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Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk (2024)
Journal Article
Granata, S., Vivarelli, F., Morosini, C., Canistro, D., Paolini, M., & Fairclough, L. C. (2024). Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk. International Journal of Molecular Sciences, 25(5), Article 2737. https://doi.org/10.3390/ijms25052737

Tobacco smoking remains one of the leading causes of premature death worldwide. Electronic Nicotine Delivery Systems (ENDSs) are proposed as a tool for smoking cessation. In the last few years, a growing number of different types of ENDSs were launch... Read More about Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk.

Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial (2023)
Journal Article
Ayling, K., Brown, M., Carlisle, S., Bennett, R., Buchanan, H., Dumbleton, J., …Vedhara, K. (2023). Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial. Health Psychology, 43(2), 77-88. https://doi.org/10.1037/hea0001267

Objective: This trial explored the psychological and immunological effects of two brief interventions, targeting improving positive mood, administered to older adults immediately prior to influenza vaccination. The primary aim was to examine whether... Read More about Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial.

Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study (2023)
Journal Article
Gumber, L., Jackson, H., Gomez, N., Hopkins, G., Tucis, D., Chakravorty, M., …Fairclough, L. (in press). Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study. Rheumatology Advances in Practice, Article rkad097. https://doi.org/10.1093/rap/rkad097

Objectives Antibody response to COVID-19 vaccines are reduced among immunocompromised patients but are not well-quantified among people with rare disease. We conducted an observational study to evaluate the antibody responses to the booster SARS-CoV-... Read More about Antibody response to four doses of SARS-CoV-2 vaccine in rare autoimmune rheumatic diseases: an observational study.

PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model (2023)
Journal Article
Gomez, N. E., James, V., Arkill, K. P., Nizamudeen, Z. A., Onion, D., & Fairclough, L. C. (2023). PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. European Journal of Immunology, 53(6), Article 2250143. https://doi.org/10.1002/eji.202250143

Extracellular vesicles (EVs) function as mediators of intercellular communication and as such influence the recipient cell function. EVs derived from immune cells can carry out many of the same functions as their parental cells, as they carry costimu... Read More about PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model.

Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination (2022)
Journal Article
Gumber, L., Gomez, N., Hopkins, G., Tucis, D., Bartlett, L., Ayling, K., …Fairclough, L. (2023). Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination. Rheumatology, 62(6), 2294-2303. https://doi.org/10.1093/rheumatology/keac574

Objectives: COVID-19 vaccine responses in rare autoimmune rheumatic diseases (RAIRD) remain poorly understood, in particular there is little known about whether people develop effective T-cell responses. We conducted a prospective cohort study to eva... Read More about Humoral and cellular immunity in patients with rare autoimmune rheumatic diseases following SARS-CoV-2 vaccination.

The Role of Lipids in Allergic Sensitization: A Systematic Review (2022)
Journal Article
Hopkins, G. V., Cochrane, S., Onion, D., & Fairclough, L. C. (2022). The Role of Lipids in Allergic Sensitization: A Systematic Review. Frontiers in Molecular Biosciences, 9, Article 832330. https://doi.org/10.3389/fmolb.2022.832330

Background: Immunoglobulin E (IgE)-mediated allergies are increasing in prevalence, with IgE-mediated food allergies currently affecting up to 10% of children and 6% of adults worldwide. The mechanisms underpinning the first phase of IgE-mediated all... Read More about The Role of Lipids in Allergic Sensitization: A Systematic Review.

Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review (2022)
Journal Article
Gomez, N., James, V., Onion, D., & Fairclough, L. C. (2022). Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review. Respiratory Research, 23, Article 82. https://doi.org/10.1186/s12931-022-01984-0

Background: Chronic Obstructive Pulmonary Disease (COPD) is a common inflammatory disease of the airways characterized by irreversible airflow limitation, ranking the third highest cause of death worldwide. Extracellular vesicles (EVs) are important... Read More about Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review.

Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept (2022)
Journal Article
Vedhara, K., Ayling, K., Jia, R., Fairclough, L., Morling, J. R., Ball, J. K., …Tighe, P. (2022). Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept. Journal of Infectious Diseases, 225(12), 2137-2141. https://doi.org/10.1093/infdis/jiac006

Background: Psychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Participants (n=102) completed mea... Read More about Relationship between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept.

Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers (2021)
Journal Article
Scurr, M. J., Zelek, W. M., Lippiatt, G., Somerville, M., Burnell, S. E., Capitani, L., …Godkin, A. (2022). Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers. Immunology, 165(2), 250-259. https://doi.org/10.1111/imm.13433

Accurate assessment of SARS-CoV-2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T-cell responses are a critical... Read More about Whole blood‐based measurement of SARS‐CoV‐2‐specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid‐organ cancers.

Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity (2021)
Journal Article
Albogami, S., Todd, I., Negm, O., Fairclough, L. C., & Tighe, P. J. (2021). Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity. Immunology, https://doi.org/10.1111/imm.13400

The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine-rich domains (CRD) in their extracellular regions, and the membrane-distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a p... Read More about Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild-type TNFR1 activity.

Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements (2021)
Journal Article
Hamed, A., Todd, I., Tighe, P. J., Powell, R. J., Harrison, T., & Fairclough, L. (2021). Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements. Journal of Immunological Methods, 492, Article 112999. https://doi.org/10.1016/j.jim.2021.112999

© 2021 Elsevier B.V. Skin prick testing (SPT) and measurement of serum allergen-specific IgE (sIgE) are used to investigate asthma and other allergic conditions. Measurement of serum total IgE (tIgE) and allergen-specific IgG4 (sIgG4) may also be use... Read More about Array-based measurements of aero-allergen-specific IgE correlate with skin-prick test reactivity in asthma regardless of specific IgG4 or total IgE measurements.

Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study (2020)
Journal Article
Blake, H., Corner, J., Cirelli, C., Hassard, J., Briggs, L., Daly, J. M., …Ball, J. (2021). Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study. International Journal of Environmental Research and Public Health, 18(1), 1-26. https://doi.org/10.3390/ijerph18010188

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. We aimed to explore student and staff perceptions and experiences of a pilot SARS-CoV-2 asymptomatic testing service (P-ATS) in a UK university campus setting. This was a mixed-method study co... Read More about Perceptions and Experiences of the University of Nottingham Pilot SARS-CoV-2 Asymptomatic Testing Service: A Mixed-Methods Study.

Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis (2020)
Journal Article
Vedhara, K., Royal, S., Sunger, K., Caldwell, D. M., Halliday, V., Taylor, C. M., …Welton, N. J. (2021). Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis. Health Psychology Review, 15(2), 245-271. https://doi.org/10.1080/17437199.2020.1854050

© 2020 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Psychological and behavioural may enhance vaccine effectiveness. We conducted a systematic review and network meta-analysis (NMA) to examine the effects of non-pharmacologi... Read More about Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis.

The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review (2020)
Journal Article
Williams, M., Todd, I., & Fairclough, L. C. (2020). The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review. Inflammation Research, https://doi.org/10.1007/s00011-020-01408-z

© 2020, The Author(s). Objective and design: This systematic review aims to establish the role of CD8 + T lymphocytes in COPD. Methods: Forty-eight papers published in the last 15years were identified for inclusion. Results: CD8 + T-cells are increas... Read More about The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review.

Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells (2020)
Journal Article
Chen, I. L., Todd, I., Tighe, P. J., & Fairclough, L. C. (2020). Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells. Archives of Toxicology, 94(6), 2097-2112 . https://doi.org/10.1007/s00204-020-02757-8

© 2020, The Author(s). Dendritic cells (DCs) are professional antigen presenting cells that play a critical role in bridging innate and adaptive immunity. Numerous studies have shown that tobacco constituents present in conventional cigarettes affect... Read More about Electronic cigarette vapour moderately stimulates pro-inflammatory signalling pathways and interleukin-6 production by human monocyte-derived dendritic cells.

Extracellular vesicles and asthma: A review of the literature (2020)
Journal Article
Sangaphunchai, P., Todd, I., & Fairclough, L. C. (2020). Extracellular vesicles and asthma: A review of the literature. Clinical and Experimental Allergy, 50(3), 291-307. https://doi.org/10.1111/cea.13562

© 2020 John Wiley & Sons Ltd Asthma is a chronic, recurrent and incurable allergy-related respiratory disease characterized by inflammation, bronchial hyperresponsiveness and narrowing of the airways. Extracellular vesicles (EVs) are a universal fe... Read More about Extracellular vesicles and asthma: A review of the literature.

Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes (2019)
Journal Article
Nair, N., Hurley, M., Gates, S., Davies, P., Chen, I. L., Todd, I., …Bhatt, M. (2020). Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes. Archives of Disease in Childhood, 105(11), 1114-1116. https://doi.org/10.1136/archdischild-2019-317889

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. We report a case of hypersensitivity pneumonitis (HP) in a young person secondary to vaping. He presented with a putative diagnosis of asthma... Read More about Life-threatening hypersensitivity pneumonitis secondary to e-cigarettes.

Mood and influenza vaccination in older adults: A randomized controlled trial. (2019)
Journal Article
Ayling, K., Fairclough, L., Buchanan, H., Wetherell, M. A., & Vedhara, K. (2019). Mood and influenza vaccination in older adults: A randomized controlled trial. Health Psychology, 38(11), 984-996. https://doi.org/10.1037/hea0000786

Objective: Positive mood on the day of vaccination has been associated with subsequent antibody responses to the influenza vaccine in older adults. The primary aim of this trial was to examine whether a brief intervention was able to enhance positive... Read More about Mood and influenza vaccination in older adults: A randomized controlled trial..