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Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article
Stubbendorff, C., Hale, E., Bast, T., Cassaday, H. J., Martin, S. J., Suwansawang, S., …Stevenson, C. W. (2023). Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear. Scientific Reports, 13, Article 17631. https://doi.org/10.1038/s41598-023-44772-6

Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.

Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries (2023)
Journal Article
Cassaday, H. J., Cavenagh, L., Aluthgamage, H., Crooks, A., Bonardi, C., Stevenson, C. W., …Muir, C. (2023). Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries. PLoS ONE, 18(8), Article e0290232. https://doi.org/10.1371/journal.pone.0290232

Three groups of participants (largely recruited from the UK) completed a survey to examine attitudes to the use of animals in biomedical research, after reading the lay (N = 182) or technical (N = 201) summary of a research project, or no summary (N... Read More about Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries.

From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures (2023)
Journal Article
Cassaday, H. J., Muir, C., Stevenson, C. W., Bonardi, C., Hock, R., & Waite, L. (2023). From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures. Neurobiology of Learning and Memory, 202, Article 107757. https://doi.org/10.1016/j.nlm.2023.107757

Inhibitory associative learning counters the effects of excitatory learning, whether appetitively or aversively motivated. Moreover, the affective responses accompanying the inhibitory associations are of opponent valence to the excitatory conditione... Read More about From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures.

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats (2022)
Journal Article
Warren, W. G., Papagianni, E. P., Hale, E., Brociek, R. A., Cassaday, H. J., & Stevenson, C. W. (2022). Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats. Frontiers in Pharmacology, 13, Article 1082760. https://doi.org/10.3389/fphar.2022.1082760

Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinct... Read More about Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats.

Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance (2022)
Journal Article
Papagianni, E. P., Warren, W. G., Cassaday, H. J., & Stevenson, C. W. (2022). Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance. International Journal of Molecular Sciences, 23(16), Article 9333. https://doi.org/10.3390/ijms23169333

Cannabidiol, the main non-psychotropic constituent of cannabis, has potential as a treatment for anxiety-related disorders since it reduces learned fear expression and enhances fear extinction. The return of fear over time after successful extinction... Read More about Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance.

URB597 induces subtle changes to aggression in adult Lister Hooded rats (2022)
Journal Article
Warren, W. G., Hale, E., Papagianni, E. P., Cassaday, H. J., Stevenson, C. W., & Stubbendorff, C. (2022). URB597 induces subtle changes to aggression in adult Lister Hooded rats. Frontiers in Psychiatry, 13, Article 885146. https://doi.org/10.3389/fpsyt.2022.885146

The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on socia... Read More about URB597 induces subtle changes to aggression in adult Lister Hooded rats.

Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors (2022)
Journal Article
Marriott, S., & Cassaday, H. J. (2022). Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors. Humanities and Social Sciences Communications, 9(1), Article 138. https://doi.org/10.1057/s41599-022-01159-8

Attitudes to animals and their use are becoming increasingly important for the success of conservation and environmental initiatives. Beliefs about animals, their perceived emotional appeal, as well as individuals’ moral capacities are all likely dri... Read More about Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors.

Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns (2022)
Journal Article
Thurston, M. D., & Cassaday, H. J. (2022). Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns. Frontiers in Psychology, 13, Article 866771. https://doi.org/10.3389/fpsyg.2022.866771

Experimental studies of fear conditioning have identified the effectiveness of safety signals in inhibiting fear and maintaining fear-motivated behaviors. In fear conditioning procedures, the presence of safety signals means that the otherwise expect... Read More about Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns.

Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition (2022)
Journal Article
Williams, S. A., Gwilt, M., Hock, R., Taylor, C., Loayza, J., Stevenson, C. W., …Bast, T. (2022). Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition. eNeuro, 9(1), ENEURO.0270-21.2021. https://doi.org/10.1523/eneuro.0270-21.2021

Hippocampal neural disinhibition, i.e., reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition.

