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All Outputs (6)

Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion (2020)
Journal Article
Raposo, T. P., Susanti, S., & Ilyas, M. (2020). Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion. Advanced Biosystems, 4(6), https://doi.org/10.1002/adbi.202000031

TNS4 (Tensin 4 or Cten) is a putative oncogene in colorectal cancer (CRC) with a role in regulating cell adhesion, motility, invasion, and epithelial to mesenchymal transition (EMT). The objective is to study the role of TNS4 in CRC using more realis... Read More about Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.

Cten promotes Epithelial–Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src (2019)
Journal Article
Asiri, A., Toss, M. S., Raposo, T. P., Akhlaq, M., Thorpe, H., Alfahed, A., …Ilyas, M. (2019). Cten promotes Epithelial–Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src. Pathology International, 69(7), 381-391. https://doi.org/10.1111/pin.12811

Cten is an oncogene promoting EMT in many signaling pathways, namely through Snail. We investigated whether Cten function could be mediated through Src. Cten levels were modulated by forced expression in HCT116 and gene knockdown in SW620 CRC (colore... Read More about Cten promotes Epithelial–Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src.

TGF?1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer (2018)
Journal Article
Asiri, A., Raposo, T. P., Alfahed, A., & Ilyas, M. (2018). TGF?1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer. International Journal of Experimental Pathology, 99(6), 323-330. https://doi.org/10.1111/iep.12300

Cten (C-terminal tensin-like) is a member of the tensin protein family found in complex with integrins at focal adhesions. It promotes epithelial?mesenchymal transition (EMT) and cell motility. The precise mechanisms regulating Cten are unknown, alth... Read More about TGF?1-induced cell motility but not cell proliferation is mediated through Cten in colorectal cancer.

CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer (2018)
Journal Article
Raposo, T., Comes, M. S., Idowu, A., Agit, B., Hassall, J., Fadhil, W., …Ilyas, M. (2018). CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Experimental and Molecular Pathology, 104(3), https://doi.org/10.1016/j.yexmp.2018.04.002

Introduction CD10 is a cell membrane-bound endopeptidase which is expressed in normal small bowel but not in normal colon. It is aberrantly expressed in a small proportion of colorectal cancers (CRC) and this has been associated with liver metastasi... Read More about CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer.

Comparative aspects of canine and human inflammatory breast cancer (2017)
Journal Article
Raposo, T., Arias-Pulido, H., Chaher, N., Fiering, S. N., Argyle, D. J., Prada, J., …Queiroga, F. L. (in press). Comparative aspects of canine and human inflammatory breast cancer. Seminars in Oncology, 44(4), https://doi.org/10.1053/j.seminoncol.2017.10.012

Inflammatory breast cancer (IBC) in humans is the most aggressive form of mammary gland cancer and shares clinical, pathologic, and molecular patterns of disease with canine inflammatory mammary carcinoma (CIMC). Despite the use of multimodal therape... Read More about Comparative aspects of canine and human inflammatory breast cancer.

A refined method to study gene dosage changes in-vitro using CRISPR/Cas9 (2017)
Journal Article
Raposo, T., Ebili, H., & Ilyas, M. (in press). A refined method to study gene dosage changes in-vitro using CRISPR/Cas9. Journal of Clinical Pathology, 71(3), https://doi.org/10.1136/jclinpath-2017-204558

Aims: Gene dosage can have a major impact on cell biology although, hitherto, is has been difficult to study using in-vitro models. We sought to refine and accelerate the development of “gene dosage” models through using CRISPR/Cas9 (a gene-editing t... Read More about A refined method to study gene dosage changes in-vitro using CRISPR/Cas9.