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Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus (2020)
Journal Article
Hockley, A., Berger, J. I., Palmer, A. R., & Wallace, M. N. (2020). Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus. European Journal of Neuroscience, 52(9), 4057-4080. https://doi.org/10.1111/ejn.14913

Previous work has led to the hypothesis that, during the production of noise?induced tinnitus, higher levels of nitric oxide (NO), in the ventral cochlear nucleus (VCN), increase the gain applied to a reduced input from the cochlea. To test this hypo... Read More about Nitric oxide increases gain in the ventral cochlear nucleus of guinea pigs with tinnitus.

Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus (2019)
Journal Article
Hockley, A., Berger, J. I., Smith, P. A., Palmer, A. R., & Wallace, M. N. (2020). Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus. European Journal of Neuroscience, 51(4), 963-983. https://doi.org/10.1111/ejn.14572

The gaseous free radical, nitric oxide (NO) acts as a ubiquitous neuromodulator, contributing to synaptic plasticity in a complex way that can involve either long term potentiation or depression. It is produced by neuronal nitric oxide synthase (nNOS... Read More about Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus.

Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs (2019)
Journal Article
Wilson, C. A., Berger, J. I., de Boer, J., Sereda, M., Palmer, A. R., Hall, D. A., & Wallace, M. N. (2019). Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs. Hearing Research, 374, 13-23. https://doi.org/10.1016/j.heares.2019.01.009

A common method for measuring changes in temporal processing sensitivity in both humans and animals makes use of GaP-induced Inhibition of the Acoustic Startle (GPIAS). It is also the basis of a common method for detecting tinnitus in rodents. Howeve... Read More about Gap-induced inhibition of the post-auricular muscle response in humans and guinea pigs.

Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals (2017)
Journal Article
Berger, J. I., Owen, W., Wilson, C. A., Hockley, A., Coomber, B., Palmer, A. R., & Wallace, M. N. (2018). Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals. Brain Research, 1679, https://doi.org/10.1016/j.brainres.2017.11.026

Animal models of tinnitus are essential for determining the underlying mechanisms and testing pharmacotherapies. However, there is doubt over the validity of current behavioural methods for detecting tinnitus. Here, we applied a stimulus paradigm wid... Read More about Gap-induced reductions of evoked potentials in the auditory cortex: a possible objective marker for the presence of tinnitus in animals.

Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs (2017)
Journal Article
Berger, J. I., Coomber, B., Hill, S., Alexander, S., Owen, W., Palmer, A. R., & Wallace, M. N. (in press). Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs. Hearing Research, https://doi.org/10.1016/j.heares.2017.10.012

Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine... Read More about Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs.

Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs (2016)
Journal Article
Berger, J. I., Coomber, B., Wallace, M. N., & Palmer, A. R. (2017). Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs. European Journal of Neuroscience, 45(3), https://doi.org/10.1111/ejn.13474

Tinnitus chronically affects between 10–15% of the population but, despite its prevalence, the underlying mechanisms are still not properly understood. One experimental model involves administration of high doses of sodium salicylate, as this is know... Read More about Reductions in cortical alpha activity, enhancements in neural responses and impaired gap detection caused by sodium salicylate in awake guinea pigs.