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Alcohol Dehydrogenase?triggered Oxa?Michael Reaction for the Asymmetric Synthesis of Disubstituted Tetrahydropyrans and Tetrahydrofurans (2019)
Journal Article
Eastman, H., Ryan, J., Maciá, B., Caprio, V., & O'Reilly, E. (2019). Alcohol Dehydrogenase‐triggered Oxa‐Michael Reaction for the Asymmetric Synthesis of Disubstituted Tetrahydropyrans and Tetrahydrofurans. ChemCatChem, 11(16), 3760-3762. https://doi.org/10.1002/cctc.201900658

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim An alcohol dehydrogenase-mediated asymmetric reduction and subsequent intramolecular oxa-Michael reaction has been developed for the preparation of tetrahydropyrans (or oxanes) and tetrahydrofurans,... Read More about Alcohol Dehydrogenase?triggered Oxa?Michael Reaction for the Asymmetric Synthesis of Disubstituted Tetrahydropyrans and Tetrahydrofurans.

Conversion of aldoses to valuable ?-amino alcohols using amine transaminase biocatalysts (2018)
Journal Article
Cairns, R., Gomm, A., Ryan, J., Clarke, T., Kulcinskaja, E., Butler, K., & O’Reilly, E. (2019). Conversion of aldoses to valuable ω-amino alcohols using amine transaminase biocatalysts. ACS Catalysis, 9(2), 1220-1223. https://doi.org/10.1021/acscatal.8b04564

The conversion of readily available monosaccharides to high-value amino alcohols using a key biocatalytic step is an attractive strategy for the preparation of these chiral synthons. Here, we report a previously undescribed example of the direct ami... Read More about Conversion of aldoses to valuable ?-amino alcohols using amine transaminase biocatalysts.

Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations (2018)
Journal Article
Gomm, A., Grigoriou, S., Peel, C., Ryan, J., Mujtaba, N., Clarke, T., …O'Reilly, E. (2018). Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations. European Journal of Organic Chemistry, 2018(38), 5282-5284. https://doi.org/10.1002/ejoc.201800799

The 'smart' amine donors o‐xylylenediamine and cadaverine were employed for the rapid screening of a large ketone library and subsequent preparative‐scale synthesis of selected compounds using the commercially available amine transaminase, ATA256. Th... Read More about Application of 'smart' amine donors for rapid screening and scale-up of transaminase-mediated biotransformations.

Modified dipole-dipole interaction and dissipation in an atomic ensemble near surfaces (2018)
Journal Article
Jones, R., Needham, J. A., Lesanovsky, I., Intravaia, F., & Olmos, B. (2018). Modified dipole-dipole interaction and dissipation in an atomic ensemble near surfaces. Physical Review A, 97(5), Article 053841. https://doi.org/10.1103/PhysRevA.97.053841

We study how the radiative properties of a dense ensemble of atoms can be modified when they are placed near or between metallic or dielectric surfaces. If the average separation between the atoms is comparable or smaller than the wavelength of the s... Read More about Modified dipole-dipole interaction and dissipation in an atomic ensemble near surfaces.

Far-field resonance fluorescence from a dipole-interacting laser-driven cold atomic gas (2016)
Journal Article
Jones, R., Saint, R., & Olmos, B. (in press). Far-field resonance fluorescence from a dipole-interacting laser-driven cold atomic gas. Journal of Physics B: Atomic, Molecular and Optical Physics, 50(1), https://doi.org/10.1088/1361-6455/50/1/014004

We analyze the temporal response of the fluorescence light that is emitted from a dense gas of cold atoms driven by a laser. When the average interatomic distance is comparable to the wavelength of the photons scattered by the atoms, the system exhib... Read More about Far-field resonance fluorescence from a dipole-interacting laser-driven cold atomic gas.

Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds (2016)
Journal Article
Ryan, J., Šiaučiulis, M., Gomm, A., Macia, B., O'Reilly, E., & Caprio, V. (in press). Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds. Journal of the American Chemical Society, 138(49), https://doi.org/10.1021/jacs.6b07024

The expanding “toolbox” of biocatalysts opens new opportunities to redesign synthetic strategies to target molecules by incorporating a key enzymatic step into the synthesis. Herein, we describe a general biocatalytic approach for the enantioselectiv... Read More about Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds.