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Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study (2022)
Journal Article
Piernas, C., Patone, M., Astbury, N. M., Gao, M., Sheikh, A., Khunti, K., …Jebb, S. A. (2022). Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study. Lancet Diabetes and Endocrinology, 10(8), 571-580. https://doi.org/10.1016/s2213-8587%2822%2900158-9

Background: A high BMI has been associated with a reduced immune response to vaccination against influenza. We aimed to investigate the association between BMI and COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes a... Read More about Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study.

Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study (2022)
Journal Article
Tan, P. S., Garriga, C., Clift, A., Liao, W., Patone, M., Coupland, C., …Hippisley-Cox, J. (2023). Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study. Gut, 72(3), 512-521. https://doi.org/10.1136/gutjnl-2021-326522

Objective Prior studies identified clinical factors associated with increased risk of pancreatic ductal adenocarcinoma (PDAC). However, little is known regarding their time-varying nature, which could inform earlier diagnosis. This study assessed tem... Read More about Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case–control study.

Common protocol for validation of the QCOVID algorithm across the four UK nations (2022)
Journal Article
Kerr, S., Robertson, C., Nafilyan, V., Lyons, R. A., Kee, F., Cardwell, C. R., …Sheikh, A. (2022). Common protocol for validation of the QCOVID algorithm across the four UK nations. BMJ Open, 12(6), Article e050994. https://doi.org/10.1136/bmjopen-2021-050994

Introduction The QCOVID algorithm is a risk prediction tool for infection and subsequent hospitalisation/death due to SARS-CoV-2. At the time of writing, it is being used in important policy-making decisions by the UK and devolved governments for com... Read More about Common protocol for validation of the QCOVID algorithm across the four UK nations.

Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries (2022)
Journal Article
Swain, S., Kamps, A., Runhaar, J., Dell ‘Isola, A., Turkiewicz, A., Robinson, D., …Zhang, W. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries. BMJ Open, 12(4), Article e052816. https://doi.org/10.1136/bmjopen-2021-052816

Introduction: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case–control and cohort study using large electronic health records in four European countries.

The prevalence, incidence, prognosis and risk factors for symptoms of depression and anxiety in a UK cohort during the COVID-19 pandemic (2022)
Journal Article
Jia, R., Ayling, K., Chalder, T., Massey, A., Gasteiger, N., Broadbent, E., …Vedhara, K. (2022). The prevalence, incidence, prognosis and risk factors for symptoms of depression and anxiety in a UK cohort during the COVID-19 pandemic. BJPsych Open, 8(2), Article e64. https://doi.org/10.1192/bjo.2022.34

Background The COVID-19 pandemic has had profound consequences for population mental health. However, it is less clear for whom these effects are sustained. Aims To investigate the prevalence, incidence, prognosis and risk factors for symptoms of dep... Read More about The prevalence, incidence, prognosis and risk factors for symptoms of depression and anxiety in a UK cohort during the COVID-19 pandemic.

Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records. Evidence-Based Mental Health, 25(4), 169-176. https://doi.org/10.1136/ebmental-2021-300355

BACKGROUND: Studies report an increased risk of self-harm or suicide in people prescribed mirtazapine compared with other antidepressants. OBJECTIVES: To compare the risk of serious self-harm in people prescribed mirtazapine versus other antidepressa... Read More about Association between mirtazapine use and serious self-harm in people with depression: an active comparator cohort study using UK electronic health records.

Association between smoking, e-cigarette use and severe COVID-19: A cohort study (2022)
Journal Article
Gao, M., Aveyard, P., Lindson, N., Hartmann-Boyce, J., Watkinson, P., Young, D., …Hippisley-Cox, J. (2022). Association between smoking, e-cigarette use and severe COVID-19: A cohort study. International Journal of Epidemiology, 51(4), 1062-1072. https://doi.org/10.1093/ije/dyac028

Background: Smoking is a risk factor for most respiratory infections, but it may protect against SARS-CoV-2 infection. The objective was to assess whether smoking and e-cigarette use were associated with severe COVID-19. Methods: This cohort ran from... Read More about Association between smoking, e-cigarette use and severe COVID-19: A cohort study.

Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT) (2022)
Journal Article
Stevenson, D. J., Avery, A. J., Coupland, C., Hobbs, F. D. R., Kendrick, D., Moore, M. V., …Dumbleton, J. S. (2022). Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT). Trials, 23(1), Article 140. https://doi.org/10.1186/s13063-022-06054-w

Background: The Helicobacter Eradication Aspirin Trial (HEAT) is a multicentre, double blind, randomised controlled trial investigating whether Helicobacter (H.) pylori eradication reduces hospitalisation for peptic ulcer bleeding. Recruited particip... Read More about Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT).

‘It is designed for everybody to find their own level and to improve themselves’; views of older people and instructors of the Falls Management Exercise (FaME) programme (2022)
Journal Article
Gumber, L., Timmons, S., Coupland, C., Gladman, J., Lliffe, S., Kendrick, D., …Orton, E. (2022). ‘It is designed for everybody to find their own level and to improve themselves’; views of older people and instructors of the Falls Management Exercise (FaME) programme. Age and Ageing, 51(2), Article afac023. https://doi.org/10.1093/ageing/afac023

Background: Older adults are at increased risk of falls due to ageing, decreased muscle strength and impaired balance. Clinical trials have demonstrated the efficacy and effectiveness of the Falls Management Exercise (FaME) programme in improving fun... Read More about ‘It is designed for everybody to find their own level and to improve themselves’; views of older people and instructors of the Falls Management Exercise (FaME) programme.

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study (2022)
Journal Article
Swain, S., Coupland, C., Strauss, V., Mallen, C., Kuo, C. F., Sarmanova, A., …Zhang, W. (2022). Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study. Osteoarthritis and Cartilage, 30(5), 702-713. https://doi.org/10.1016/j.joca.2021.12.013

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with in... Read More about Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study.

The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records (2022)
Journal Article
Joseph, R. M., Jack, R. H., Morriss, R., Knaggs, R. D., Butler, D., Hollis, C., …Coupland, C. (2022). The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records. BMC Medicine, 20(1), Article 43. https://doi.org/10.1186/s12916-022-02247-x

Background Studies have reported an increased risk of mortality among people prescribed mirtazapine compared to other antidepressants. The study aimed to compare all-cause and cause-specific mortality between adults prescribed mirtazapine or other s... Read More about The risk of all-cause and cause-specific mortality in people prescribed mirtazapine: an active comparator cohort study using electronic health records.

Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets (2022)
Journal Article
Burchardt, J. M., Mei, X. W., Ranger, T., McDermott, C. J., Radunovic, A., Coupland, C., & Hippisley-Cox, J. (2022). Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 23(5-6), 363-371. https://doi.org/10.1080/21678421.2021.2016837

Objective: This study uses three linked datasets to provide an estimate of incidence of motor neuron disease (MND) in England from 1998 to 2019. Comparison is made to previous British studies. It examines age at diagnosis and ethnicity of those affec... Read More about Analysis of incidence of motor neuron disease in England 1998–2019: use of three linked datasets.

Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept (2022)
Journal Article
Vedhara, K., Ayling, K., Jia, R., Fairclough, L., Morling, J. R., Ball, J. K., …Tighe, P. (2022). Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept. Journal of Infectious Diseases, 225(12), 2137-2141. https://doi.org/10.1093/infdis/jiac006

Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed mea... Read More about Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept.

