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The burden of chronic respiratory diseases in adults in Nepal: A systematic review (2021)
Journal Article
Ekezie, W., Jenkins, A. R., Hall, I. P., Evans, C., Koju, R., Kurmi, O. P., & Bolton, C. E. (2021). The burden of chronic respiratory diseases in adults in Nepal: A systematic review. Chronic Respiratory Disease, 18, 1-20. https://doi.org/10.1177/1479973121994572

While chronic lung disease causes substantial global morbidity and mortality, global estimates have primarily been based on broad assumptions. Specific country data from low-income countries such as Nepal are limited. This review assessed primary evi... Read More about The burden of chronic respiratory diseases in adults in Nepal: A systematic review.

Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study (2020)
Journal Article
Fermont, J. M., Fisk, M., Bolton, C. E., MacNee, W., Cockcroft, J. R., Fuld, J., …Wilkinson, I. B. (2020). Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study. BMJ Open, 10(12), Article e038360. https://doi.org/10.1136/bmjopen-2020-038360

Objectives Although cardiovascular disease (CVD) is a common comorbidity associated with chronic obstructive pulmonary disease (COPD), it is unknown how to improve prediction of cardiovascular (CV) risk in individuals with COPD. Traditional CV risk s... Read More about Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study.

Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study (2020)
Journal Article
Siraj, R., McKeever, T., Gibson, J., Gordon, A., & Bolton, C. (2021). Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study. Respiratory Medicine, 177, Article 106288. https://doi.org/10.1016/j.rmed.2020.106288

Background: Although cognitive impairment and dementia are common comorbidities in patients with chronic obstructive pulmonary disease (COPD), estimates of incidence following a diagnosis of COPD are inconclusive. Objective: To determine the incidenc... Read More about Risk of incident dementia and cognitive impairment in patients with chronic obstructive pulmonary disease (COPD): A large UK population-based study.

British Thoracic Society survey of rehabilitation to support recovery of the post-COVID- 19 population (2020)
Journal Article
Singh, S. J., Barradell, A. C., Greening, N. J., Bolton, C., Jenkins, G., Preston, L., & Hurst, J. R. (2020). British Thoracic Society survey of rehabilitation to support recovery of the post-COVID- 19 population. BMJ Open, 10(12), Article e040213. https://doi.org/10.1136/bmjopen-2020-040213

Objective A proportion of those recovering from COVID-19 are likely to have significant and ongoing symptoms, functional impairment and psychological disturbances. There is an immediate need to develop a safe and efficient discharge process and recov... Read More about British Thoracic Society survey of rehabilitation to support recovery of the post-COVID- 19 population.

Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease (2020)
Journal Article
Fermont, J. M., Mohan, D., Fisk, M., Bolton, C. E., Macnee, W., Cockcroft, J. R., …Polkey, M. I. (2021). Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease. Age and Ageing, 50(3), 795-801. https://doi.org/10.1093/ageing/afaa138

RATIONALE: chronic obstructive pulmonary disease (COPD) is a leading cause of mortality and common in older adults. The BODE Index is the most recognised mortality risk score in COPD but includes a 6-minute walk test (6MWT) that is seldom available i... Read More about Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease.

Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses (2020)
Journal Article
Ward, T. J. C., Lindley, M. R., Ferguson, R. A., Constantin, D., Singh, S. J., Bolton, C. E., …Steiner, M. C. (2021). Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses. Chest, 159(2), 564-574. https://doi.org/10.1016/j.chest.2020.08.2082

© 2020 American College of Chest Physicians Background: Eccentric cycling (ECC) may be an attractive exercise method in COPD because of both low cardiorespiratory demand and perception of effort compared with conventional concentric cycling (CON) at... Read More about Submaximal Eccentric Cycling in People With COPD: Acute Whole-Body Cardiopulmonary and Muscle Metabolic Responses.

Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study (2020)
Journal Article
Safavi, S., Arthofer, C., Cooper, A., Harkin, J. W., Prayle, A. P., Sovani, M. P., …Hall, I. P. (2020). Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study. European Journal of Radiology, 130, Article 109196. https://doi.org/10.1016/j.ejrad.2020.109196

Purpose The diaphragm is the most important muscle of respiration. Disorders of the diaphragm can have a deleterious impact on respiratory function. We aimed to evaluate the use of an open-configuration upright low-field MRI system to assess diaphra... Read More about Assessing the impact of posture on diaphragm morphology and function using an open upright MRI system – a pilot study.

Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative (2020)
Journal Article
Crossley, D., Stockley, J., Bolton, C. E., Hopkinson, N. S., Mahadeva, R., Steiner, M., …Stockley, R. A. (2020). Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative. BMJ Open, 10(6), Article e036045. https://doi.org/10.1136/bmjopen-2019-036045

Objectives To establish a database network for the study of alpha-1 antitrypsin deficiency (AATD) and compare the results to CT lung density as the most direct measure of emphysema. Design A central electronic database was established to permit th... Read More about Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative.

