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Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression (2025)
Journal Article
Kader, T., Zethoven Sakshi Mahale, M., Saunders, H., Tjoeka, L., Lehmann, R., Jayawardana, M. W., Pang, J.-M., Lesche, D., Rajan, N., Semple, T., Er Amanda Lee, J., Lupat, R., Byrne, D. J., Hughes, S., Nguyen, H., Lai, S., Pechlivanis, M., Craig, O., Devereux, L., House, E., …Gorringe, K. L. (in press). Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression. Journal of Pathology,

Development of ipsilateral breast carcinoma following diagnosis of breast ductal carcinoma in situ (DCIS) has been assumed to represent recurrence of the primary tumour. However, this may not be the case and it is important to know how often recurren... Read More about Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression.

Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies (2025)
Journal Article
Gaston, K., Mohammad, A., Venkatachalapathy, S. V., Notingher, I., Gordon, G. S. D., Arora, A., Rawson, F. J., Grove, J. I., Mukherjee, A., Gomez, D., Jayaraman, P.-S., & Aithal, G. P. (2025). Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies. Cancers, 17(14), Article 2301. https://doi.org/10.3390/cancers17142301

In the management of cholangiocarcinoma, effective biliary drainage and accurate diagnosis are vital to allow further treatment. Confirmation of tissue diagnosis and molecular characterization is also required to guide future treatment options includ... Read More about Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies.

Investigations of Anti‐Reflux Formulations Containing Alginates Using MRI: A Feasibility Study Using Conventional 3.0T and 0.5T Open Upright Scanning (2025)
Journal Article
Hoad, C., Knarr, M., Aliyu, A., Mougin, O., Paul, J., & Marciani, L. (2025). Investigations of Anti‐Reflux Formulations Containing Alginates Using MRI: A Feasibility Study Using Conventional 3.0T and 0.5T Open Upright Scanning. NMR in Biomedicine, 38(8), Article e70090. https://doi.org/10.1002/nbm.70090

Sodium alginates are widely used for their gelling, thickening, and stabilizing properties. Raft-producing formulations havebeen used widely for many years to treat the symptoms of anti-reflux disease and those suffering occasional symptoms. The aimo... Read More about Investigations of Anti‐Reflux Formulations Containing Alginates Using MRI: A Feasibility Study Using Conventional 3.0T and 0.5T Open Upright Scanning.

Ibrutinib and Rituximab versus Immunochemotherapy in previously untreated mantle cell lymphoma: a randomised open label phase II/III superiority trial (2025)
Journal Article
Lewis, D. J., Jerkeman, M., Sorrell, L., Wright, D., Glimelius, I., Poulsen, C. B., Pasanen, A., Rawstron, A., Wader, K. F., Morley, N., Burton, C., Davies, A. J., Lagerlöf, I., Dalal, S., De Tute, R., McNamara, C., Crosbie, N., Toldbod, H. E., Sanders, J., Allgar, V., …Rule, S. (in press). Ibrutinib and Rituximab versus Immunochemotherapy in previously untreated mantle cell lymphoma: a randomised open label phase II/III superiority trial. Lancet,

The effect of oral feeding on gastrointestinal function, motility and appetite- regulating hormones, insulin, glucose and satiety in normal weight individuals and those with obesity (2025)
Journal Article
Simpson, E. J., Althubeati, S., Cordon, S., Hoad, C., Bush, D., Eldeghaidy, S., Gowland, P. A., Macdonald, I. A., & Lobo, D. N. (in press). The effect of oral feeding on gastrointestinal function, motility and appetite- regulating hormones, insulin, glucose and satiety in normal weight individuals and those with obesity. Clinical Nutrition,

Regional profiling reveals a distinct glioblastoma infiltrative margin proteome (2025)
Journal Article
Kocon, A., Smith, S. J., Morentin, B., Callado, L. F., Carter, W., & Rahman, R. (2025). Regional profiling reveals a distinct glioblastoma infiltrative margin proteome. Scientific Reports, 15, Article 24021. https://doi.org/10.1038/s41598-025-09228-z

Isocitrate dehydrogenase wild-type glioblastoma, a malignant brain tumour of glial origin, confers a poor prognosis with a median survival of 12 to 16 months from diagnosis. Glioblastomas are aggressive tumours that rapidly proliferate and diffusely... Read More about Regional profiling reveals a distinct glioblastoma infiltrative margin proteome.

Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation (2025)
Journal Article
Silvey, S., Kamath, P. S., George, J., Choudhury, A., Xie, Q., Topazian, M., Desalgn Mekonnen, H., Cao, Z., Nagral, A., Rajender Reddy, K., Adebayo, D., Asrani, S. K., Rajoriya, N., Arrese, M., Aghayeva, S., Sharma, M., Gonzalez Huezo, S., Gadano, A., Basri Yapici, H., Debzi, N., …Bajaj, J. S. (in press). Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation. Gastroenterology,

Background and aims:
Cirrhosis is a major global burden requiring frequent hospitalizations with a high inpatient mortality. Traditional prognostic tools focused on inpatient mortality are affected by global disparities, which impacts timely manage... Read More about Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation.

Parental Cigarette Smoke Exposure and Its Impact on Offspring Reproductive Health: A Systematic Review of Maternal, Paternal, and Dual-Smoking Effects (2025)
Preprint / Working Paper
Azizbayli, Y., Tatler, A., James, V., Watkins, A., & Fairclough, L. C. (2025). Parental Cigarette Smoke Exposure and Its Impact on Offspring Reproductive Health: A Systematic Review of Maternal, Paternal, and Dual-Smoking Effects

The aim of this systematic review was to evaluate the impact of maternal, paternal and dual-parental cigarette smoke exposure on offspring reproductive health. Original human clinical and animal research studies were included; titles and abstracts we... Read More about Parental Cigarette Smoke Exposure and Its Impact on Offspring Reproductive Health: A Systematic Review of Maternal, Paternal, and Dual-Smoking Effects.

Continuous glucose monitoring and automated insulin delivery systems in the management of diabetes among individuals with chronic kidney disease on dialysis (2025)
Journal Article
Liarakos, A. L., Randhay, A., Wilmot, E. G., & Wilmot, E. G. (in press). Continuous glucose monitoring and automated insulin delivery systems in the management of diabetes among individuals with chronic kidney disease on dialysis. Current Opinion in Nephrology and Hypertension,

Purpose of review: To describe the current evidence and emerging role of continuous glucose monitoring (CGM) and automated insulin delivery (AID) systems in the management of diabetes among individuals with advanced chronic kidney disease (CKD) under... Read More about Continuous glucose monitoring and automated insulin delivery systems in the management of diabetes among individuals with chronic kidney disease on dialysis.

Metastatic spread of pleural mesothelioma to the peritoneum and gallbladder presenting as recurrent acute cholecystitis (2025)
Journal Article
Fouad, M., Zaitoun, A. M., & Lobo, D. N. (2025). Metastatic spread of pleural mesothelioma to the peritoneum and gallbladder presenting as recurrent acute cholecystitis. Oxford Medical Case Reports, 2025(6), Article omaf082. https://doi.org/10.1093/omcr/omaf082

Malignant pleural mesothelioma, a rare, aggressive cancer primarily associated with asbestos exposure, is characterised by poor prognosis and limited treatment options. Distant metastases are uncommon, and peritoneal involvement is rare, while metast... Read More about Metastatic spread of pleural mesothelioma to the peritoneum and gallbladder presenting as recurrent acute cholecystitis.

A Medical Student Curriculum on Functional Medical Disorders (2025)
Journal Article
Butt, M., Scotto, D., Gilmartin, C., Dhali, A., Gonem, S., Singhal, S., Monaghan, T., Frain, J., & Corsetti, M. (2025). A Medical Student Curriculum on Functional Medical Disorders. Clinical Teacher, 22(4), Article e70117. https://doi.org/10.1111/tct.70117

Background

Functional medical disorders (FMDs) refer to persistent physical symptoms that result in impairment or disability, which cannot be diagnosed using routine medical testing. Negative perceptions towards FMDs exist among a variety of heal... Read More about A Medical Student Curriculum on Functional Medical Disorders.

The safety, physiological response, and repeatability of the incremental shuttle walk test in survivors of COVID-19 (2025)
Journal Article
Baldwin, M. M., Daynes, E., Karsanji, U., McAuley, H. J. C., Bishop, N. C., Bolton, C. E., Man, W. D.-C., Vogiatzis, I., Chalmers, J. D., Ho, L.-P., Horsley, A., Marks, M., Poinasamy, K., Ramen, B., Leavy, O. C., Richardson, M., Elneima, O., Shikotra, A., Singapuri, A., Sereno, M., …Singh, S. J. (2025). The safety, physiological response, and repeatability of the incremental shuttle walk test in survivors of COVID-19. ERJ Open Research, Article 00089-2025. https://doi.org/10.1183/23120541.00089-2025

Introduction

The incremental shuttle walk test (ISWT) may be a valuable tool for measuring exercise tolerance in patients after a hospital admission with COVID-19. However, the safety, physiological response, and repeatability of the ISWT is unkno... Read More about The safety, physiological response, and repeatability of the incremental shuttle walk test in survivors of COVID-19.

