All Outputs (135)

Terrestrial runoff influences the transport and contamination levels of Toxoplasma gondii in marine organisms (2022)
Journal Article
Li, M. Y., Kang, Y. H., Sun, W. C., Hao, Z. P., Elsheikha, H. M., & Cong, W. (2022). Terrestrial runoff influences the transport and contamination levels of Toxoplasma gondii in marine organisms. Science of the Total Environment, 851, Article 158168. https://doi.org/10.1016/j.scitotenv.2022.158168

There is a growing concern regarding the potential adverse impact of Toxoplasma gondii contamination of the marine environment on marine wildlife and public health. Terrestrial runoff is a significant route for dissemination of T. gondii oocysts from... Read More about Terrestrial runoff influences the transport and contamination levels of Toxoplasma gondii in marine organisms.

Perception of UK companion animal veterinarians on risk assessment based parasite control (2022)
Journal Article
Bagster, A., & Elsheikha, H. (2022). Perception of UK companion animal veterinarians on risk assessment based parasite control. Veterinary parasitology (Amsterdam), 34, Article 100774. https://doi.org/10.1016/j.vprsr.2022.100774

Parasites can pose a risk to companion animals and potentially their owners. Current parasiticide use is possibly impacting the environment, increasing adverse reaction and resistance risk. As such parasiticides should be dispensed by the veterinary... Read More about Perception of UK companion animal veterinarians on risk assessment based parasite control.

RNA sequencing reveals dynamic expression of spleen lncRNAs and mRNAs in Beagle dogs infected by Toxocara canis (2022)
Journal Article
Xu, Y., Zheng, W. B., Li, H. Y., Cai, L., Zou, Y., Xie, S. C., …Elsheikha, H. M. (2022). RNA sequencing reveals dynamic expression of spleen lncRNAs and mRNAs in Beagle dogs infected by Toxocara canis. Parasites and Vectors, 15(1), Article 279. https://doi.org/10.1186/s13071-022-05380-x

Background: Toxocara canis is a cosmopolitan parasite with a significant adverse impact on the health of humans and animals. The spleen is a major immune organ that plays essential roles in protecting the host against various infections. However, its... Read More about RNA sequencing reveals dynamic expression of spleen lncRNAs and mRNAs in Beagle dogs infected by Toxocara canis.

Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach (2022)
Journal Article
Bouten, M., & Elsheikha, H. M. (2022). Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach. Parasitologia, 2(3), 167-197. https://doi.org/10.3390/parasitologia2030016

Acanthamoeba keratitis (AK) is a potentially blinding infection caused by protozoa found worldwide. The topical application of biguanides and diamidines is the most common anti-amoebic treatment for AK. In this study, we hypothesized that geographica... Read More about Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach.

Human pediculosis, a global public health problem (2022)
Journal Article
Fu, Y., Yao, C., Deng, Y., Elsheikha, H. M., Shao, R., Zhu, X., & Liu, G. (2022). Human pediculosis, a global public health problem. Infectious Diseases of Poverty, 11(1), Article 58. https://doi.org/10.1186/s40249-022-00986-w

Background: Human pediculosis is caused by hematophagous lice, which are transmitted between individuals via direct and/or indirect contact. Despite the public health importance of louse infestation, information concerning the global burden of pedicu... Read More about Human pediculosis, a global public health problem.

Global profiling of protein lysine malonylation in Toxoplasma gondii strains of different virulence and genetic backgrounds (2022)
Journal Article
Nie, L., Liang, Q., Wang, M., Du, R., Zhang, M., Elsheikha, H. M., & Zhu, X. (2022). Global profiling of protein lysine malonylation in Toxoplasma gondii strains of different virulence and genetic backgrounds. PLoS Neglected Tropical Diseases, 16(5), Article e0010431. https://doi.org/10.1371/journal.pntd.0010431

Lysine malonylation is a post-translational modification (PTM), which regulates many cellular processes. Limited information is available about the level of lysine malonylation variations between Toxoplasma gondii strains of distinct genetic lineages... Read More about Global profiling of protein lysine malonylation in Toxoplasma gondii strains of different virulence and genetic backgrounds.

Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy (2022)
Journal Article
Elsheikha, H. M., Al-Sandaqchi, A. T., Harun, M. S., Winterton, F., Altharawi, A., Elsaied, N. A., …Chan, K. L. A. (2022). Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy. Cells, 11(5), Article 811. https://doi.org/10.3390/cells11050811

Toxoplasma gondii (T. gondii) is an opportunistic protozoan that can cause brain infection and other serious health consequences in immuno-compromised individuals. This parasite has a remarkable ability to cross biological barriers and exploit the ho... Read More about Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy.

