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All Outputs (51)

Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation (2021)
Journal Article
Bailey, J. A., Weller, J., Chapman, C., Ford, A., Hardy, K., Oliver, S., …Banerjea, A. (2021). Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation. BJS Open, 5(2), Article zraa056. https://doi.org/10.1093/bjsopen/zraa056

Background A novel pathway incorporating faecal immunochemical testing (FIT) for rapid colorectal cancer diagnosis (RCCD) was introduced in 2017. This paper reports on the service evaluation after 2 years of pathway implementation. Methods The R... Read More about Faecal immunochemical testing and blood tests for prioritization of urgent colorectal cancer referrals in symptomatic patients: a 2-year evaluation.

Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study (2021)
Journal Article
Adiamah, A., Ban, L., Otete, H., Crooks, C. J., West, J., & Humes, D. J. (2021). Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study. BJS Open, 5(2), https://doi.org/10.1093/bjsopen/zraa073

BACKGROUND: The management of perforated diverticular disease has changed in the past 10 years with a move towards less surgical intervention. This population-based cohort study aimed to define the risk of death and readmission following non-operativ... Read More about Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study.

Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer (2020)
Journal Article
Chapman, C. J., Banerjea, A., Humes, D. J., Allen, J., Oliver, S., Ford, A., …Morling, J. R. (2021). Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer. Clinical Chemistry and Laboratory Medicine, 59(4), 721-728. https://doi.org/10.1515/cclm-2020-1170

Objectives: Currently NICE recommends the use of faecal immunochemical test (FIT) at faecal haemoglobin concentrations (f-Hb) of 10 μg Hb/g faeces to stratify for colorectal cancer (CRC) risk in symptomatic populations. This f-Hb cut-off is advised a... Read More about Choice of faecal immunochemical test matters: comparison of OC-Sensor and HM-JACKarc, in the assessment of patients at high risk of colorectal cancer.

Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis (2020)
Journal Article
Hope, C., Reilly, J., Griffiths, G., Lund, J., & Humes, D. (2021). Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis. World Journal of Surgery, 45, 429-442

Background Attrition within surgical training is a challenge. In the USA, attrition rates are as high as 20-26%. The factors predicting attrition are not well known. The aim of this systematic review is to identify factors that influence attrition or... Read More about Factors Associated with Attrition and Performance Throughout Surgical Training: A Systematic Review and Meta-Analysis.

Mortality after extrahepatic gastrointestinal and abdominal wall surgery in patients with alcoholic liver disease: A systematic review and meta-analysis (2020)
Journal Article
Adiamah, A., Ban, L., Hammond, J., Jepsen, P., West, J., & Humes, D. .. (2020). Mortality after extrahepatic gastrointestinal and abdominal wall surgery in patients with alcoholic liver disease: A systematic review and meta-analysis. Alcohol and Alcoholism, 55(5), 497–511. https://doi.org/10.1093/alcalc/agaa043

Aims: This meta-analysis aimed to define the perioperative risk of mortality in patients with alcoholic liver disease (ALD) undergoing extrahepatic gastrointestinal surgery. Methods: Systematic searches of Embase, Medline and CENTRAL were undertak... Read More about Mortality after extrahepatic gastrointestinal and abdominal wall surgery in patients with alcoholic liver disease: A systematic review and meta-analysis.

GP access to FIT increases the proportion of colorectal cancers detected on urgent pathways in symptomatic patients in Nottingham (2020)
Journal Article
Bailey, J., Khawaja, A., Andrews, H., Weller, J., Chapman, C., Morling, J., …Banerjea, A. (2021). GP access to FIT increases the proportion of colorectal cancers detected on urgent pathways in symptomatic patients in Nottingham. Surgeon, 19(2), 93-102. https://doi.org/10.1016/j.surge.2020.03.002

Objective Service evaluation of GP access to Faecal Immunochemical Test (FIT) for colorectal cancer (CRC) detection in Nottinghamshire and use of FIT for “rule out”, “rule in” and “first test selection”. Design Retrospective audit of FIT results... Read More about GP access to FIT increases the proportion of colorectal cancers detected on urgent pathways in symptomatic patients in Nottingham.

Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults (2019)
Journal Article
El-Sharkawy, A. M., Devonald, M. A. J., Humes, D. J., Sahota, O., & Lobo, D. N. (2020). Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults. Clinical Nutrition, 39(8), P2593-2599. https://doi.org/10.1016/j.clnu.2019.11.030

© 2019 The Author(s) Background & aims: Hospitalised older adults are vulnerable to dehydration. However, the prevalence of hyperosmolar dehydration (HD) and its impact on outcome is unknown. Serum osmolality is not measured routinely but osmolarity,... Read More about Hyperosmolar dehydration: a predictor of kidney injury and outcome in hospitalised older adults.

