Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial
(2019)
Journal Article
Chappell, L. C., Bell, J. L., Smith, A., Linsell, L., Juszczak, E., Dixon, P. H., …Tan, B. (2019). Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet, 394(10201), 849-860. https://doi.org/10.1016/s0140-6736%2819%2931270-x
All Outputs (16)
Randomised trial of cord clamping at very preterm birth: outcomes at 2 years (2019)
Journal Article
Armstrong-Buisseret, L., Powers, K., Dorling, J., Bradshaw, L., Johnson, S., Mitchell, E., & Duley, L. (2020). Randomised trial of cord clamping at very preterm birth: outcomes at 2 years. Archives of Disease in Childhood. Fetal and Neonatal Edition, 105(3), 292-298. https://doi.org/10.1136/archdischild-2019-316912Objective: To report outcomes at 2 years corrected age for children of women recruited to a trial comparing alternative policies for timing of cord clamping and immediate neonatal care at very preterm birth. Design: Parallel group randomised (1:1... Read More about Randomised trial of cord clamping at very preterm birth: outcomes at 2 years.
Full Milk Feeds from Day 1 (2019)
Journal Article
Ojha, S., Mitchell, E., Montgomery, A., & Dorling, J. (2019). Full Milk Feeds from Day 1. Neonatology, 116(1), https://doi.org/10.1159/000499676
Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age (2019)
Journal Article
Shipley, L. J., Gyorkos, T., Jon, D., Tata, L. J., Lisa, S., & Sharkey, D. (2019). Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age. Pediatric Critical Care Medicine, 20(7), 638-644. https://doi.org/10.1097/PCC.0000000000001937Objectives: Evaluate the risk of severe intraventricular hemorrhage, in the first week of life, in preterm infants undergoing early interhospital transport. Design: Retrospective cohort study. Setting: Tertiary neonatal centers of the Trent Per... Read More about Risk of severe intraventricular haemorrhage in the first week of life in preterm infants transported before 72 hours of age.
Enteral lactoferrin to prevent infection for very preterm infants: the ELFIN RCT (2018)
Journal Article
Griffiths, J., Jenkins, P., Vargova, M., Bowler, U., Juszczak, E., King, A., …Oddie, S. (2018). Enteral lactoferrin to prevent infection for very preterm infants: the ELFIN RCT. Health Technology Assessment, 22(74), 1-60. https://doi.org/10.3310/hta22740
Optimising nutrition during therapeutic hypothermia (2018)
Journal Article
Ojha, S., Dorling, J., Battersby, C., Longford, N., & Gale, C. (2019). Optimising nutrition during therapeutic hypothermia. Archives of Disease in Childhood. Fetal and Neonatal Edition, 104(3), F230-F231. https://doi.org/10.1136/archdischild-2018-315393There is little evidence to inform provision of enteral or parenteral nutrition to infants with hypoxic ischaemic encephalopathy (HIE) during and soon after therapeutic hypothermia; as a consequence, clinical practice is both variable and changing. A... Read More about Optimising nutrition during therapeutic hypothermia.
Antacid therapy for gastroesophageal reflux in preterm infants: a systematic review (2018)
Journal Article
Dermyshi, E., Mackie, C., Kigozi, P., Schoonakker, B., & Dorling, J. (2018). Antacid therapy for gastroesophageal reflux in preterm infants: a systematic review. BMJ Paediatrics Open, 2(1), Article e00028. https://doi.org/10.1136/bmjpo-2018-000287Background: Gastro-oesophageal reflux is prevalent in preterm infants. Despite widespread use in clinical practice, there is still much controversy over the efficacy and safety of drug interventions, particularly antacid therapy. Objective: To syste... Read More about Antacid therapy for gastroesophageal reflux in preterm infants: a systematic review.
Feed thickeners in gastro-oesophageal reflux in infants (2018)
Journal Article
Kwok, T. C., Ojha, S., & Dorling, J. (2018). Feed thickeners in gastro-oesophageal reflux in infants. BMJ Paediatrics Open, 2(1), e000262. https://doi.org/10.1136/bmjpo-2018-000262Gastro-oesophageal reflux (GOR) is the involuntary retrograde passage of gastric contents into the oesophagus with or without regurgitation. This is a common physiological, self-limiting condition in healthy infants with a prevalence peaking at 3–4 m... Read More about Feed thickeners in gastro-oesophageal reflux in infants.
Feed thickener for infants up to six months of age with gastro-oesophageal reflux (Review) (2017)
Journal Article
Kwok, T. C., Ojha, S., & Dorling, J. (in press). Feed thickener for infants up to six months of age with gastro-oesophageal reflux (Review). Cochrane Database of Systematic Reviews, Article CD003211. https://doi.org/10.1002/14651858.CD003211.pub2Background Gastro-oesophageal reflux (GOR) is common in infants, and feed thickeners are often used to manage it in infants as they are simple to use and perceived to be harmless. However, conflicting evidence exists to support the use of feed thick... Read More about Feed thickener for infants up to six months of age with gastro-oesophageal reflux (Review).
