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On the Meaning of Averages in Genome-wide Association Studies: What Should Come Next? (2023)
Journal Article
Rauch, C., Wattis, J., & Bray, S. (2023). On the Meaning of Averages in Genome-wide Association Studies: What Should Come Next?. Organisms, 6(1), 7-22. https://doi.org/10.13133/2532-5876/17811

Identifying the association between phenotypes and genotypes is the fundamental basis of genetic analyses. Although genomic technologies used to generate data have rapidly advanced within the last 20 years, the statistical models used in genome-wide... Read More about On the Meaning of Averages in Genome-wide Association Studies: What Should Come Next?.

GIFT: New method for the genetic analysis of small gene effects involving small sample sizes (2022)
Journal Article
Rauch, C., Kyratzi, P., Blott, S., Bray, S., & Wattis, J. A. D. (2023). GIFT: New method for the genetic analysis of small gene effects involving small sample sizes. Physical Biology, 20(1), Article 016001. https://doi.org/10.1088/1478-3975/ac99b3

Small gene effects involved in complex/omnigenic traits remain costly to analyse using current genome-wide association methods (GWAS) because of the number of individuals required to return meaningful association(s), a.k.a. study power. Inspired by f... Read More about GIFT: New method for the genetic analysis of small gene effects involving small sample sizes.

Analysis of phenotype-genotype associations using genomic informational field theory (GIFT) (2022)
Journal Article
Wattis, J. A., Bray, S. M., Kyratzi, P., & Rauch, C. (2022). Analysis of phenotype-genotype associations using genomic informational field theory (GIFT). Journal of Theoretical Biology, 548, Article 111198. https://doi.org/10.1016/j.jtbi.2022.111198

We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known genotypes, we... Read More about Analysis of phenotype-genotype associations using genomic informational field theory (GIFT).

Lipid biophysics and/or soft matter-inspired approach for controlling enveloped virus infectivity (2022)
Journal Article
Al-dalawi, L., Dunham, S. P., & Rauch, C. (2022). Lipid biophysics and/or soft matter-inspired approach for controlling enveloped virus infectivity. Journal of the Royal Society. Interface, 19(189), Article 20210943. https://doi.org/10.1098/rsif.2021.0943

Proven as a natural barrier against viral infection, pulmonary surfactant phospholipids have a biophysical and immunological role within the respiratory system, acting against microorganisms including viruses. Enveloped viruses have, in common, an ou... Read More about Lipid biophysics and/or soft matter-inspired approach for controlling enveloped virus infectivity.

Pinocytosis as the Biological Mechanism That Protects Pgp Function in Multidrug Resistant Cancer Cells and in Blood–Brain Barrier Endothelial Cells (2020)
Journal Article
Omran, Z., Whitehouse, C., Halwani, M., Zamzami, M. A., Baothman, O. A., & Rauch, C. (2020). Pinocytosis as the Biological Mechanism That Protects Pgp Function in Multidrug Resistant Cancer Cells and in Blood–Brain Barrier Endothelial Cells. Symmetry, 12(8), Article 1221. https://doi.org/10.3390/sym12081221

Cancer is the second leading cause of death worldwide. Chemotherapy has shown reasonable success in treating cancer. However, multidrug resistance (MDR), a phenomenon by which cancerous cells become resistant to a broad range of functionally and stru... Read More about Pinocytosis as the Biological Mechanism That Protects Pgp Function in Multidrug Resistant Cancer Cells and in Blood–Brain Barrier Endothelial Cells.

Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway (2020)
Journal Article
Burton, L., Scaife, P., Paine, S. W., Mellor, H. R., Abernethy, L., Littlewood, P., & Rauch, C. (2020). Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway. American Journal of Physiology - Cell Physiology, 318(5), C889-C902. https://doi.org/10.1152/ajpcell.00472.2019

Approximately 75% of xenobiotics are primarily eliminated through metabolism; thus the accurate scaling of metabolic clearance is vital to successful drug development. Yet, when data is scaled from in vitro to in vivo, hepatic metabolic clearance, th... Read More about Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway.

A Mechanogenetic Model of Exercise-Induced Pulmonary Haemorrhage in the Thoroughbred Horse (2019)
Journal Article
Blott, S., Cunningham, H., Malkowski, L., Brown, A., & Rauch, C. (2019). A Mechanogenetic Model of Exercise-Induced Pulmonary Haemorrhage in the Thoroughbred Horse. Genes, 10(11), Article 880. https://doi.org/10.3390/genes10110880

Exercise-induced pulmonary haemorrhage (EIPH) occurs in horses performing high-intensity athletic activity. The application of physics principles to derive a ‘physical model’, which is coherent with existing physiology and cell biology data, shows th... Read More about A Mechanogenetic Model of Exercise-Induced Pulmonary Haemorrhage in the Thoroughbred Horse.

Physics of animal health: on the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., …Rauch, C. (2019). Physics of animal health: on the mechano-biology of hoof growth and form. Interface, 16(155), 1-12. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of animal health: on the mechano-biology of hoof growth and form.

Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness (2018)
Journal Article
Rayneau-Kirkhope, D., Mao, Y., & Rauch, C. (2018). Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness. Physical Review Applied, 10(3), 1-10. https://doi.org/10.1103/PhysRevApplied.10.034016

Throughout biology, geometric hierarchy is a recurrent theme in structures where strength is achieved with efficient material usage. Acting over vast timescales, evolution has brought about beautiful solutions to problems of mechanics that are only n... Read More about Bio-inspired hierarchical designs for stiff, strong interfaces between materials of differing stiffness.