A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis (2019)
Journal Article
Murray, K., Hoad, C., Garratt, J., Kaviani, M., Marciani, L., Smith, J., …Spiller, R. (2019). A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis. PLoS ONE, 14(5), Article e0216528. https://doi.org/10.1371/journal.pone.0216528

Background Complications of diverticular disease are increasingly common, possibly linked to increasing obesity. Visceral fat could contribute to the development of symptomatic diverticular disease through its pro-inflammatory effects. Objective... Read More about A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis.

Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study (2019)
Journal Article
Henry, M., Abdul-Sultan, A., Walker, A., West, J., & Humes, D. (2019). Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study. Digestive Surgery, 37(1), 32-38. https://doi.org/10.1159/000496435

Background: This study aimed to identify burden and risk of VTE associated with cholecystectomy in England. Methods: An historical cohort study of cholecystectomy patients from 2001-2011 was undertaken using linked primary (Clinical Practice... Read More about Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study.

A systematic review of population-based studies examining outcomes in primary retroperitoneal sarcoma surgery (2019)
Journal Article
Peacock, O., Patel, S., Simpson, J. A., Walter, C. J., & Humes, D. J. (2019). A systematic review of population-based studies examining outcomes in primary retroperitoneal sarcoma surgery. Surgical Oncology, 29, 53-63. https://doi.org/10.1016/j.suronc.2019.03.002

Retroperitoneal sarcomas (RPS) are rare mesenchymal tumours. Their rarity challenges our ability to understand expected outcomes. The aim of this systematic review was to examine 30-day morbidity and mortality, overall survival rates and prognostic p... Read More about A systematic review of population-based studies examining outcomes in primary retroperitoneal sarcoma surgery.

A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer (2019)
Journal Article
Chapman, C., Bunce, J., Oliver, S., Ng, O., Tangri, A., Rogers, R., …Banerjea, A. (2019). A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer. BJS Open, 3(3), 395-402. https://doi.org/10.1002/bjs5.50131

Introduction: New national guidance on urgent referral for investigation for Colorectal Cancer (CRC) included faecal occult blood testing in 2015. We evaluated faecal immunochemical testing (FIT) and anaemia as risk stratification tools in symptomati... Read More about A service evaluation of FIT and anaemia for risk stratification in the two week wait pathway for colorectal cancer.

Changing autonomy in operative experience through UK general surgery training: a national cohort study (2018)
Journal Article
Elsey, E. J., Griffiths, G., West, J., & Humes, D. J. (2019). Changing autonomy in operative experience through UK general surgery training: a national cohort study. Annals of Surgery, 269(3), 399-406. https://doi.org/10.1097/sla.0000000000003032

Objectives:To determine the operative experience of UK general surgery trainees and assess the changing procedural supervision and acquisition of competency assessments through the course of training. Background Summary Data: Competency assessment... Read More about Changing autonomy in operative experience through UK general surgery training: a national cohort study.

Time out of general surgery specialty training in the UK: a national database study (2018)
Journal Article
Elsey, E. J., West, J., Griffiths, G., & Humes, D. J. (2019). Time out of general surgery specialty training in the UK: a national database study. Journal of Surgical Education, 76(1), 55-64. https://doi.org/10.1016/j.jsurg.2018.06.011

Objective General surgery specialty training in the United Kingdom takes 6 years and allows trainees to take time out of training. Studies from the United States have highlighted an increasing trend for taking time out of surgical training for res... Read More about Time out of general surgery specialty training in the UK: a national database study.

Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study (2018)
Journal Article
Humes, D., Abdul-Sultan, A., Walker, A. J., Ludvigsson, J. F., & West, J. (in press). Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study. Hernia, https://doi.org/10.1007/s10029-017-1716-6

Purpose Little is known regarding the magnitude and timing of the risk of VTE following inguinal hernia surgery. We aimed to determine the absolute and relative rates of venous thromboembolism (VTE) following planned inguinal hernia repair. Methods... Read More about Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study.

Meta-analysis of operative experiences of general surgery trainees during training (2016)
Journal Article
Elsey, E., Griffiths, G., Humes, D., & West, J. (in press). Meta-analysis of operative experiences of general surgery trainees during training. British Journal of Surgery, 104(1), https://doi.org/10.1002/bjs.10396

BACKGROUND: General surgical training curricula around the world set defined operative numbers to be achieved before completion of training. However, there are few studies reporting total operative experience in training. This systematic review aimed... Read More about Meta-analysis of operative experiences of general surgery trainees during training.

Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England (2016)
Journal Article
Abdul Sultan, A., West, J., Ban, L., Humes, D., Tata, L. J., Fleming, K. M., …Card, T. R. (2016). Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England. Inflammatory Bowel Diseases, 22(7), 1621-1630. https://doi.org/10.1097/MIB.0000000000000802

Background: There is limited contemporary population based evidence on adverse birth outcomes and pregnancy related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variatio... Read More about Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England.