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All Outputs (3)

Computational Cardiac Safety Testing (2023)
Book Chapter
Mirams, G. R. (2023). Computational Cardiac Safety Testing. In F. J. Hock, M. R. Gralinski, & M. K. Pugsley (Eds.), Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays (1-33). Springer. https://doi.org/10.1007/978-3-030-73317-9_137-1

In recent years, computational cardiac electrophysiology simulations using mathematical models have begun to be used in industrial and regulatory assessment of the proarrhythmic risk of candidate drug compounds. The aim of this chapter is to equip th... Read More about Computational Cardiac Safety Testing.

Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings (2013)
Book Chapter
Walmsley, J., Mirams, G. R., Efimov, I. R., Burrage, K., & Rodriguez, B. (2013). Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings. In S. Ourselin, D. Rueckert, & N. Smith (Eds.), Functional Imaging and Modeling of the Heart: 7th International Conference, FIMH 2013, London, UK, June 20-22, 2013. Proceedings (224-231). Springer Verlag. https://doi.org/10.1007/978-3-642-38899-6_27

Experimental recordings of transmural activation in the human left ventricle show variability in recorded activation times. In this paper we demonstrate a framework for fitting the conductivity tensor of a monodomain model to reproduce activation tim... Read More about Estimation of Conductivity Tensors from Human Ventricular Optical Mapping Recordings.

Multiscale modeling of colonic crypts and early colorectal cancer (2010)
Book Chapter
Fletcher, A. G., Mirams, G. R., Murray, P. J., Walter, A., Kang, J. W., Cho, K. H., …Byrne, H. M. (2010). Multiscale modeling of colonic crypts and early colorectal cancer. In T. S. Deisboeck, & G. Stamatakos (Eds.), Multiscale Cancer Modeling (111-131). CRC Press. https://doi.org/10.1201/b10407

© 2011 by Taylor & Francis Group, LLC. Colorectal cancer accounts for 13% of all cancers in the United Kingdom, with around 35,300 new diagnoses and 16,000 deaths occurring each year (http://info.cancerresearchuk.org). Colorectal cancer is predomin... Read More about Multiscale modeling of colonic crypts and early colorectal cancer.