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement (2020)
Journal Article
Gupta, A., Jayes, L. R., Holmes, S., Sahota, O., Canavan, M., Elkin, S. L., …Bolton, C. E. (2020). Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement. International Journal of Chronic Obstructive Pulmonary Disease, 15, 1377-1390. https://doi.org/10.2147/copd.s233398

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patien... Read More about Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.

Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years (2020)
Journal Article
Hurst, J. R., Beckmann, J., Ni, Y., Bolton, C. E., McEniery, C. M., Cockcroft, J. R., & Marlow, N. (2020). Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years. American Journal of Respiratory and Critical Care Medicine, 202(3), 422-432. https://doi.org/10.1164/rccm.202001-0016oc

Rationale: Growth and development during adolescence may modify the respiratory and vascular differences seen among extremely preterm (EP) individuals in childhood and early adolescence. Objective: To assess the trajectory of respiratory and cardi... Read More about Respiratory and Cardiovascular Outcomes in Survivors of Extremely Preterm Birth at 19 Years.

Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study (2020)
Journal Article
Fermont, J. M., Bolton, C. E., Fisk, M., Mohan, D., Macnee, W., Cockcroft, J. R., …Müllerova, H. (2020). Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study. PLoS ONE, 15(2), e0228940. https://doi.org/10.1371/journal.pone.0228940

In chronic obstructive pulmonary disease (COPD), acute exacerbation of COPD requiring hospital admission is associated with mortality and healthcare costs. The ERICA study assessed multiple clinical measures in people with COPD, including the short... Read More about Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study.

Highlights 2019: fresh focus on health (2019)
Journal Article
Palmer, J., Bolton, C. E., Shrestha, P., Adhikari, P., & Karmacharya, B. (2019). Highlights 2019: fresh focus on health. Lancet, 394(10216), 2219-2236. https://doi.org/10.1016/s0140-6736%2819%2933060-0

Contribution towards Fresh focus on health: Highlights 2019 photography competition open for submissions. Palmer J. Lancet. 2019 Jun 8;393(10188):2284-2285. doi: 10.1016/S0140-6736(19)31258-9. Epub 2019 Jun 6 https://www.ncbi.nlm.nih.gov/pubm... Read More about Highlights 2019: fresh focus on health.

European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia (2019)
Journal Article
Duijts, L., van Meel, E. R., Moschino, L., Baraldi, E., Barnhoorn, M., Bramer, W. M., …Pijnenburg, M. W. (2020). European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia. European Respiratory Journal, 55(1), Article 1900788. https://doi.org/10.1183/13993003.00788-2019

This document provides recommendations for monitoring and treatment of children in whom bronchopulmonary dysplasia (BPD) has been established and were discharged from the hospital, or who were older than 36 weeks of postmenstrual age. The guideline w... Read More about European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia.

Building toolkits for COPD exacerbations: lessons from the past and present (2019)
Journal Article
Sapey, E., Bafadhel, M., Bolton, C. E., Wilkinson, T., Hurst, J. R., & Quint, J. K. (2019). Building toolkits for COPD exacerbations: lessons from the past and present. Thorax, 74(9), 898-905. https://doi.org/10.1136/thoraxjnl-2018-213035

In the nineteenth century, it was recognised that acute attacks of chronic bronchitis were harmful. 140 years later, it is clearer than ever that exacerbations of chronic obstructive pulmonary disease (ECOPD) are important events. They are associated... Read More about Building toolkits for COPD exacerbations: lessons from the past and present.

A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency (2019)
Journal Article
Newby, P. R., Crossley, D., Crisford, H., Stockley, J. A., Mumford, R. A., Carter, R. I., …Stockley, R. A. (2019). A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency. ERJ Open Research, 5(3), Article 00095-2019. https://doi.org/10.1183/23120541.00095-2019

Alpha-1-antitrypsin deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase has long been considered the enzyme responsible. However, proteinase 3 also produces the pathological features of Chronic Obst... Read More about A Specific Proteinase 3 Activity Footprint in Alpha-1-antitrypsin Deficiency.

Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review (2019)
Journal Article
Pick, H. J., Bolton, C. E., Lim, W. S., & McKeever, T. M. (2019). Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review. European Respiratory Journal, 53(3), https://doi.org/10.1183/13993003.02165-2018

Symptomatic and functional recovery are important patient-reported outcome measures (PROMs) in community-acquired pneumonia (CAP) that are increasingly used as trial endpoints. This systematic review summarises the literature on PROMs in CAP. Comp... Read More about Patient reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review.

Hip fracture outcomes in patients with COPD (2018)
Journal Article
Buss, L., McKeever, T. M., Nightingale, J., Akyea, R., Ollivere, B., Moppett, I., & Bolton, C. E. (2018). Hip fracture outcomes in patients with COPD. British Journal of Anaesthesia, 121(6), 1377-1379. https://doi.org/10.1016/j.bja.2018.09.008+hideArticle+Info

Hip fractures are common in patients with COPD and contemporary outcome data is needed. Patients admitted with a hip fracture to one acute trust (2010-2015) were assessed prospectively (UK National Hip Fracture Database audit) and mortality data col... Read More about Hip fracture outcomes in patients with COPD.