Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis
(2021)
Journal Article
Shipley, L., Mistry, A., & Sharkey, D. (2021). Outcomes of neonatal hypoxic-ischaemic encephalopathy in centres with and without active therapeutic hypothermia: a nationwide propensity score-matched analysis. Archives of Disease in Childhood. Fetal and Neonatal Edition, Article fetalneonatal-2020-320966. https://doi.org/10.1136/archdischild-2020-320966
All Outputs (40)
Airflow dispersion during common neonatal resuscitation procedures: A simulation study (2021)
Journal Article
Kwok, T. C., Swaby, R., & Sharkey, D. (2021). Airflow dispersion during common neonatal resuscitation procedures: A simulation study. Pediatric Pulmonology, 56(7), 2057-2066. https://doi.org/10.1002/ppul.25378Background Aerosol generating medical procedures (AGMPs) are common during newborn resuscitation. Neonates with respiratory viruses such as severe acute respiratory syndrome coronavirus 2 (SARS?CoV?2) infection may pose a risk to healthcare workers.... Read More about Airflow dispersion during common neonatal resuscitation procedures: A simulation study.
Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study (2021)
Journal Article
Shipley, L., Gale, C., & Sharkey, D. (2021). Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study. Archives of Disease in Childhood. Fetal and Neonatal Edition, 106(5), https://doi.org/10.1136/archdischild-2020-320902Objective: Hypoxic-ischaemic encephalopathy (HIE) remains a leading cause of neonatal mortality and neurodisability. We aimed to determine the incidence of HIE and management patterns against national guidelines. Design: Retrospective cohort study... Read More about Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study.
Smartphone monitoring of in-ambulance vibration and noise (2021)
Journal Article
Partridge, T., Gherman, L., Morris, D., Light, R., Leslie, A., Sharkey, D., …Crowe, J. (2021). Smartphone monitoring of in-ambulance vibration and noise. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 235(4), 428-436. https://doi.org/10.1177/0954411920985994Transferring sick premature infants between hospitals increases the risk of severe brain injury, potentially linked to the excessive exposure to noise, vibration and driving-related accelerations. One method of reducing these levels may be to travel... Read More about Smartphone monitoring of in-ambulance vibration and noise.
Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance (2020)
Journal Article
Gale, C., Quigley, M. A., Placzek, A., Knight, M., Ladhani, S., Draper, E. S., …Kurinczuk, J. J. (2021). Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. Lancet Child and Adolescent Health, 5(2), 113-121. https://doi.org/10.1016/S2352-4642%2820%2930342-4Background: Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aime... Read More about Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.
Early childhood respiratory morbidity and antibiotic use in ex-preterm infants: A primary care population-based cohort study (2020)
Journal Article
Tan, S., Szatkowski, L., Moreton, W., Fiaschi, L., McKeever, T., Gibson, J., & Sharkey, D. (2020). Early childhood respiratory morbidity and antibiotic use in ex-preterm infants: A primary care population-based cohort study. European Respiratory Journal, 56(1), https://doi.org/10.1183/13993003.00202-2020Background Globally, bronchopulmonary dysplasia (BPD) continues to increase in preterm infants. Recent studies exploring subsequent early childhood respiratory morbidity have been small or focused on hospital admissions. Primary aim Examine early... Read More about Early childhood respiratory morbidity and antibiotic use in ex-preterm infants: A primary care population-based cohort study.
Accurate neonatal heart rate monitoring using a new wireless, cap mounted device (2020)
Journal Article
Henry, C., Shipley, L., Ward, C., Mirahmadi, S., Liu, C., Morgan, S., …Sharkey, D. (2020). Accurate neonatal heart rate monitoring using a new wireless, cap mounted device. Acta Paediatrica, 110(1), 72-78. https://doi.org/10.1111/apa.15303© 2020 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica Aim: A device for newborn heart rate (HR) monitoring at birth that is compatible with delayed cord clamping and minimises hypothermia r... Read More about Accurate neonatal heart rate monitoring using a new wireless, cap mounted device.
Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups (2020)
Journal Article
Taylor, C., Tan, S., McClaughry, R., & Sharkey, D. (2020). Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups. Neonatology, 117(4), 513–516. https://doi.org/10.1159/000506427Background: Hospital-acquired viral respiratory tract infections (VRTIs) cause significant morbidity and mortality in neonatal patients. This includes escalation of respiratory support, increased length of hospital stay, and need for home oxygen, as... Read More about Hospital-Acquired Viral Respiratory Tract Infections in the Neonatal Unit: A Comparison with Other Inpatient Groups.
Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements (2019)
Journal Article
Pickup, L., Lang, A., Shipley, L., Henry, C., Carpenter, J., McCartney, D., …Sharkey, D. (2019). Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements. JMIR Human Factors, 6(2), Article e12055. https://doi.org/10.2196/12055Background: A novel medical device has been developed to address an unmet need of standardizing and facilitating heart rate recording during neonatal resuscitation. In a time-critical emergency resuscitation, where failure can mean death of an infant... Read More about Development of a Clinical Interface for a Novel Newborn Resuscitation Device: Human Factors Approach to Understanding Cognitive User Requirements.
Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age (2019)
Journal Article
Shipley, L. J., Gyorkos, T., Jon, D., Tata, L. J., Lisa, S., & Sharkey, D. (2019). Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age. Pediatric Critical Care Medicine, 20(7), 638-644. https://doi.org/10.1097/PCC.0000000000001937Objectives: Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. Design: Retrospective cohort study. Setting: Tertiary neonatal centers of the Trent Per... Read More about Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age.
Postnatal gestational age estimation of newborns using Small Sample Deep Learning (2018)
Journal Article
Torres Torres, M., Valstar, M., Henry, C., Ward, C., & Sharkey, D. (2019). Postnatal gestational age estimation of newborns using Small Sample Deep Learning. Image and Vision Computing, 83-84, 87-99. https://doi.org/10.1016/j.imavis.2018.09.003© 2018 A baby's gestational age determines whether or not they are premature, which helps clinicians decide on suitable post-natal treatment. The most accurate dating methods use Ultrasound Scan (USS) machines, but these are expensive, require traine... Read More about Postnatal gestational age estimation of newborns using Small Sample Deep Learning.
Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates (2018)
Journal Article
Szatkowski, L., McClaughry, R., Clarkson, M., & Sharkey, D. (2019). Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates. European Respiratory Journal, 53(3), Article 1801874. https://doi.org/10.1183/13993003.01874-2018Restricting visitors on the neonatal intensive care unit to parents only during a worldwide pandemic resulted in a 39% reduction in nosocomial viral respiratory tract infections in neonatal patients. These findings need validating in a prospective tr... Read More about Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates.
Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study (2018)
Journal Article
Bannister, J., Szatkowski, L., Sharkey, D., Tan, S., Fiaschi, L., & Ban, L. (2018). Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition, 67(5), 580–585. https://doi.org/10.1097/MPG.0000000000002045Objectives: Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesised link between the gastrointestinal (GI) tract and immune function, this study explores rates of... Read More about Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study.
Variation in visiting and isolation policies in neonatal units: a UK nationwide survey (2017)
Journal Article
Tan, S., Clarkson, M., & Sharkey, D. (in press). Variation in visiting and isolation policies in neonatal units: a UK nationwide survey. Pediatric Infectious Disease Journal, https://doi.org/10.1097/INF.0000000000001820Global pandemics, such as H1N1, are a major risk for neonatal patients. We surveyed UK tertiary and district neonatal units about visiting and infection control policies relating to viral respiratory infections. There was marked variation with visiti... Read More about Variation in visiting and isolation policies in neonatal units: a UK nationwide survey.
Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo (2017)
Journal Article
Scotney, H., Symonds, M. E., Law, J., Budge, H., Sharkey, D., & Manolopoulos, K. N. (2017). Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo. Metabolism, 70, 125-132. https://doi.org/10.1016/j.metabol.2017.01.024© 2017 The Authors Introduction Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adre... Read More about Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo.
Neonatal head and torso vibration exposure during inter-hospital transfer (2017)
Journal Article
Blaxter, L., Yeo, M., McNally, D., Crowe, J., Henry, C., Hill, S., …Sharkey, D. (2017). Neonatal head and torso vibration exposure during inter-hospital transfer. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 231(2), 99-113. https://doi.org/10.1177/0954411916680235© Institution of Mechanical Engineers. Inter-hospital transport of premature infants is increasingly common, given the centralisation of neonatal intensive care. However, it is known to be associated with anomalously increased morbidity, most notably... Read More about Neonatal head and torso vibration exposure during inter-hospital transfer.
Outcomes of nosocomial viral respiratory infections in high-risk neonates (2016)
Journal Article
Zinna, S., Lakshmanan, A., Tan, S., McClaughry, R., Clarkson, M., Soo, S., …Sharkey, D. (2016). Outcomes of nosocomial viral respiratory infections in high-risk neonates. Pediatrics, 138(5), Article e20161675. https://doi.org/10.1542/peds.2016-1675BACKGROUND AND OBJECTIVE: Neonatal respiratory disease, particularly bronchopulmonary dysplasia, remains one of the leading causes of morbidity and mortality in newborn infants. Recent evidence suggests nosocomially acquired viral respiratory tract... Read More about Outcomes of nosocomial viral respiratory infections in high-risk neonates.
An automated quasi-continuous capillary refill timing device (2015)
Journal Article
Blaxter, L., Morris, D. E., Crowe, J. A., Henry, C., Hill, S. J., Sharkey, D., …Hayes-Gill, B. R. (in press). An automated quasi-continuous capillary refill timing device. Physiological Measurement, 37(1), https://doi.org/10.1088/0967-3334/37/1/83Capillary refill time (CRT) is a simple means of cardiovascular assessment which is widely used in clinical care. Currently, CRT is measured through manual assessment of the time taken for skin tone to return to normal colour following blanching of t... Read More about An automated quasi-continuous capillary refill timing device.
Forehead reflectance photoplethysmography to monitor heart rate: preliminary results from neonatal patients (2014)
Journal Article
Grubb, M., Carpenter, J., Crowe, J. A., Teoh, J., Marlow, N., Ward, C., …Hayes-Gill, B. R. (2014). Forehead reflectance photoplethysmography to monitor heart rate: preliminary results from neonatal patients. Physiological Measurement, 35(5), https://doi.org/10.1088/0967-3334/35/5/881Around 5%–10% of newborn babies require some form of resuscitation at birth and heart rate (HR) is the best guide of efficacy. We report the development and first trial of a device that continuously monitors neonatal HR, with a view to deployment in... Read More about Forehead reflectance photoplethysmography to monitor heart rate: preliminary results from neonatal patients.
Marked variation in newborn resuscitation practice: a national survey in the UK (2012)
Journal Article
Mann, C., Ward, C., Grubb, M., Hayes-Gill, B., Crowe, J., Marlow, N., & Sharkey, D. (2012). Marked variation in newborn resuscitation practice: a national survey in the UK. Resuscitation, 83(5), https://doi.org/10.1016/j.resuscitation.2012.01.002Abstract Background Although international newborn resuscitation guidance has been in force for some time, there are no UK data on current newborn resuscitation practices. Objective Establish delivery room (DR) resuscitation practices in the UK... Read More about Marked variation in newborn resuscitation practice: a national survey in the UK.