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All Outputs (63)

Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin) (2019)
Journal Article
Ghoz, N., Britton, J., Ross, A. R., Mohammed, I., Hogan, E., Said, D. G., & Dua, H. S. (2019). Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin). Eye, 33(11), 1776-1783. https://doi.org/10.1038/s41433-019-0493-0

Background To assess the efficacy of combined 5FU and Avastin injections in the treatment of primary pterygium Methods Sixteen eyes with primary pterygium received intralesional 5 fluorouracil and Avastin (2.5–5 mg) injections every 2 weeks... Read More about Management of primary pterygium with intra-lesional injection of 5 flurouracil and bevacizumab (Avastin).

Corneal nerves in health and disease (2019)
Journal Article
Al Aqaba, M. A., Dhillon, V. K., Mohammed, I., Said, D. G., & Dua, H. S. (2019). Corneal nerves in health and disease. Progress in Retinal and Eye Research, 73, Article 100762. https://doi.org/10.1016/j.preteyeres.2019.05.003

The cornea is the most sensitive structure in the human body. Corneal nerves adapt to maintain transparency and contribute to corneal health by mediating tear secretion and protective reflexes and provide trophic support to epithelial and stromal cel... Read More about Corneal nerves in health and disease.

In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft (2018)
Journal Article
Rose, J., Sidney, L., Patient, J., White, L., Dua, H., El Haj, A., …Rose, F. (2018). In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft. Journal of Biomedical Materials Research Part A, 107(4), 828-838. https://doi.org/10.1002/jbm.a.36598

The advent of innovative surgical procedures utilizing partial thickness corneal grafts has created a need for the development of synthetic implants to recreate corneal stromal tissue. This work evaluates electrospun gelatin and polycaprolactone (PCL... Read More about In vitro evaluation of electrospun blends of gelatin and PCL for application as a partial thickness corneal graft.

Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus (2018)
Journal Article
Said, D. G., Ross, A. R., Messina, M., Mohammed, I., & Dua, H. (2018). Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus. Eye, doi:10.1038/s41433-018-0211-3

Corneal collagen cross-linking (CXL) is the only treatment that delays or arrests progression of keratoconus. CXL is a safe procedure with few complications. CXL protocols vary depending on time and energy used but all are safe and effective. Variati... Read More about Localised corneal haze and scarring following pulsed accelerated collagen cross-linking for keratoconus.

In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy (2018)
Journal Article
Mastropasqua, L., Nubile, M., Lanzini, M., Calienno, R., & Dua, H. S. (2019). In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy. Journal of Cellular Physiology, 234(5), 6108-6115. https://doi.org/10.1002/jcp.27345

© 2018 Wiley Periodicals, Inc. Neurotrophic keratopathy (NK) is a rare degenerative corneal disorder characterized by instability of epithelial integrity with consequent epithelial defects that can worsen up to persistent epithelial defects with stro... Read More about In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy.

Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study (2018)
Journal Article
Wilde, C., Awad, M., Dua, H., Gandhewar, R., Chen, H., & Amoaku, W. M. (2018). Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study. Ophthalmology Retina, 2(12), 1218-1226. https://doi.org/10.1016/j.oret.2018.06.009

© 2018 Purpose: To evaluate outcomes of epiretinal membrane (ERM) surgery in eyes with subretinal drusenoid deposits (SRDDs) and to compare them with those with isolated ERM. Design: Retrospective case-control study of consecutive patients who underw... Read More about Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study.

Healing of autologous conjunctival grafts in pterygium surgery (2018)
Journal Article
Ghoz, N., Elalfy, M., Said, D., & Dua, H. (2018). Healing of autologous conjunctival grafts in pterygium surgery. Acta Ophthalmologica, 96(8), e979-e988. https://doi.org/10.1111/aos.13794

Purpose To temporally study the healing of conjunctival autografts in consecutive patients following pterygium surgery. Methods A case?cohort observational study. Thirty?two eyes of 28 patients who underwent pterygium surgery were included. All... Read More about Healing of autologous conjunctival grafts in pterygium surgery.

Lamellar keratoplasty techniques (2018)
Journal Article
Dua, H. S., Singh, N., & Said, D. (2018). Lamellar keratoplasty techniques. Indian Journal of Ophthalmology, 66(9), 1239-1250. https://doi.org/10.4103/ijo.IJO_95_18

© 2018 Indian Journal of Ophthalmology. Lamellar keratoplasty (LK) has revolutionized corneal graft surgery in several ways. Deep anterior LK (DALK) has eliminated risk of failure due to endothelial rejection. Endothelial keratoplasty (EK) has almost... Read More about Lamellar keratoplasty techniques.

Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling (2018)
Journal Article
Mohammed, I., Ross, A. R., Britton, J. O., Said, D. G., & Dua, H. S. (2018). Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling. American Journal of Ophthalmology, 194, 16-25. https://doi.org/10.1016/j.ajo.2018.07.001

Purpose Descemet membrane endothelial keratoplasty (DMEK) and pre-Descemet endothelial keratoplasty (PDEK) tissues always scroll with the endothelial cells (EC) outside. We designed a study to understand the reason for this behavior. Design... Read More about Elastin content and distribution in endothelial keratoplasty tissue determines direction of scrolling.

Neurotrophic keratopathy (2018)
Journal Article
Dua, H. S., Said, D. G., Messmer, E. M., Rolando, M., Benitez-del-Castillo, J. M., Hossain, P. N., …Baudouin, C. (2018). Neurotrophic keratopathy. Progress in Retinal and Eye Research, 66, 107-131. https://doi.org/10.1016/j.preteyeres.2018.04.003

Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor... Read More about Neurotrophic keratopathy.

Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different (2018)
Journal Article
Ross, A. R., Said, D. G., El-Amin, A., Altaan, S., Cabrerizo, J., Nubile, M., …Dua, H. S. (2018). Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different. British Journal of Ophthalmology, 102(12), 1646-1652. https://doi.org/10.1136/bjophthalmol-2017-311349

Aims: To investigate and define the nature of big bubbles (BB) formed by injection of viscoelastic in deep anterior lamellar keratoplasty. Methods: Intrastromal injections of 0.1 and 0.3 mL of sodium hyaluronate 1.2% and 0.6% were made into sclera... Read More about Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different.

Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology (2018)
Journal Article
Messina, M., & Dua, H. S. (2019). Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology. International Ophthalmology, 39(3), 693-696. https://doi.org/10.1007/s10792-018-0843-0

Purpose To evaluate the effect of once daily administration of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease (DED). Methods Eighteen patients (3 male, 15 female) aged 25–86 years (mean 61.1) and suffering from moder... Read More about Early results on the use of chitosan-N-acetylcysteine (Lacrimera®) in the management of dry eye disease of varied etiology.

Nerve terminals at the human corneoscleral limbus (2017)
Journal Article
Al -Aqaba, M., Anis, F. S., Mohammed, I., & Dua, H. S. (2017). Nerve terminals at the human corneoscleral limbus. British Journal of Ophthalmology, 102(4), 556-561. doi:10.1136/bjophthalmol-2017-311146

Aims: To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus. Methods: Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age,... Read More about Nerve terminals at the human corneoscleral limbus.

Survival of corneal nerve/sheath structures in organ-cultured donor corneas (2017)
Journal Article
Dhillon, V. K., Elalfy, M. S., Messina, M., Al-Aqaba, M., & Dua, H. S. (2018). Survival of corneal nerve/sheath structures in organ-cultured donor corneas. Acta Ophthalmologica, 96(3), e334-e340. doi:10.1111/aos.13614

Purpose To study the morphology of human corneal nerves in eye bank organ‐cultured corneas and in corneal grafts post‐transplantation. Methods Thirty‐seven organ‐cultured corneas were divided into: Group‐A, anterior 300–400 μm of 20 corneas used... Read More about Survival of corneal nerve/sheath structures in organ-cultured donor corneas.

Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study (2017)
Journal Article
AlTaan, S., Mohammed, I., Said, D., & Dua, H. (2018). Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study. Eye, 32(1), 146-151. https://doi.org/10.1038/eye.2017.121

Purpose: To measure the pressure and volume of air required to create a big bubble (BB) in simulated deep anterior lamellar keratoplasty (DALK) in donor eyes and ascertain the bursting pressure of the BB. Patients and methods: Twenty-two human scler... Read More about Air pressure changes in the creation and bursting of the type-1 big bubble in deep anterior lamellar keratoplasty: an ex vivo study.

Human antimicrobial peptides in ocular surface defense (2017)
Journal Article
Mohammed, I., Said, D. G., & Dua, H. S. (2017). Human antimicrobial peptides in ocular surface defense. Progress in Retinal and Eye Research, 61, (1-22). doi:10.1016/j.preteyeres.2017.03.004. ISSN 1350-9462

Sight depends on the passage of light through the transparent cornea and being focused on the fovea. Its exposed position renders it vulnerable to microbial infection. The cornea has developed a wide array of defense mechanisms against infection, of... Read More about Human antimicrobial peptides in ocular surface defense.

3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review (2017)
Journal Article
Prina, E., Mistry, P., Sidney, L. E., Yang, J., Wildman, R. D., Bertolin, M., …Rose, F. R. A. (2017). 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review. Stem Cell Reviews and Reports, 13(3), 430-441. https://doi.org/10.1007/s12015-017-9740-6

In recent years, there has been increased research interest in generating corneal substitutes, either for use in the clinic or as in vitro corneal models. The advancement of 3D microfabrication technologies has allowed the reconstruction of the nativ... Read More about 3D microfabricated scaffolds and microfluidic devices for ocular surface replacement: a review.