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All Outputs (8)

An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification (2020)
Journal Article
Millar, S. A., John, S. G., McIntyre, C. W., Ralevic, V., Anderson, S. I., & O'Sullivan, S. E. (2020). An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification. Frontiers in Endocrinology, 11, https://doi.org/10.3389/fendo.2020.00369

© Copyright © 2020 Millar, John, McIntyre, Ralevic, Anderson and O'Sullivan. Osteocalcin (OCN) is a bone-derived protein that is detected within human calcified vascular tissue. Calcification is particularly prevalent in chronic kidney disease (CKD)... Read More about An Investigation Into the Role of Osteocalcin in Human Arterial Smooth Muscle Cell Calcification.

Osteocalcin does not influence acute or chronic inflammation in human vascular cells (2019)
Journal Article
Millar, S. A., Zala, I., Anderson, S. I., & O'Sullivan, S. E. (2020). Osteocalcin does not influence acute or chronic inflammation in human vascular cells. Journal of Cellular Physiology, 235(4), 3414-3424. https://doi.org/10.1002/jcp.29231

Some human observational studies have suggested an anti-inflammatory role of osteocalcin (OCN). An inflammatory protocol using IFN-γ and TNF-α (10 ng/mL) was employed to examine the acute (24 hr) and chronic (144 hr) effects of uncarboxylated OCN (uc... Read More about Osteocalcin does not influence acute or chronic inflammation in human vascular cells.

Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2 (2019)
Journal Article
Millar, S. A., Anderson, S. I., & O'Sullivan, S. E. (2019). Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2. PeerJ, 7, https://doi.org/10.7717/peerj.7139

Bone-derived factors that demonstrate extra-skeletal functions, also termed osteokines, are fast becoming a highly interesting and focused area of cross-disciplinary endocrine research. Osteocalcin (OCN), fibroblast growth factor-23 (FGF23) and lipoc... Read More about Osteokines and the vasculature: a review of the in vitro effects of osteocalcin, fibroblast growth factor-23 and lipocalin-2.

Human vascular cell responses to the circulating bone hormone osteocalcin (2019)
Journal Article
Millar, S. A., Anderson, S. I., & O'sullivan, S. E. (2019). Human vascular cell responses to the circulating bone hormone osteocalcin. Journal of Cellular Physiology, 234(11), 21039-21048. https://doi.org/10.1002/jcp.28707

The purpose of this study was to characterize the direct effects of uncarboxylated osteocalcin (ucOCN) on vascular cell biology in vitro, to assess its potential function in pathophysiological conditions such as atherosclerosis. Human aortic endothel... Read More about Human vascular cell responses to the circulating bone hormone osteocalcin.

Osteocalcin, vascular calcification, and atherosclerosis: a systematic review and meta-analysis (2017)
Journal Article
Millar, S. A., Patel, H., Anderson, S. I., England, T. J., & O'Sullivan, S. (2017). Osteocalcin, vascular calcification, and atherosclerosis: a systematic review and meta-analysis. Frontiers in Endocrinology, 8, Article 183. https://doi.org/10.3389/fendo.2017.00183

Background: Osteocalcin (OC) is an intriguing hormone, concomitantly being the most abundant non-collagenous peptide found in the mineralized matrix of bone, and expanding the endocrine function of the skeleton with far reaching extra-osseous effects... Read More about Osteocalcin, vascular calcification, and atherosclerosis: a systematic review and meta-analysis.

Photoperiod-induced increases in bone mineral apposition rate in Siberian hamsters and the involvement of seasonal leptin changes (2017)
Journal Article
Kokolski, M., Ebling, F. J., Henstock, J. R., & Anderson, S. I. (2017). Photoperiod-induced increases in bone mineral apposition rate in Siberian hamsters and the involvement of seasonal leptin changes. Frontiers in Endocrinology, 8, Article 357. https://doi.org/10.3389/fendo.2017.00357

The adipokine leptin regulates energy balance, appetite, and reproductive maturation. Leptin also acts on bone growth and remodeling, but both osteogenic and anti-osteogenic effects have been reported depending on experimental conditions. Siberian ha... Read More about Photoperiod-induced increases in bone mineral apposition rate in Siberian hamsters and the involvement of seasonal leptin changes.

Endocannabinoids modulate human blood-brain barrier permeability in vitro (2015)
Journal Article
Hind, W. H., Tufarelli, C., Neophytou, M., Anderson, S. I., England, T. J., & O'Sullivan, S. (2015). Endocannabinoids modulate human blood-brain barrier permeability in vitro. British Journal of Pharmacology, 172(12), 3015-3027. https://doi.org/10.1111/bph.13106

Background and Purpose Endocannabinoids alter permeability at various epithelial barriers, and cannabinoid receptors and endocannabinoid levels are elevated by stroke, with potential neuroprotective effects. We therefore explored the role of endoc... Read More about Endocannabinoids modulate human blood-brain barrier permeability in vitro.