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The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis (2017)
Journal Article
Morandi, E., Tanasescu, R., Tarlinton, R. E., Constantinescu, C. S., Zhang, W., Tench, C. R., & Gran, B. (2017). The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis. PLoS ONE, 12(2), Article e0172415. https://doi.org/10.1371/journal.pone.0172415

Background: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.... Read More about The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis.

Decreased interferon-? induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis (2016)
Journal Article
Tanasescu, R., Midgley, A., Robins, R. A., & Constantinescu, C. S. (in press). Decreased interferon-? induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis. Acta Neurologica Scandinavica, https://doi.org/10.1111/ane.12715

Objectives. Interferon-? (IFN-?) is used in the treatment of multiple sclerosis (MS). IFN-? activation of signal transduction and activation of transcription (STAT)-4 is linked to its immunomodulatory effects. Previous studies suggest a type I IFN de... Read More about Decreased interferon-? induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis.

The future of multiple sclerosis treatments (2016)
Journal Article
Coclitu, C., Constantinescu, C. S., & Tanasescu, R. (in press). The future of multiple sclerosis treatments. Expert Review of Neurotherapeutics, 16(12), https://doi.org/10.1080/14737175.2016.1243056

Introduction. There are not many conditions in which the last few decades have brought such a major change in the landscape of treatments as is the case of multiple sclerosis (MS). A number of disease modifying treatments (DMTs) are presently availab... Read More about The future of multiple sclerosis treatments.

Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom (2016)
Journal Article
María Rodríguez Cruz, P., Matthews, L., Boggild, M., Cavey, A., Constantinescu, C. S., Evangelou, N., …Palace, J. (2016). Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom. JAMA Neurology, 73(8), 954-960. https://doi.org/10.1001/jamaneurol.2016.1463

Importance: The reports of seasonal variation in the births of people who later develop multiple sclerosis (MS) have been challenged and attributed to the background pattern in the general population, resulting in a false association. Objective:... Read More about Time- and Region-Specific Season of Birth Effects in Multiple Sclerosis in the United Kingdom.

Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices (2016)
Journal Article
Chou, I., Wang, H., Whitehouse, W. P., & Constantinescu, C. S. (in press). Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices. Current Neurology and Neuroscience Reports, 16(7), https://doi.org/10.1007/s11910-016-0663-4

Pediatric multiple sclerosis (MS) represents less than 5% of the MS population, but patients with pediatric-onset disease reach permanent disability at a younger age than adult onset patients. Accurate diagnosis at presentation and optimal long-term... Read More about Pediatric multiple sclerosis: update on diagnostic criteria, imaging, histopathology and treatment choices.

A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field (2016)
Journal Article
Cronin, M. J., Wharton, S., Al-Radaideh, A., Constantinescu, C., Evangelou, N., Bowtell, R. W., & Gowland, P. A. (2016). A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field. Magnetic Resonance Materials in Physics, Biology and Medicine, 29(3), 543-557. https://doi.org/10.1007/s10334-016-0560-5

Objective The aim of this study was to compare the use of high-resolution phase and QSM images acquired at ultra-high field in the investigation of multiple sclerosis (MS) lesions with peripheral rings, and to discuss their usefulness for drawing... Read More about A comparison of phase imaging and quantitative susceptibility mapping in the imaging of multiple sclerosis lesions at ultrahigh field.

Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis (2016)
Journal Article
Traboulsee, A. L., Cornelisse, P., Sandberg-Wollheim, M., Uitdehaag, B. M., Kappos, L., Jongen, P. J., …Li, D. K. (2016). Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis. Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2, https://doi.org/10.1177/2055217316666406

Objective: The objective of this article is to investigate potential clinical and MRI predictors of long-term outcomes in multiple sclerosis (MS). Methods: This was a post hoc analysis using data from all 382 patients in the PRISMS long-term foll... Read More about Prognostic factors for long-term outcomes in relapsing–remitting multiple sclerosis.

