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Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells (2021)
Journal Article
Akhtar, R., Tahir, H., Stewart, E., Wei, R., Mohammed, I., & Amoaku, W. M. (2021). Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells. International Journal of Translational Medicine, 1(1), 25-38. https://doi.org/10.3390/ijtm1010003

Retinal diseases are the leading causes of irreversible blindness worldwide. The role of toll-like receptor (TLR) signalling mechanisms (MyD88 and TRIF) in the production of pro-angiogenic growth factors from human microvascular endothelial cells (HM... Read More about Toll-Like Receptor Signalling Pathways Regulate Hypoxic Stress Induced Fibroblast Growth Factor but Not Vascular Endothelial Growth Factor-A in Human Microvascular Endothelial Cells.

Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations (2020)
Journal Article
Zouache, M. A., Silvestri, G., Amoaku, W. M., Silvestri, V., Hubbard, W. C., Pappas, C., …Hageman, G. S. (2020). Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations. Translational Vision Science & Technology, 9(5), Article 24. https://doi.org/10.1167/tvst.9.5.24

Purpose: The purpose of this study was to characterize foveal pit morphology in an African (Ghanaian) population, to compare it to that of a Caucasian group and to determine if it varied with age in the two populations. Methods: The depth, diamet... Read More about Comparison of the Morphology of the Foveal Pit Between African and Caucasian Populations.

Natural course of adult-onset vitelliform lesions in eyes with and without comorbid subretinal drusenoid deposits (2020)
Journal Article
Yeung, A. M., Wilde, C., Awad, M., Giannouladis, K., Lakshmanan, A., Dua, H., & Amoaku, W. M. (2020). Natural course of adult-onset vitelliform lesions in eyes with and without comorbid subretinal drusenoid deposits. International Ophthalmology, 40, 1501–1508. https://doi.org/10.1007/s10792-020-01319-2

Purpose Adult vitelliform lesions (AVL) are associated with age related macular degeneration (AMD) and subretinal drusenoid deposits (SRDD). We evaluated the natural course of AVL, assessing the influence of SRDD on disease progression, visual fun... Read More about Natural course of adult-onset vitelliform lesions in eyes with and without comorbid subretinal drusenoid deposits.

Hypercapnia augments resistive exercise?induced elevations in intraocular pressure in older individuals (2020)
Journal Article
Mekjavic, I. B., Amoaku, W., Mlinar, T., & Mekjavic, P. J. (2020). Hypercapnia augments resistive exercise?induced elevations in intraocular pressure in older individuals. Experimental Physiology, 105(4), 641-651. https://doi.org/10.1113/ep088236

The present study assessed the effect of 6° head down (establishing the cephalad displacement noted in astronauts in microgravity) prone (simulating the effect on the eye) tilt during rest and exercise (simulating exercise performed by astronauts to... Read More about Hypercapnia augments resistive exercise?induced elevations in intraocular pressure in older individuals.

Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey (2019)
Journal Article
Parfitt, A., Boxell, E., Amoaku, W. M., & Bradley, C. (2019). Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey. BMJ Open Ophthalmology, 4(1), Article e000276. https://doi.org/10.1136/bmjophth-2019-000276

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objectives To investigate whether people with age-related macular degeneration (AMD) are able to self-detect... Read More about Patient-reported reasons for delay in diagnosis of age-related macular degeneration: a national survey.

Biofeedback fixation training method for improving eccentric vision in patients with loss of foveal function secondary to different maculopathies (2019)
Journal Article
Morales, M. U., Saker, S., Wilde, C., Rubinstein, M., Limoli, P., & Amoaku, W. M. (2020). Biofeedback fixation training method for improving eccentric vision in patients with loss of foveal function secondary to different maculopathies. International Ophthalmology, 40, 305–312. https://doi.org/10.1007/s10792-019-01180-y

© 2019, The Author(s). Purpose: Fixation stability (FS) of the preferred retinal locus (PRL) may be improved by biofeedback fixation training (BFT) with microperimetry. Such training can be done on the patient’s PRL or in different retinal loci with... Read More about Biofeedback fixation training method for improving eccentric vision in patients with loss of foveal function secondary to different maculopathies.

