Research Repository

See what's under the surface


Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers (2019)
Journal Article
Madeira Do O, J., Foralosso, R., Yilmaz, G., Mastrotto, F., King, P. J. S., Xerri, R. M., …Mantovani, G. (in press). Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers. Nanoscale,

Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with fine-tuned balance between hydrophilic sugar pendant units and relatively... Read More

Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines (2019)
Journal Article
Ali Ali, E., Kalli, M., Wan, D., Nakamura, R., Onion, D., Alanine, D. G., …Falcone, F. H. (2019). Characterization of human FcεRIα chain expression and gene copy number in humanized rat basophilic leukaemia (RBL) reporter cell lines. PLoS ONE, 14(8), https://doi.org/10.1371/journal.+pone.0221034

Several laboratories have created rat basophil leukemia (RBL) cell lines stably transfected with the human high affinity IgE receptor (FcεRI H). More recently, humanized RBL cell lines saw the introduction of reporter genes such as luciferase (RS-ATL... Read More

Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments (2019)
Journal Article
O’Brien, D. M., Vallieres, C., Alexander, C., Howdle, S. M., Stockman, R. A., & Avery, S. V. (2019). Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments. Journal of Materials Chemistry B, doi:10.1039/c9tb00878k

A bis-epoxide monomer was synthesised in two steps from (R)-carvone, a terpenoid renewable feedstock derived from spearmint oil, and used to prepare β-aminoalcohol oligomers in polyaddition reactions with bis-amines without requiring solvent or catal... Read More

Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles (2019)
Journal Article
Vasey, C. E., Pearce, A. K., Sodano, F., Cavanagh, R., Abelha, T., Cuzzucoli Crucitti, V., …Alexander, C. (2019). Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles. Biomaterials Science, 7(9), 3832-3845. doi:10.1039/c9bm00667b

In order for synthetic polymers to find widespread practical application as biomaterials, their syntheses must be easy to perform, utilising freely available building blocks, and should generate products which have no adverse effects on cells or tiss... Read More

Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study (2019)
Journal Article
West, J., Otete, H., Sultan, A. A., & Crooks, C. J. (2019). Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study. Epidemiology, 30(4), e23-e24. doi:10.1097/EDE.0000000000001006

The diagnosis rates of coeliac disease differ substantially between countries. Intriguingly, there has been recent evidence from Olmstead County, USA and Finland that in the last 5-10 years incidence has plateaued or even declined. In most population... Read More

Molecular phenotyping of the surfaceome of migratory chondroprogenitors and mesenchymal stem cells using biotinylation, glycocapture and quantitative LC-MS/MS proteomic analysis (2019)
Journal Article
Matta, C., Boocock, D. J., Fellows, C. R., Miosge, N., Dixon, J. E., Liddell, S., …Mobasheri, A. (2019). Molecular phenotyping of the surfaceome of migratory chondroprogenitors and mesenchymal stem cells using biotinylation, glycocapture and quantitative LC-MS/MS proteomic analysis. Scientific Reports, 9, doi:10.1038/s41598-019-44957-y

Polymer microparticles with defined surface chemistry and topography mediate the formation of stem cell aggregates and cardiomyocyte function (2019)
Journal Article
Alvarez-Paino, M., Amer, M. H., Nasir, A., Cuzzucoli Crucitti, V., Needham, D., Denning, C., …Alexander, C. (2019). Polymer microparticles with defined surface chemistry and topography mediate the formation of stem cell aggregates and cardiomyocyte function. ACS Applied Materials and Interfaces, doi:10.1021/acsami.9b04769

Surface-functionalized microparticles are relevant to fields spanning engineering and biomedicine, with uses ranging from cell culture to advanced cell delivery. Varying topographies of biomaterial surfaces are also being investigated as mediators of... Read More

Controlling the preferential motion of chiral molecular walkers on a surface (2019)
Journal Article
Abbasi-Pérez, D., Sang, H., Pérez-García, L., Floris, A., Amabilino, D. B., Raval, R., …Kantorovich, L. (2019). Controlling the preferential motion of chiral molecular walkers on a surface. Chemical Science, doi:10.1039/c9sc01135h

Molecular walkers standing on two or more “feet” on an anisotropic periodic potential of a crystal surface may perform a one-dimensional Brownian motion at the surface-vacuum interface along a particular direction in which their mobility is the large... Read More

Tripodal O-N-O bis-Phenolato Amine Titanium(IV) Complexes Show High In Vitro Anti-Cancer Activity (2019)
Journal Article
Abid, M., Nouch, R., Bradshaw, T. D., Lewis, W., & Woodward, S. (2019). Tripodal O-N-O bis-Phenolato Amine Titanium(IV) Complexes Show High In Vitro Anti-Cancer Activity. European Journal of Inorganic Chemistry, doi:10.1002/ejic.201900510

The octahedral titanium(IV) complexes trans,mer‐[Ti{R3N(CH2C6H2‐2‐O‐4‐R2‐6‐R1)2}2] (R1 = Me, OMe, Cl; R2 = Me, OMe, F, Cl; R3 = Me, Et; not all combinations) are synthesised in two steps from simple phenols in 36‐53% overall yield. The highly crystal... Read More

3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells (2019)
Journal Article
Prasopthum, A., Cooper, M., Shakesheff, K. M., & Yang, J. (2019). 3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells. ACS Applied Materials and Interfaces, 11(21), 18896-18906. doi:10.1021/acsami.9b01472

