Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

Killick, R.; Ribe, E. M.; Al-Shawi, R.; Malik, B.; Hooper, C.; Fernandes, C.; Dobson, R.; Nolan, P. M.; LOURDUSAMY, AROCKIA; Furney, S.; Lin, K.; Breen, G.; Wroe, R.; To, A .W.M.; Leroy, K.; Causevic, M.; Usardi, A.; Robinson, M.; Noble, W.; Williamson, R.; Lunnon, K.; Kellie, S.; Reynolds, C. H.; Bazenet, C.; Hodges, A.; Brion, J-P; Stephenson, J.; Paul Simons, J.; Lovestone, Simon

doi:10.1038/mp.2012.163

All Outputs (23)

Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents (2014)
Journal Article
Desrivières, S., the IMAGEN Consortium, Lourdusamy, A., Tao, C., Toro, R., Jia, T., …Schumann, G. (2015). Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents. Molecular Psychiatry, 20(2), 263-274. https://doi.org/10.1038/mp.2013.197

Despite the recognition that cortical thickness is heritable and correlates with intellectual ability in children and adolescents, the genes contributing to individual differences in these traits remain unknown. We conducted a large-scale association... Read More about Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents.

Oxytocin Receptor Genotype Modulates Ventral Striatal Activity to Social Cues and Response to Stressful Life Events (2013)
Journal Article
Loth, E., Poline, J., Thyreau, B., Jia, T., Tao, C., Lourdusamy, A., …Schumann, G. (2014). Oxytocin Receptor Genotype Modulates Ventral Striatal Activity to Social Cues and Response to Stressful Life Events. Biological Psychiatry, 76(5), 367-376. https://doi.org/10.1016/j.biopsych.2013.07.043

Background Common variants in the oxytocin receptor gene (OXTR) have been shown to influence social and affective behavior and to moderate the effect of adverse experiences on risk for social-affective problems. However, the intermediate neurobiologi... Read More about Oxytocin Receptor Genotype Modulates Ventral Striatal Activity to Social Cues and Response to Stressful Life Events.

Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway (2012)
Journal Article
Killick, R., Ribe, E. M., Al-Shawi, R., Malik, B., Hooper, C., Fernandes, C., …Lovestone, S. (2014). Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular Psychiatry, 19(1), 88-98. https://doi.org/10.1038/mp.2012.163

Although the mechanism of Abaction in the pathogenesis of Alzheimer’s disease (AD) has remained elusive, it is known to increasethe expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing ofDkk1blocks Abneur... Read More about Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.