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The role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review (2019)
Journal Article
Chadborn, N., Goodman, C., Zubair, M., Sousa, L., Gladman, J., Dening, T., & Gordon, A. (in press). The role of comprehensive geriatric assessment in healthcare of older people in UK care homes: realist review. BMJ Open,

Objectives Comprehensive Geriatric Assessment (CGA) may be a way to deliver optimal care for care home residents. We used realist review to develop a theory-driven account of how CGA works in care homes. Design Realist review Setting Care ho... Read More

Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss (2019)
Journal Article
Heffernan, E., Habib, A., & Ferguson, M. (2019). Evaluation of the psychometric properties of the Social Isolation Measure (SIM) in adults with hearing loss. International Journal of Audiology, 58(1), 45-52. doi:10.1080/14992027.2018.1533257

This study aimed to evaluate the psychometric properties of a brief, hearing-specific outcome measure: the Social Isolation Measure (SIM). In Phase 1, adults with hearing loss were invited to complete an online survey that contained the SIM, a hearin... Read More

Impaired forward model updating in young adults with Tourette syndrome (2018)
Journal Article
Kim, S., Jackson, G. M., Dyke, K., & Jackson, S. R. (2019). Impaired forward model updating in young adults with Tourette syndrome. Brain, 142(1), 209-219. doi:10.1093/brain/awy306

Current theories of motor control emphasise how the brain may use internal models of the body to ensure accurate planning and control of movements. One such internal model - a forward model - is thought to generate an estimate of the next motor state... Read More

Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients (2018)
Journal Article
Bradley, C., Scott, R., Cox, E., Palaniyappan, N., Thompson, B., Ryder, D., …Francis, S. (2018). Short-term changes observed in multi-parametric liver MRI following therapy with direct acting antivirals in chronic hepatitis C virus patients. European Radiology, doi:10.1007/s00330-018-5788-1

Methods: We applied multiparametric MRI to assess changes in liver composition, perfusion and blood flow in 17 patients before DAA therapy and after treatment completion (within 12 weeks of last DAA tablet swallowed). Results: We observed changes in... Read More

Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial (2018)
Journal Article
Hull, M. A., Sprange, K., Hepburn, T., Tan, W., Shafayat, A., Rees, C. J., …seAFOod Collaborative Group, . (2018). Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): a multicentre, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial. Lancet, doi:10.1016/s0140-6736(18)31775-6

Background: The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) and aspirin both have proof of concept for colorectal cancer chemoprevention, aligned with an excellent safety profile. Therefore, we aimed to test the efficacy of EPA and... Read More

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
GBD 2017 SDG Collaborators, , Bisanzio, D., & Shokraneh, F. (2018). Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 2091-2138. doi:10.1016/S0140-6736(18)32281-5

Background: Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of " leavin... Read More

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
GBD 2017 Disease and Injury Incidence and Prevalence Collaborators, , Bisanzio, D., & Shokraneh, F. (2018). Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1789-1858. doi:10.1016/S0140-6736(18)32279-7

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990... Read More

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
GBD 2017 Causes of Death Collaborators, , Bisanzio, D., & Shokraneh, F. (2018). Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1736-1788. doi:10.1016/S0140-6736(18)32203-7

Background: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, natio... Read More

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
GBD 2017 DALYs and HALE Collaborators, , Bisanzio, D., Shokraneh, F., & Williams, H. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1859-1922. doi:10.1016/S0140-6736(18)32335-3

Background: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services... Read More

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Stu (2018)
Journal Article
GBD 2017 Risk Factor Collaborators, , Bisanzio, D., & Shokraneh, F. (2018). Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1923-1994. doi:10.1016/S0140-6736(18)32225-6

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–o... Read More

Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017 (2018)
Journal Article
GBD 2017 Population and Fertility Collaborators, , & Shokraneh, F. (2018). Population and fertility by age and sex for 195 countries and territories, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet, 392(10159), 1995-2051. doi:10.1016/S0140-6736(18)32278-5

Background: Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility... Read More

Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity? (2018)
Journal Article
Rowland, S. C., Hartley, D. E. H., & Wiggins, I. M. (2018). Listening in naturalistic scenes: what can functional near-infrared spectroscopy and intersubject correlation analysis tell us about the underlying brain activity?. Trends in Hearing, 22, (1-18). doi:10.1177/2331216518804116. ISSN 2331-2165

Listening to speech in the noisy conditions of everyday life can be effortful, reflecting the increased cognitive workload involved in extracting meaning from a degraded acoustic signal. Studying the underlying neural processes has the potential to p... Read More