Macrocyclic transition-metal parashift complexes for MRI at clinical and pre-clinical magnetic fields (2025)
Journal Article
Rogers, N. J., Ashok Kumar, C., Alexander, C., Bowdery, D., Pavlovskaya, G., & Harvey, P. (2025). Macrocyclic transition-metal parashift complexes for MRI at clinical and pre-clinical magnetic fields. Dalton Transactions, 54, 11036-11046. https://doi.org/10.1039/d5dt01149c

A series of macrocyclic transition-metal complexes, including Fe(II), Co(II), Ni(II), and Cu(II) complexes, have been evaluated for parashift MRI imaging applications, by assessing their paramagnetic NMR properties, including proton chemical shifts,... Read More about Macrocyclic transition-metal parashift complexes for MRI at clinical and pre-clinical magnetic fields.

British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025 (2025)
Journal Article
Moran, G. W., Gordon, M., Sinopolou, V., Radford, S. J., Darie, A.-M., Kumar Vuyyuru, S., Alrubaiy, L., Arebi, N., Blackwell, J., Butler, T. D., Chew, T., Cooney, R., De Marco, G., Din, S., Din, S., Feakins, R., Gasparetto, M., Gordon, H., Hansen, R., Kok, K. B., …IBD guideline development group. (2025). British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025. Gut, 74(Suppl 2), s1-s101. https://doi.org/10.1136/gutjnl-2024-334395

In response to recent advancements in inflammatory bowel disease (IBD) management, the British Society of Gastroenterology (BSG) Clinical Services and Standards Committee (CSSC) has commissioned the BSG IBD section to update its guidelines, last revi... Read More about British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025.

Betalain-containing foods and their antitumoral potential: A comprehensive review of in vitro and in vivo evidence (2025)
Journal Article
Martínez-Rodríguez, P., Malo-García, M., Hernández-García, S., Youssefi, S., Nateri, A. S., Guerrero-Rubio, M. A., & Gandía-Herrero, F. (2025). Betalain-containing foods and their antitumoral potential: A comprehensive review of in vitro and in vivo evidence. Trends in Food Science and Technology, 163, Article 105150. https://doi.org/10.1016/j.tifs.2025.105150

Background
The plant pigments betalains have emerged as a family of compounds with nutraceutical potential due to the growing scientific evidence demonstrating their antitumoral capacity.

Scope and approach
The present work aims to analyze decad... Read More about Betalain-containing foods and their antitumoral potential: A comprehensive review of in vitro and in vivo evidence.

Biomarkers of kidney failure and all-cause mortality in chronic kidney disease (2025)
Journal Article
Onoja, A., McDonnell, T., Annessi, I., Banks, R. E., Bergin, M., Cockwell, P., Dusaulcy, R., Fraser, S. D., Johnson, T., Kalra, P. A., Lemaître, B., Saleem, M., Skroblin, P., Soderberg, M., Taal, M. W., Unwin, R. J., Vuilleumier, N., Wheeler, D. C., & Geifman, N. (2025). Biomarkers of kidney failure and all-cause mortality in chronic kidney disease. Journal of the American Society of Nephrology, https://doi.org/10.1681/ASN.0000000767

Background:
Chronic kidney disease (CKD) carries a variable risk for multiple adverse outcomes, highlighting the need for a personalised approach. This study evaluated several novel biomarkers linked to key disease mechanisms to predict the risk of... Read More about Biomarkers of kidney failure and all-cause mortality in chronic kidney disease.

An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes (2025)
Journal Article
Khan, S., Karmokar, A., Howells, L., Britton, R. G., Parrott, E., Palacios-Gallego, R., Tufarelli, C., Cai, H., Higgins, J., Sylvius, N., West, K., McGregor, A., Moore, D., Burgess, S. G., Richards, M. W., Winter, A., Sidat, Z., Foreman, N., Hoorn, S. T., Vermeulen, L., …Brown, K. (2025). An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes. Cancer Letters, 629, Article 217885. https://doi.org/10.1016/j.canlet.2025.217885

The cost of cancer care globally is unsustainable and strategies to reduce the mounting burden of cancer are urgently needed. One approach is the use of preventive therapies to reduce cancer risk; dietary-derived compounds with good safety profiles r... Read More about An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes.

A survey on knowledge about PROcedure-SPEcific Postoperative Pain ManagemenT (PROSPECT) Recommendations (2025)
Journal Article
Joshi, G. P., Wu, C. L., Moka, E., Van de Velde, M., Lobo, D. N., Albrecht, E., Bugada, D., Beloeil, H., Bonnet, M.-P., Desai, N., Dewinter, G., Freys, S. M., Kehlet, H., Lavand’homme, P., Pogatzki-Zahn, E. M., Raeder, J., Rawal, N., & Sauter, A. R. (in press). A survey on knowledge about PROcedure-SPEcific Postoperative Pain ManagemenT (PROSPECT) Recommendations. European Journal of Anaesthesiology,