Cognitive Rehabilitation for Attention and Memory in people with Multiple Sclerosis: study protocol for a randomised controlled trial (CRAMMS) (2015)
Journal Article
Lincoln, N. B., das Nair, R., Bradshaw, L., Constantinescu, C. S., Drummond, A. E. R., Erven, A., …Morgan, M. (2015). Cognitive Rehabilitation for Attention and Memory in people with Multiple Sclerosis: study protocol for a randomised controlled trial (CRAMMS). Trials, 16(1), Article 556. https://doi.org/10.1186/s13063-015-1016-3

Background People with multiple sclerosis have problems with memory and attention. Cognitive rehabilitation is a structured set of therapeutic activities designed to retrain an individual’s memory and other cognitive functions. Cognitive rehabili... Read More about Cognitive Rehabilitation for Attention and Memory in people with Multiple Sclerosis: study protocol for a randomised controlled trial (CRAMMS).

Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and ?(9)-tetrahydrocannabinol in rat plasma (2015)
Journal Article
Zgair, A., Wong, J., Sabri, A., Fischer, P., Barrett, D., Constantinescu, C., & Gershkovich, P. (2015). Development of a simple and sensitive HPLC-UV method for the simultaneous determination of cannabidiol and ?(9)-tetrahydrocannabinol in rat plasma. Journal of Pharmaceutical and Biomedical Analysis, 114, 145-151. doi:10.1016/j.jpba.2015.05.019

Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study (2015)
Journal Article
Manouchehrinia, A., Edwards, L. J., Roshanisefat, H., Tench, C. R., & Constantinescu, C. S. (2015). Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study. BMJ Open, 5(5), 1-7. https://doi.org/10.1136/bmjopen-2015-007806

Objective: To determine if comorbid asthma is associated with accumulation of multiple sclerosis (MS)-related impairment and disability. Method: We sent a comprehensive questionnaire to a cohort of patients with MS and examined the association bet... Read More about Multiple sclerosis course and clinical outcomes in patients with comorbid asthma: a survey study.

Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis (2015)
Journal Article
Cook, K. W., Crooks, J., Hussain, K., O'Brien, K., Braitch, M., Kareem, H., …Gran, B. (2015). Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis. Frontiers in Microbiology, 6, Article 52. https://doi.org/10.3389/fmicb.2015.00052

Recent research has demonstrated that infection with the bacterial pathogen Helicobacter pylori is less common amongst patients with multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS). We aimed to compa... Read More about Helicobacter pylori infection reduces disease severity in an experimental model of multiple sclerosis.

Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis (2014)
Journal Article
Welton, T., Kent, D., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2015). Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis. Radiology, 275(1), 89-96. https://doi.org/10.1148/radiol.14140925

Purpose To identify statistical consensus between published studies for distribution and functional relevance of tract white matter (WM) degradation in multiple sclerosis (MS). Materials and Methods By systematically searching online databases... Read More about Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis.

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells (2014)
Journal Article
Hartmann, F. J., Khademi, M., Aram, J., Ammann, S., Kockum, I., Constantinescu, C., …Becher, B. (2014). Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells. Nature Communications, 5, Article 5056. https://doi.org/10.1038/ncomms6056

© 2014 Macmillan Publishers Limited. All rights reserved. Genome-wide association studies implicate dysregulation of immune mechanisms in the pathogenesis of multiple sclerosis (MS). Particularly, polymorphisms in genes involved in T helper (TH) cell... Read More about Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells.

Role of oral teriflunomide in the management of multiple sclerosis (2013)
Journal Article
Tanasescu, R., Evangelou, N., & Constantinescu, C. S. (2013). Role of oral teriflunomide in the management of multiple sclerosis. Neuropsychiatric Disease and Treatment, 9, https://doi.org/10.2147/NDT.S31248

The landscape of the treatment of relapsing–remitting multiple sclerosis is changing fast. Several oral treatments have shown benefit and generate much interest because of the convenience of their administration. Two oral compounds, fingolimod and te... Read More about Role of oral teriflunomide in the management of multiple sclerosis.