In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles (2019)
Journal Article
Al-Aqaba, M. A., Anis, F. S., Mohammed, I., Yapa, A. D. S., Amoaku, W. M., & Dua, H. S. S. (2019). In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles. British Journal of Ophthalmology, 1-5. https://doi.org/10.1136/bjophthalmol-2018-313199

Aims To describe the in vivo confocal microscopy (IVCM) features of human limbal nerve corpuscles (LNCs) and correlate these with the histological features. Methods We examined 40 eyes of 29 healthy living subjects (17 female, 12 male; mean age=47... Read More about In vivo confocal microscopy features and clinicohistological correlation of limbal nerve corpuscles.

Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique (2018)
Journal Article
Mehta, P., Al-Kinani, A. A., Qutachi, O., Arshad, M. S., Alqahtani, A., Chang, M., …Ahmad, Z. (2019). Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique. Journal of Physics: Materials, 2(1), 1-7. https://doi.org/10.1088/2515-7639/aaf263

In vitro testing alone is no longer considered sufficient evidence presented solely with respect to drug release and permeation testing. These studies are thought to be more reliable and representative when using tissue or animal models; as opposed t... Read More about Assessing the ex vivo permeation behaviour of functionalised contact lens coatings engineered using an electrohydrodynamic technique.

Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006) (2018)
Journal Article
Wilde, C., Poostchi, A., Narendran, R., MacNab, H. K., Hillman, J. G., Alexander, P., …Vernon, S. A. (2019). Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006). Eye, 33(4), 580-586. https://doi.org/10.1038/s41433-018-0263-4

Aims: To determine disc haemorrhages (DH) prevalence in an elderly UK population-the Bridlington Eye Assessment Project (BEAP). Methods: Thirty-degree (30°) fundus photographs (3549 participants ≥65 years) were graded for DH/macula changes. Glaucoma... Read More about Prevalence of optic disc haemorrhages in an elderly UK Caucasian population and possible association with reticular pseudodrusen—the Bridlington Eye Assessment Project (BEAP): a cross-sectional study (2002–2006).

Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006) (2018)
Journal Article
Wilde, C., Poostchi, A., Mehta, R. L., Hillman, J. G., MacNab, H. K., Messina, M., …Amoaku, W. M. (2019). Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006). Eye, 33(3), 451-458. https://doi.org/10.1038/s41433-018-0232-y

© 2018, The Royal College of Ophthalmologists. Purpose: There is paucity of data on the epidemiology of peripapillary choroidal neovascularisartion (PPCNV). Our aim was to determine prevalence of PPCNV in the elderly UK population of Bridlington res... Read More about Prevalence of peripapillary choroidal neovascular membranes (PPCNV) in an elderly UK population—the Bridlington eye assessment project (BEAP): a cross-sectional study (2002–2006).

Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study (2018)
Journal Article
Wilde, C., Awad, M., Dua, H., Gandhewar, R., Chen, H., & Amoaku, W. M. (2018). Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study. Ophthalmology Retina, 2(12), 1218-1226. https://doi.org/10.1016/j.oret.2018.06.009

© 2018 Purpose: To evaluate outcomes of epiretinal membrane (ERM) surgery in eyes with subretinal drusenoid deposits (SRDDs) and to compare them with those with isolated ERM. Design: Retrospective case-control study of consecutive patients who underw... Read More about Epiretinal Membrane Surgery Outcomes in Eyes with Subretinal Drusenoid Deposits: A Case Control Study.

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPAR?) are disrupted by retinal disease-associated mutations (2017)
Journal Article
Fulton, J., Mazumder, B., Whitchurch, J., Monteiro, C. J., Collins, H. M., Chan, C. M., …Heery, D. M. (2017). Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death and Disease, 8, Article e2677. https://doi.org/10.1038/cddis.2017.98

Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the Nuclear Receptor (NR) superfamily of transcription factors. We assessed... Read More about Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPAR?) are disrupted by retinal disease-associated mutations.

The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells. (2014)
Journal Article
Amoaku, W., Saker, S., Stewart, E. A., Browning, A. C., & Allen, C. L. (2014). The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells. Experimental Eye Research, 121, 161-167. https://doi.org/10.1016/j.exer.2014.02.016

Diabetic retinopathy is the leading cause of preventable blindness in the working population and its prevalence continues to increase as the worldwide prevalence of diabetes grows. Diabetic choroidopathy is less well studied and occurs in the late st... Read More about The effect of hyperglycaemia on permeability and the expression of junctional complex molecules in human retinal and choroidal endothelial cells..