Early discharge and rehabilitation in paediatric acquired brain and neurological injury: a transferable model (2018)
Journal Article
Keetley, R., Kelly, L., Whitehouse, W. P., Thomas, S., Bennett, E., Chow, G., …Williams, J. (2018). Early discharge and rehabilitation in paediatric acquired brain and neurological injury: a transferable model. Archives of Disease in Childhood.education and Practice Edition, doi:10.1136/archdischild-2018-315096

Children and young people who require rehabilitation following sustaining an acquired brain injury often experience long lengths of stay (LOS) and potentially poorer recovery outcomes due to limited access to therapy and little proactive discharge pl... Read More

MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis (2018)
Journal Article
Cox, E. F., Palaniyappan, N., Aithal, G. P., Guha, I. N., & Francis, S. T. (2018). MRI assessment of altered dynamic changes in liver haemodynamics following a meal challenge in compensated cirrhosis. European Radiology Experimental, 2, doi:10.1186/s41747-018-0056-3. ISSN 2509-9280

Background: To use magnetic resonance imaging (MRI) to dynamically assess postprandial changes in hepatic and collateral blood flow, liver perfusion and oxygenation in healthy participants and patients with liver disease with compensated cirrhosis (C... Read More

Extending the Human Connectome Project across ages: imaging protocols for the Lifespan Development and Aging projects (2018)
Journal Article
Harms, M. P., Somerville, L. H., Ances, B. M., Andersson, J., Barch, D. M., Bastiani, M., …Yacoub, E. (2018). Extending the Human Connectome Project across ages: imaging protocols for the Lifespan Development and Aging projects. NeuroImage, 183, (972-984). doi:10.1016/j.neuroimage.2018.09.060. ISSN 1095-9572

The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-sta... Read More

Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors (2018)
Journal Article
Servante, J., Estranero, J., Meijer, L., Layfield, R., & Grundy, R. (2018). Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors. Oncotarget, 9(81), 35266-35277. doi:10.18632/oncotarget.26186

Brain tumors are the leading cause of cancer-related death in children and are the most challenging childhood cancer in relation to diagnosis, treatment, and outcome. One potential novel strategy to improve outcomes in cancer involves the manipulati... Read More

Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells (2018)
Journal Article
Alkhattabi, N., Todd, I., Negm, O., Tighe, P. J., & Fairclough, L. C. (2018). Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells. Toxicology Letters, 299, (40-46). doi:10.1016/j.toxlet.2018.09.002. ISSN 0378-4274

Cigarette smoke has significant toxic effects on the immune system, and increases the risk of developing autoimmune diseases; one immunosuppressive effect of cigarette smoke is that it inhibits the T cell-stimulating, immunogenic properties of myeloi... Read More

The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing (2018)
Journal Article
Labisso, W., Raulin, A., Nwidu, L., Kocon, A., Wayne, D., Erdozain, A., …Carter, W. (2018). The loss of α- and β-tubulin proteins are a pathological hallmark of chronic alcohol consumption and natural brain ageing. Brain Sciences, 8(9), doi:10.3390/brainsci8090175

Repetitive excessive alcohol intoxication leads to neuronal damage and brain shrinkage. We examined cytoskeletal protein expression in human post-mortem tissue from Brodmann’s area 9 of the prefrontal cortex (PFC). Brain samples from 44 individuals w... Read More

Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment (2018)
Journal Article
Meng, D., Li, X., Bauer, M., Taylor, J., Auer, D. P., & Alzheimer's Disease Neuroimaging Initiative, . (2018). Altered nucleus basalis connectivity predicts treatment response in mild cognitive impairment. Radiology, 2018, doi:10.1148/radiol.2018180092

Purpose: To determine whether functional connectivity (FC) mapping of nucleus basalis of Meynert (NBM) cholinergic network (hereafter, NBM FC) could provide a biomarker of central cholinergic deficits with predictive potential for response to choline... Read More

Visuomotor learning and unlearning in children and adolescents with Tourette syndrome (2018)
Journal Article
Kim, S., Jackson, S. R., Groom, M., & Jackson, G. M. (2018). Visuomotor learning and unlearning in children and adolescents with Tourette syndrome. Cortex, 109, 50-59. doi:10.1016/j.cortex.2018.08.007

Tourette syndrome (TS) is a childhood-onset neurological condition characterised by an evolving repertoire of chronic motor tics and one or more phonic tics. Tics, like habits, are inflexible and repetitive behaviours that are acquired over a period... Read More