Randomised trial of cord clamping and initial stabilisation at very preterm birth (2017)
Journal Article
Duley, L., Dorling, J., Pushpa-Rajah, A., Oddie, S. J., Yoxall, C. W., Schoonakker, B., …Fawke, J. A. (2018). Randomised trial of cord clamping and initial stabilisation at very preterm birth. Archives of Disease in Childhood. Fetal and Neonatal Edition, 103(1), F6-F14. https://doi.org/10.1136/archdischild-2016-312567© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. OBJECTIVES: For very preterm births, to compare alternative po... Read More about Randomised trial of cord clamping and initial stabilisation at very preterm birth.
Fifteen minute consultation: stabilisaton of the high risk newborn infant beside the mother (2017)
Journal Article
Batey, N., Yoxall, B., Fawke, J., Duley, L., & Dorling, J. (2017). Fifteen minute consultation: stabilisaton of the high risk newborn infant beside the mother. Archives of Disease in Childhood, 102, https://doi.org/10.1136/archdischild-2016-312276Paediatric and adult resuscitation is often performed with family present. Current guidelines recommend deferred umbilical cord clamping as part of immediate neonatal care, requiring neonatal assessment next to the mother. This paper describes strate... Read More about Fifteen minute consultation: stabilisaton of the high risk newborn infant beside the mother.
Multicentre prospective observational study of feeding practices in 30–33 weeks preterm infants (2017)
Journal Article
Kwok, T., Kwok, T., Dorling, J., Dorling, J., Ojha, S., & Ojha, S. (2017). Multicentre prospective observational study of feeding practices in 30–33 weeks preterm infants. BMJ Paediatrics Open, 1(1), 1-4. https://doi.org/10.1136/bmjpo-2017-000040Background: Current evidence supports progressive feeding in preterm infants. Due to lower necrotising enterocolitis risk, recent studies suggest starting total enteral feeding from birth in 30–33 weeks preterm infants. The feasibility of this practi... Read More about Multicentre prospective observational study of feeding practices in 30–33 weeks preterm infants.
The speed of increasing milk feeds: a randomised controlled trial (2017)
Journal Article
Abbott, J., Berrington, J., Bowler, U., Boyle, E., Dorling, J., Embleton, N., …Stenson, B. (in press). The speed of increasing milk feeds: a randomised controlled trial. BMC Pediatrics, 17(1), Article 39. https://doi.org/10.1186/s12887-017-0794-zBACKGROUND In the UK, 1-2% of infants are born very preterm (
Cord pilot trial: update to randomised trial protocol (2015)
Journal Article
on behalf of the Cord Pilot Trial Collaborative Group, , Bradshaw, L. E., Pushpa-Rajah, A., Dorling, J., Mitchell, E. J., & Duley, L. (2015). Cord pilot trial: update to randomised trial protocol. Trials, 16(1), 1-3. https://doi.org/10.1186/s13063-015-0936-2Background: The Cord Pilot Trial aimed to assess the feasibility of conducting a large UK randomised trial to compare the effects of alternative polices for timing of cord clamping (immediate within 20 seconds or deferred after at least 2 minutes) fo... Read More about Cord pilot trial: update to randomised trial protocol.
Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial (2014)
Journal Article
Pushpa-Rajah, A., Bradshaw, L., Dorling, J., Gyte, G., Mitchell, E. J., Thornton, J., & Duley, L. (2014). Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial. Trials, 15(258), https://doi.org/10.1186/1745-6215-15-258Background: Preterm birth is the most important single determinant of adverse outcome in the United Kingdom; one in every 70 babies (1.4%) is born before 32 weeks (very preterm), yet these births account for over half of infant deaths. Deferring cor... Read More about Cord pilot trial - immediate versus deferred cord clamping for very preterm birth (before 32 weeks gestation): study protocol for a randomized controlled trial.
Elective preterm birth for fetal gastroschisis (Review) (2013)
Journal Article
Grant, N. H., Dorling, J., & Thornton, J. (2013). Elective preterm birth for fetal gastroschisis (Review). Cochrane Database of Systematic Reviews, 2013(6), Article CD009394. https://doi.org/10.1002/14651858.CD009394.pub2Background: Gastroschisis is an uncommon congenital defect of the interior abdominal wall that results in herniation of intestinal loops outside the abdominal cavity. Babies with gastroschisis generally do well, but there remains a mortality rate of... Read More about Elective preterm birth for fetal gastroschisis (Review).