The effect of topography in 3D printed polymer scaffolds on stem cell differentiation is a significantly under-explored area. Compared to 2D biomaterials on which various well-defined topographies have been incorporated and been shown to direct an ar... Read More

Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates (2019)
Journal Article
Xie, S., Li, X., Yu, H., Zhang, P., Wang, J., Wang, C., …Xu, J. (2019). Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates. Bioorganic and Medicinal Chemistry, 27(13), 2764-2770. doi:10.1016/j.bmc.2019.05.004

7,8 Dihydroxy 3 methyl isochromanone 4 XJP is a polyphenolic natural product with moderate antihypertensive activity. T o obtain new agents with stronger potency and safer profile , we employed XJP and naftopidil as the lead compound s t o design and... Read More

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib (2019)
Journal Article
Morgan, J., Saleem, M., Ng, R., Armstrong, C., Wong, S. S., Caulton, S. G., …Emsley, J. (2019). Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. Blood Advances, 3(9), 1450-1459. doi:10.1182/bloodadvances.2018027011

Cell-surface receptor interactions between leukocyte integrin macrophage-1 antigen (Mac-1, also known as CR3, aMb2, CD11b/CD18) and platelet glycoprotein Iba (GPIba) are critical to vascular inflammation. To define the key residues at the binding inter... Read More

Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX (2019)
Journal Article
Al-Ani, A. W., Zhang, L., Ferreira, L., Turyanska, L., Bradshaw, T. D., & Thomas, N. R. (2019). Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX. Nanomedicine: Nanotechnology, Biology and Medicine, 20, doi:10.1016/j.nano.2019.04.008

Listeria innocua DNA binding protein from starved cells (LiDps) belongs to the ferritin family and provides a promising self-assembling spherical 12-mer protein scaffold for the generation of functional nanomaterials. We report the creation of a Gaus... Read More

Cultural intelligence of MPharm undergraduates (2019)
Journal Article
Alosaimi, N., Boyd, M., & Boardman, H. (2019). Cultural intelligence of MPharm undergraduates. International Journal of Pharmacy Practice, 27(S2), 27-28. doi:10.1111/ijpp.12533

The chemical throwing power of lithium-based inhibitors from organic coatings on AA2024-T3 (2019)
Journal Article
Visser, P., Marcoen, K., Trindade, G. F., Abel, M., Watts, J. F., Hauffman, T., …Terryn, H. (2019). The chemical throwing power of lithium-based inhibitors from organic coatings on AA2024-T3. Corrosion Science, 150, 194-206. doi:10.1016/j.corsci.2019.02.009

Chemical throwing power, being the distance over which an inhibitor is able to protect a defect effectively, is an important parameter for active protective coatings. This study investigates the chemical throwing power of lithium-based leachable corr... Read More

Synthesis of methacrylate-terminated block copolymers with reduced transesterification by controlled ring-opening polymerization (2018)
Journal Article
Ruiz-Cantu, L. A., Pearce, A. K., Burroughs, L., Bennett, T. M., Vasey, C. E., Wildman, R., …Taresco, V. (2019). Synthesis of methacrylate-terminated block copolymers with reduced transesterification by controlled ring-opening polymerization. Macromolecular Chemistry and Physics, 220(2), doi:10.1002/macp.201800459

This work presents a robust method to achieve the synthesis of low molecular weight polyesters 26 via ring-opening polymerization (ROP) initiated by 2-hydroxyethyl-methacrylate (HEMA) 27 when using triazabicyclodecene (TBD) as catalyst. The effect th... Read More

Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS (2018)
Journal Article
Dahabiyeh, L. A., Tooth, D., Carrell, R. W., Read, R. J., Yan, Y., Pipkin, F. B., & Barrett, D. A. (2019). Measurement of the total angiotensinogen and its reduced and oxidised forms in human plasma using targeted LC-MS/MS. Analytical and Bioanalytical Chemistry, 411(2), 427–437. doi:10.1007/s00216-018-1455-2

Angiotensinogen (AGT) is a critical protein in the renin-angiotensin-aldosterone system and may have an important role in the pathogenesis of pre-eclampsia. The disulphide linkage between cysteines 18 and 138 has a key role in the redox switch of AGT... Read More

The central region of CNOT1 and CNOT9 stimulate deadenylation by the Ccr4 Not nuclease module (2018)
Journal Article
Pavanello, L., Hall, B., Airhihen, B., & Winkler, G. S. (2018). The central region of CNOT1 and CNOT9 stimulate deadenylation by the Ccr4 Not nuclease module. Biochemical Journal, 475(21), 3437–3450. doi:10.1042/bcj20180456

Regulated degradation of cytoplasmic mRNA is important for the accurate execution of gene expression programmes in eukaryotic cells. A key step in this process is the shortening and removal of the mRNA poly(A) tail, which can be achieved by the recru... Read More

Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging (2018)
Journal Article
Nizamudeen, Z., Markus, R., Lodge, R., Parmenter, C., Platt, M., Chakrabarti, L., & Sottile, V. (2018). Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(12), 1891-1900. doi:10.1016/j.bbamcr.2018.09.008

Extracellular vesicles (EVs) have prevalent roles in cancer biology and regenerative medicine. Conventional techniques for characterising EVs including electron microscopy (EM), nanoparticle tracking analysis (NTA) and tuneable resistive pulse sensin... Read More