deployed to monitor fetal wellbeing. However, the counting performed by the mother is prone to errors for various reasons. There are limited devices on the market that can provide r... Read More about Fetal Movement Counting Using Optical Fibre Sensors.

Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure (2020)
Journal Article
Suthaporn, S., Jayaprakasan, K., Thornton, J., Walker, K., Medrano, J. H., Castellanos, M., …Maalouf, W. E. (2021). Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure. Reproductive BioMedicine Online, 42(3), 595-608. https://doi.org/10.1016/j.rbmo.2020.10.018

Research question What is the difference in endometrial transcriptomics between women with normal and with low mid-luteal progesterone during the implantation window? Design An endometrial biopsy and serum progesterone concentration were taken f... Read More about Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure.

Maternal transmission of SARS?COV?2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis (2020)
Journal Article
Walker, K., O'Donoghue, K., Grace, N., Dorling, J., Comeau, J. L., Li, W., & Thornton, J. (2020). Maternal transmission of SARS?COV?2 to the neonate, and possible routes for such transmission: a systematic review and critical analysis. BJOG: An International Journal of Obstetrics and Gynaecology, 127(11), 1324-1336. https://doi.org/10.1111/1471-0528.16362

Timing and mode of delivery with advancing maternal age (2020)
Journal Article
Walker, K. F., & Thornton, J. G. (2021). Timing and mode of delivery with advancing maternal age. Best Practice and Research: Clinical Obstetrics and Gynaecology, 70, 101-111. https://doi.org/10.1016/j.bpobgyn.2020.06.005

In 2017, 23% of all live births in the United Kingdom were to women aged over 35 years. Decisions around the timing of delivery for such women must balance the risks of prolongation of the pregnancy and of iatrogenic harm from timed delivery. Women o... Read More about Timing and mode of delivery with advancing maternal age.

The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: a systematic review (2020)
Journal Article
Robinson, R., Walker, K. F., White, V. A., Bugg, G. J., Snell, K. I., & Jones, N. W. (2020). The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: a systematic review. European Journal of Obstetrics and Gynecology and Reproductive Biology, 246, P79-85. https://doi.org/10.1016/j.ejogrb.2020.01.019

Objectives To determine which ultrasound measurement for predicted fetal macrosomia most accurately predicts adverse delivery and neonatal outcomes. Study Design Four biomedical databases searched for studies published after 1966. Randomised tr... Read More about The test accuracy of antenatal ultrasound definitions of fetal macrosomia to predict birth injury: a systematic review.

The strength of evidence supporting luteal phase progestogen after assisted reproduction: A systematic review with reference to trial registration and pre-specified endpoints (2019)
Journal Article
Suthaporn, S., Jayaprakasan, K., Maalouf, W., Thornton, J. G., & Walker, K. F. (2020). The strength of evidence supporting luteal phase progestogen after assisted reproduction: A systematic review with reference to trial registration and pre-specified endpoints. European Journal of Obstetrics and Gynecology and Reproductive Biology, 245, 149-161. https://doi.org/10.1016/j.ejogrb.2019.12.002

Childbirth experience questionnaire 2: Validating its use in the United Kingdom (2019)
Journal Article
Walker, K. F., Dencker, A., & Thornton, J. G. (2020). Childbirth experience questionnaire 2: Validating its use in the United Kingdom. European Journal of Obstetrics && Gynecology and Reproductive Biology: X, 5, Article 100097. https://doi.org/10.1016/j.eurox.2019.100097

© 2019 The Authors Objective: To validate the Childbirth Experience Questionnaire 2 (CEQ2) in the UK to see if it is an effective tool for evaluating labour experience. Study design: The CEQ2 and part of the Care Quality Commission Maternity Survey (... Read More about Childbirth experience questionnaire 2: Validating its use in the United Kingdom.

Advanced maternal age (2019)
Journal Article
Walker, K. F., & Thornton, J. G. (2019). Advanced maternal age. Obstetrics, Gynaecology and Reproductive Medicine, 29(9), 259-263. https://doi.org/10.1016/j.ogrm.2019.06.001

The average age of women at childbirth in industrialised nations has been increasing steadily for approximately 30 years. Women aged 35 years or over have an increased risk of gestational hypertensive disease, gestational diabetes, placenta praevia,... Read More about Advanced maternal age.

Is it time to ban oxytocin for poor labour progress? (2019)
Journal Article
Walker, K. F., & Bugg, G. (2019). Is it time to ban oxytocin for poor labour progress?. Obstetrics, Gynaecology and Reproductive Medicine, 29(6), 175-176. https://doi.org/10.1016/j.ogrm.2019.03.002

Oxytocin causes myometrial contractions and prostaglandin release. It is commonly used as an intervention for women in established labour with slow progress. However recent large randomised trials of oxytocin for this indication have shown no differe... Read More about Is it time to ban oxytocin for poor labour progress?.

Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting (2019)
Journal Article
White, V. A., Walker, K. F., & Thornton, J. G. (2019). Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting. European Journal of Obstetrics and Gynecology and Reproductive Biology, 236, 58-68. https://doi.org/10.1016/j.ejogrb.2019.02.031

Objective To measure the extent to which the evidence underpinning prenatal corticosteroids for preterm fetal lung maturity is at risk of bias due to selective outcome reporting. Study Design Five biomedical databases (Medline, ClinicalTrials.gov,... Read More about Trials of antenatal corticosteroids for preterm fetal lung maturity: a review of the potential for selective outcome reporting.

Maternal position in the second stage of labour for women with epidural anaesthesia (2018)
Journal Article
Walker, K. F., Kibuka, M., Thornton, J. G., & Jones, N. W. (2018). Maternal position in the second stage of labour for women with epidural anaesthesia. Cochrane Database of Systematic Reviews, 2018(11), Article CD008070. https://doi.org/10.1002/14651858.CD008070.pub4

© 2018 The Cochrane Collaboration. Background: Epidural analgesia in labour prolongs the second stage and increases instrumental delivery. It has been suggested that a more upright maternal position during all or part of the second stage may counter... Read More about Maternal position in the second stage of labour for women with epidural anaesthesia.

Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study (2018)
Journal Article
Whitham, D., Turzanski, J., Bradshaw, L., Clarke, M., Culliford, L., Duley, L., …Wood, J. (2018). Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study. Trials, 19, Article 557. https://doi.org/10.1186/s13063-018-2940-9

Background Site performance is key to the success of large multicentre randomised trials. A standardised set of clear and accessible summaries of site performance could facilitate the timely identification and resolution of potential problems, minim... Read More about Development of a standardised set of metrics for monitoring site performance in multicentre randomised trials: a Delphi study.

Monitoring performance of sites within multicentre randomised trials: a systematic review of performance metrics (2018)
Journal Article
Walker, K. F., Turzanski, J., Whitham, D., Montgomery, A., & Duley, L. (2018). Monitoring performance of sites within multicentre randomised trials: a systematic review of performance metrics. Trials, 19, Article 562. https://doi.org/10.1186/s13063-018-2941-8

© 2018 The Author(s). Background: Large multicentre trials are complex and expensive projects. A key factor for their successful planning and delivery is how well sites meet their targets in recruiting and retaining participants, and in collecting hi... Read More about Monitoring performance of sites within multicentre randomised trials: a systematic review of performance metrics.