Taking a broader view of things: towards a transdisciplinary approach to cancer (2017)
Journal Article
Rauch, C., Blott, S., & Stewart, S. (2017). Taking a broader view of things: towards a transdisciplinary approach to cancer. https://doi.org/10.13133/2532-5876_2.10

Cancer is widely considered an abnormality that emerges from within the body and which must be destroyed and defeated. But we still do not know precisely how and why cancer starts, and while a ‘magic bullet’ cure has failed to materialise, those adop... Read More about Taking a broader view of things: towards a transdisciplinary approach to cancer.

A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions (2017)
Journal Article
Cherkaoui-Rbati, M., Paine, S., Littlewood, P., & Rauch, C. (2017). A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions. PLoS ONE, 12(9), Article e0183794. https://doi.org/10.1371/journal.pone.0183794

All pharmaceutical companies are required to assess pharmacokinetic drug-drug interactions (DDIs) of new chemical entities (NCEs) and mathematical prediction helps to select the best NCE candidate with regard to adverse effects resulting from a DDI b... Read More about A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions.

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases (2017)
Journal Article
Harguindey, S., Stanciu, D., Devesa, J., Alfarouk, K., Cardone, R. A., Polo Orozco, J. D., …Reshkin, S. J. (2017). Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases. Seminars in Cancer Biology, 43, https://doi.org/10.1016/j.semcancer.2017.02.003

During the last few years, the understanding of the dysregulated hydrogen ion dynamics and reversed proton gradient of cancer cells has resulted in a new and integral pH-centric paradigm in oncology, a translational model embracing from cancer etiopa... Read More about Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases.

Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer (2017)
Journal Article
Omran, Z., Scaife, P., Stewart, S., & Rauch, C. (2017). Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer. Seminars in Cancer Biology, 43, https://doi.org/10.1016/j.semcancer.2017.01.002

The role of the Warburg effect in cancer remains to be elucidated with a resurgence in research efforts over the past decade. Why a cancer cell would prefer to use energy inefficient glycolysis, leading to an alteration of pH both inside and outside... Read More about Physical and biological characteristics of multi drug resistance (MDR): an integral approach considering pH and drug resistance in cancer.

The bio-physics of condensation of divalent cations into the bacterial wall has implications for growth of Gram-positive bacteria (2016)
Journal Article
Rauch, C., Cherkaoui-Rbati, M., Egan, S. A., & Leigh, J. A. (2017). The bio-physics of condensation of divalent cations into the bacterial wall has implications for growth of Gram-positive bacteria. BBA - Biomembranes, 1859(2), https://doi.org/10.1016/j.bbamem.2016.12.002

Background: The anionic-polyelectrolyte nature of the wall of Gram-positive bacteria has long been suspected to be involved in homeostasis of essential cations and bacterial growth. A better understanding of the coupling between the biophysics and th... Read More about The bio-physics of condensation of divalent cations into the bacterial wall has implications for growth of Gram-positive bacteria.

Rethinking therapeutic strategies in cancer: wars, fields, anomalies and monsters (2016)
Journal Article
Stewart, S., & Rauch, C. (in press). Rethinking therapeutic strategies in cancer: wars, fields, anomalies and monsters. Social Theory and Health, https://doi.org/10.1057/sth.2016.4

This article argues that the excessive focus on cancer as an insidious living defect that needs to be destroyed has obscured the fact that cancer develops inside human beings. Therefore, in order to contribute to debates about new cancer therapies, w... Read More about Rethinking therapeutic strategies in cancer: wars, fields, anomalies and monsters.

Theoretical evaluation of wall teichoic acids in the cavitation-mediated pores formation in Gram-positive bacteria subjected to an electric field (2014)
Journal Article
Rauch, C., & Leigh, J. A. (in press). Theoretical evaluation of wall teichoic acids in the cavitation-mediated pores formation in Gram-positive bacteria subjected to an electric field. BBA - General Subjects, 1850(4), https://doi.org/10.1016/j.bbagen.2014.12.004

Background: Electroporation is a method of choice to transform living cells. The ability of electroporation to transfer small or large chemicals across the lipid bilayer membrane of eukaryotic cells or Gram-negative bacteria relies on the formation o... Read More about Theoretical evaluation of wall teichoic acids in the cavitation-mediated pores formation in Gram-positive bacteria subjected to an electric field.

Physics of nail conditions: why do ingrown nails always happen in the big toes? (2014)
Journal Article
Rauch, C., & Cherkaoui-Rbati, M. (2014). Physics of nail conditions: why do ingrown nails always happen in the big toes?. Physical Biology, 11(6), Article 066004. https://doi.org/10.1088/1478-3975/11/6/066004

Although surgical treatment of nail conditions can be traced back centuries to the writings of Paul Aegineta (625–690 AC), little is known about the physical laws governing nail growth. Such a poor understanding together with the increasing number of... Read More about Physics of nail conditions: why do ingrown nails always happen in the big toes?.

Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated in vitro in cell cultures (2014)
Journal Article
Shubber, S., Vllasaliu, D., Rauch, C., Jordan, F., Illum, L., & Stolnik-Trenkic, S. (2015). Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated in vitro in cell cultures. Pharmaceutical Research, 32(2), 516-527. https://doi.org/10.1007/s11095-014-1481-5

Purpose: CriticalSorb™, with the principal component Solutol® HS15, is a novel mucosal drug delivery system demonstrated to improve the bioavailability of selected biotherapeutics. The intention of this study is to elucidate mechanism(s) responsible... Read More about Mechanism of mucosal permeability enhancement of CriticalSorb® (Solutol® HS15) investigated in vitro in cell cultures.