Psychological Predictors of Self-reported COVID-19 Outcomes: Results From a Prospective Cohort Study (2022)
Journal Article
Ayling, K., Jia, R., Coupland, C., Chalder, T., Massey, A., Broadbent, E., & Vedhara, K. (2022). Psychological Predictors of Self-reported COVID-19 Outcomes: Results From a Prospective Cohort Study. Annals of Behavioral Medicine, 56(5), 484-497. https://doi.org/10.1093/abm/kaab106

Background: Previous research has shown that psychological factors, such as stress and social support, are associated with greater susceptibility to viral respiratory illnesses and more severe symptoms. During the COVID-19 pandemic there has been a w... Read More about Psychological Predictors of Self-reported COVID-19 Outcomes: Results From a Prospective Cohort Study.

Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment (2022)
Journal Article
Abhishek, A., Fuller, A., Nakafero, G., Zhang, W., Dumbleton, J., Hawkey, C., …Doherty, M. (2022). Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment. Rheumatology Advances in Practice, 6(3), Article rkac086. https://doi.org/10.1093/rap/rkac086

Objective: The aim was to test the feasibility of a randomized controlled trial exploring whether omega-3 fatty acid supplementation limits gout flares during treat-to-target urate-lowering treatment (T2T-ULT). Methods: Adults with at least one gout... Read More about Feasibility of conducting a randomized, placebo-controlled study assessing whether omega-3 fatty acids prevent gout flares when starting urate-lowering treatment.

Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort (2022)
Journal Article
Swain, S., Fernandes, G. S., Sarmanova, A., Valdes, A. M., Walsh, D. A., Coupland, C., …Zhang, W. (2022). Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort. Rheumatology Advances in Practice, 6(2), Article rkac049. https://doi.org/10.1093/rap/rkac049

Objectives: The aims were to examine the prevalence of comorbidities and role of oral analgesic use in people with knee pain (KP) compared with those without. Methods: The Knee Pain and related health In the Community (KPIC) cohort comprises communit... Read More about Comorbidities and use of analgesics in people with knee pain: a study in the Nottingham Knee Pain and Health in the Community (KPIC) cohort.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection (2021)
Journal Article
Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., …Hippisley-Cox, J. (2022). Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection. Nature Medicine, 28(2), 410-422. https://doi.org/10.1038/s41591-021-01630-0

Although myocarditis and pericarditis were not observed as adverse events in coronavirus disease 2019 (COVID-19) vaccine trials, there have been numerous reports of suspected cases following vaccination in the general population. We undertook a self-... Read More about Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.

Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection (2021)
Journal Article
Patone, M., Handunnetthi, L., Saatci, D., Pan, J., Katikireddi, S. V., Razvi, S., …Hippisley-Cox, J. (2021). Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nature Medicine, 27(12), 2144-2153. https://doi.org/10.1038/s41591-021-01556-7

Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. We undertook a self-controlled case series study to investigate hospital admission... Read More about Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection.

Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases (2021)
Journal Article
Vinogradova, Y., Dening, T., Hippisley-Cox, J., Taylor, L., Moore, M., & Coupland, C. (2021). Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases. BMJ, 374, Article n2182. https://doi.org/10.1136/bmj.n2182

Objective To assess the risks of developing dementia associated with different types and durations of menopausal hormone therapy. Design Two nested case-control studies. Setting UK general practices contributing to QResearch or the Clinical Practice... Read More about Use of menopausal hormone therapy and risk of dementia: Nested case-control studies using QResearch and CPRD databases.

Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population (2021)
Journal Article
Liao, W., Clift, A. K., Patone, M., Coupland, C., González-Izquierdo, A., Pereira, S., & Cox, J. H. (2021). Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population. British Journal of General Practice, 71(712), e836-e845. https://doi.org/10.3399/bjgp.2021.0153

Background: Pancreatic cancer has the worst survival rate among all cancers. Almost 70% of patients were diagnosed at Stage IV. Aim: This study aimed to investigate the symptoms associated with the diagnoses of pancreatic ductal adenocarcinoma (P... Read More about Identifying symptoms associated with diagnosis of pancreatic exocrine and neuroendocrine neoplasms: A nested case-control study of the UK primary care population.