A systematic review, meta‐analysis and meta‐regression of the global prevalence of Toxoplasma gondii infection in wild marine mammals and associations with epidemiological variables (2022)
Journal Article
Li, M., Gao, X., Ma, J., Elsheikha, H. M., & Cong, W. (2022). A systematic review, meta‐analysis and meta‐regression of the global prevalence of Toxoplasma gondii infection in wild marine mammals and associations with epidemiological variables. Transboundary and Emerging Diseases, 69(5), e1213-e1230. https://doi.org/10.1111/tbed.14493

Toxoplasma gondii infection in wild marine mammals is a growing problem and is associated with adverse impacts on marine animal and public health. This systematic review, meta-analysis and meta-regression estimates the global prevalence of T. gondii... Read More about A systematic review, meta‐analysis and meta‐regression of the global prevalence of Toxoplasma gondii infection in wild marine mammals and associations with epidemiological variables.

Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System (2022)
Journal Article
Liang, Q. L., Nie, L. B., Li, T. T., Elsheikha, H. M., Sun, L. X., Zhang, Z. W., …Wang, J. L. (2022). Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System. Frontiers in Cell and Developmental Biology, 9, Article 738794. https://doi.org/10.3389/fcell.2021.738794

Protein serine/threonine phosphatases (PSPs), found in various plants and protozoa, are involved in the regulation of various biological processes. However, very little is known about the role of PSPs in the pathogenicity of the apicomplexan protozoa... Read More about Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System.

Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle (2022)
Journal Article
Wang, S. S., Zhou, C. X., Elsheikha, H. M., He, J. J., Zou, F. C., Zheng, W. B., …Zhao, G. H. (2022). Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle. Parasites and Vectors, 15, Article 22. https://doi.org/10.1186/s13071-021-05140-3

Background: Long non-coding RNAs (lncRNAs) are important regulators of various biological and pathological processes, in particular the inflammatory response by modulating the transcriptional control of inflammatory genes. However, the role of lncRNA... Read More about Temporal transcriptomic changes in long non-coding RNAs and messenger RNAs involved in the host immune and metabolic response during Toxoplasma gondii lytic cycle.

Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors (2021)
Journal Article
Zhu, Y. C., Elsheikha, H. M., Wang, J. H., Fang, S., He, J. J., Zhu, X. Q., & Chen, J. (2021). Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors. Journal for ImmunoTherapy of Cancer, 9(11), Article e002970. https://doi.org/10.1136/jitc-2021-002970

Background: In this study, we hypothesize that the ability of the protozoan Toxoplasma gondii to modulate immune response within the tumor might improve the therapeutic effect of immune checkpoint blockade. We examined the synergetic therapeutic acti... Read More about Synergy between Toxoplasma gondii type I Δ GRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors.

Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination (2021)
Journal Article
Ma, J. Y., Li, M. Y., Qi, Z. Z., Fu, M., Sun, T. F., Elsheikha, H. M., & Cong, W. (2022). Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination. Science of the Total Environment, 806(Part 2), Article 150562. https://doi.org/10.1016/j.scitotenv.2021.150562

The aim of this review is to identify the worldwide trend of waterborne protozoan outbreaks and how it varies between geographic regions during the period from 2017 to 2020. Data about waterborne protozoan outbreaks were gathered and stratified by co... Read More about Waterborne protozoan outbreaks: An update on the global, regional, and national prevalence from 2017 to 2020 and sources of contamination.

Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow (2021)
Journal Article
Zheng, W. B., Zou, Y., Liu, Q., Hu, M. H., Elsheikha, H. M., & Zhu, X. Q. (2021). Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow. Frontiers in Cell and Developmental Biology, 9, Article 688128. https://doi.org/10.3389/fcell.2021.688128

Bone marrow is the main hematopoietic organ that produces red blood cells, granulocytes, monocyte/macrophages, megakaryocytes, lymphocytes, and myeloid dendritic cells. Many of these cells play roles in the pathogenesis of Toxocara canis infection, a... Read More about Toxocara canis Infection Alters lncRNA and mRNA Expression Profiles of Dog Bone Marrow.

Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses (2021)
Journal Article
Cong, W., & Elsheikha, H. M. (2021). Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses. Yale Journal of Biology and Medicine, 94(2), 297-309

Fish-borne parasites have been part of the global landscape of food-borne zoonotic diseases for many decades and are often endemic in certain regions of the world. The past 20 years or so have seen the expansion of the range of fish-borne parasitic z... Read More about Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses.

Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells (2021)
Journal Article
Wang, S. S., Chen, D., He, J. J., Zheng, W. B., Tian, A. L., Zhao, G. H., …Zhu, X. Q. (2021). Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells. Frontiers in Immunology, 12, Article 653755. https://doi.org/10.3389/fimmu.2021.653755

Fasciola gigantica produces excretory-secretory products (ESPs) with immune-modulating effects to promote its own survival. In this study, we performed RNA-seq to gain a comprehensive global understanding of changes in the expression of mRNAs, miRNAs... Read More about Fasciola gigantica–Derived Excretory-Secretory Products Alter the Expression of mRNAs, miRNAs, lncRNAs, and circRNAs Involved in the Immune Response and Metabolism in Goat Peripheral Blood Mononuclear Cells.

Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis? (2021)
Journal Article
Cooper, E., Cowmeadow, W., & Elsheikha, H. M. (2021). Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?. Parasitologia, 1(1), 12-19. https://doi.org/10.3390/parasitologia1010002

When presented with an animal exhibiting signs of keratitis (inflammation of the cornea), such as impaired vision, mucoid discharges, redness, swelling, and corneal oedema, most veterinarians would think of bacteria, viruses, or fungi as the potentia... Read More about Should Veterinary Practitioners Be Concerned about Acanthamoeba Keratitis?.

Human gnathostomiasis: a neglected food-borne zoonosis (2020)
Journal Article
Liu, G., Sun, M., Elsheikha, H. M., Fu, Y., Sugiyama, H., Ando, K., …Yao, C. (2020). Human gnathostomiasis: a neglected food-borne zoonosis. Parasites and Vectors, 13, Article 616. https://doi.org/10.1186/s13071-020-04494-4

Background: Human gnathostomiasis is a food-borne zoonosis. Its etiological agents are the third-stage larvae of Gnathostoma spp. Human gnathostomiasis is often reported in developing countries, but it is also an emerging disease in developed countri... Read More about Human gnathostomiasis: a neglected food-borne zoonosis.

Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica (2020)
Journal Article
Shi, W., He, J., Mei, X., Lu, K., Zeng, Z., Zhang, Y., …Zhu, X. (2020). Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica. PLoS Neglected Tropical Diseases, 14(12), Article e0008951. https://doi.org/10.1371/journal.pntd.0008951

The excretory-secretory products released by the liver fluke Fasciola gigantica (FgESPs) play important roles in regulating the host immune response during the infection. Identification of hepatic miRNAs altered by FgESPs may improve our understandin... Read More about Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica.

ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell (2020)
Journal Article
Li, J., He, J., Elsheikha, H. M., Ma, J., Xu, X., & Zhu, X. (2020). ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell. Frontiers in Cellular and Infection Microbiology, 10, Article 586946. https://doi.org/10.3389/fcimb.2020.586946

Toxoplasma gondii secretes a number of virulence-related effector proteins, such as the rhoptry protein 18 (ROP18). To further broaden our understanding of the molecular functions of ROP18, we examined the transcriptional response of human embryonic... Read More about ROP18-Mediated Transcriptional Reprogramming of HEK293T Cell Reveals New Roles of ROP18 in the Interplay Between Toxoplasma gondii and the Host Cell.

Molecular prevalence, risk factors and genotypes of Toxoplasma gondii DNA in wild marine snails collected from offshore waters in eastern China (2020)
Journal Article
Cong, W., Elsheikha, H. M., Li, M., Ma, J., Zou, Y., & Jiang, Z. (2021). Molecular prevalence, risk factors and genotypes of Toxoplasma gondii DNA in wild marine snails collected from offshore waters in eastern China. Acta Tropica, 214, https://doi.org/10.1016/j.actatropica.2020.105779

Increasing evidence exisits for the role that shellfish play in the epidemiology of Toxoplasma gondii in marine environment. However, limited information is available on the level of T. gondii infection in wild marine snails, which can play a role in... Read More about Molecular prevalence, risk factors and genotypes of Toxoplasma gondii DNA in wild marine snails collected from offshore waters in eastern China.