Strain comparisons in inhibitory discrimination learning and novel object recognition procedures (2021)
Journal Article
Waite, L., Bonardi, C., Stevenson, C. W., & Cassaday, H. J. (2021). Strain comparisons in inhibitory discrimination learning and novel object recognition procedures. Physiology and Behavior, 240, Article 113557. https://doi.org/10.1016/j.physbeh.2021.113557

Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetiti... Read More about Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.

Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat (2020)
Journal Article
Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2020). Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat. Journal of Psychopharmacology, 34(12), 1457-1460. https://doi.org/10.1177/0269881120965914

Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol... Read More about Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat.

Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use (2020)
Journal Article
Higgs, M. J., Bipin, S., & Cassaday, H. J. (2020). Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use. Royal Society Open Science, 7(2), 191162. https://doi.org/10.1098/rsos.191162

The animal purpose questionnaire (APQ) is a new instrument to measure human attitudes to animal use systematically across both species and purpose of use. This offers a more fine-grained approach to our understanding of how the belief in a specific a... Read More about Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use.

Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use (2020)
Journal Article
Bibby, P. A., Bradley, A., Mennie, N., Bibby, P. A., & Cassaday, H. J. (2020). Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use. PLoS ONE, 15(1), https://doi.org/10.1371/journal.pone.0227948

© 2020 Bradley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use.

Data showing regional differences in rat brain monoaminergic function (2019)
Journal Article
Nelson, A. .., & Cassaday, H. (2019). Data showing regional differences in rat brain monoaminergic function. Data in Brief, 27, https://doi.org/10.1016/j.dib.2019.104814

Chemical neurotransmitters (such as dopamine) modulate cognitive function via ascending projections to various cortical and sub-cortical brain regions. This report describes and links to a relatively large dataset (up to N=112) compiled from control... Read More about Data showing regional differences in rat brain monoaminergic function.

Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues (2019)
Journal Article
Cassaday, H., & Thur, K. (2019). Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues. Pharmacology Biochemistry and Behavior, 187, 1-6. https://doi.org/10.1016/j.pbb.2019.172797

The effects of the serotonergic (5-hydroxytryptamine, 5-HT) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.2 and 0.4 mg/kg i.p.) were examined in trace conditioning (Experiment 1) and overshadowing (Experiment 2) procedures. Both experi... Read More about Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues.

EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli (2019)
Journal Article
Cassaday, H. J., & Thur, K. E. (2020). EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli. Journal of Psychopharmacology, 34(1), 145-147. https://doi.org/10.1177/0269881119882855

Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known... Read More about EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli.

Age-related differences in appetitive trace conditioning and novel object recognition procedures (2019)
Journal Article
Marshall, H., Pezze, M., Fone, K., & Cassaday, H. (2019). Age-related differences in appetitive trace conditioning and novel object recognition procedures. Neurobiology of Learning and Memory, 164, https://doi.org/10.1016/j.nlm.2019.107041

Appetitive trace conditioning (TC) was examined over 6 months in younger-adult (2-8 months) and middle-aged (12-18 months) male Wistar RccHan rats to test for early age-related impairment in working memory. Novel object recognition (NOR) was included... Read More about Age-related differences in appetitive trace conditioning and novel object recognition procedures.

Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning (2019)
Journal Article
Stubbendorff, C., Hale, E., Cassaday, H. J., Bast, T., & Stevenson, C. W. (2019). Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning. Psychopharmacology, 236(6), 1771-1782. https://doi.org/10.1007/s00213-018-5162-7

Rationale Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or ba... Read More about Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning.

Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure (2018)
Journal Article
Pezze, M., Marshall, H., & Cassaday, H. (2018). Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure. Brain and Behavior, https://doi.org/10.1002/brb3.1147

Trace conditioning is impaired by lesions to dorsal hippocampus, as well as by treatment with the muscarinic acetylcholine antagonist scopolamine. However, the role of muscarinic receptors within hippocampus has received little attention. The present... Read More about Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure.

Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay (2017)
Journal Article
Pezze, M. A., Marshall, H. J., Fone, K. C., & Cassaday, H. J. (2017). Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay. Learning and Memory, 24(7), 310-317. https://doi.org/10.1101/lm.044784.116

Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesi... Read More about Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay.