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Use of novel DNA methylation signatures to distinguish between human airway structural cell types (2017)
Conference Proceeding
Rajasekar, P., Clifford, R., MacIsaac, J., McEwen, L., Kobor, M., & Knox, A. (2017). Use of novel DNA methylation signatures to distinguish between human airway structural cell types

INTRODUCTION: Chronic inflammatory and fibrotic lung diseases like asthma, COPD and pulmonary fibrosis are characterised by modified phenotype of the airway structural cells. Airway walls are comprised of a robust epithelial layer that lines the lume... Read More

Investigating genome wide DNA methylation in bronchial and lung fibroblasts from healthy individuals and individuals with COPD (2017)
Conference Proceeding
Clifford, R., Fishbane, N., Rajasekar, P., MacIsaac, J., McEwen, L., Fisher, A., …Hackett, T. (2017). Investigating genome wide DNA methylation in bronchial and lung fibroblasts from healthy individuals and individuals with COPD

Rationale: Lung fibroblasts are implicated in respiratory disease pathology including chronic obstructive pulmonary disease (COPD). Phenotypic differences between fibroblasts isolated from the bronchi versus the lung parenchyma have been described bu... Read More