Research Repository

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Developing a sustainable route to environmentally relevant metal-organic frameworks: ultra-rapid synthesis of MFM-300(Al) using microwave heating (2019)
Journal Article
Thomas-Hillman, I., Stevens, L. A., Lange, M., Möllmer, J., Lewis, W., Dodds, C., …Laybourn, A. (2019). Developing a sustainable route to environmentally relevant metal-organic frameworks: ultra-rapid synthesis of MFM-300(Al) using microwave heating. Green Chemistry, doi:10.1039/c9gc02375e

NO2, SO2 and CO2 are major air pollutants causing significant environmental and health problems. Metal-organic frameworks (MOFs), in particular [Al2(OH)2(C16O8H6)](H2O)6 (trivial names: NOTT-300/MFM-300(Al)), have shown great promise for capturing th... Read More

Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments (2019)
Journal Article
O’Brien, D. M., Vallieres, C., Alexander, C., Howdle, S. M., Stockman, R. A., & Avery, S. V. (2019). Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments. Journal of Materials Chemistry B, doi:10.1039/c9tb00878k

A bis-epoxide monomer was synthesised in two steps from (R)-carvone, a terpenoid renewable feedstock derived from spearmint oil, and used to prepare β-aminoalcohol oligomers in polyaddition reactions with bis-amines without requiring solvent or catal... Read More

PepFoot: a software package for semiautomated processing of protein footprinting data (2019)
Journal Article
Bellamy-Carter, J., & Oldham, N. J. (2019). PepFoot: a software package for semiautomated processing of protein footprinting data. Journal of Proteome Research, doi:10.1021/acs.jproteome.9b00238

Covalent footprinting of proteins using reactive intermediates such as radicals and carbenes is emerging as a valuable tool for mapping surface accessibility, and hence binding sites of proteins. The approach generates a significant amount of mass sp... Read More

Controlling the preferential motion of chiral molecular walkers on a surface (2019)
Journal Article
Abbasi-Pérez, D., Sang, H., Pérez-García, L., Floris, A., Amabilino, D. B., Raval, R., …Kantorovich, L. (2019). Controlling the preferential motion of chiral molecular walkers on a surface. Chemical Science, doi:10.1039/c9sc01135h

Molecular walkers standing on two or more “feet” on an anisotropic periodic potential of a crystal surface may perform a one-dimensional Brownian motion at the surface-vacuum interface along a particular direction in which their mobility is the large... Read More

The nature of proton shuttling in protic ionic liquid fuel cells (2019)
Journal Article
Smith, D. E., & Walsh, D. A. (2019). The nature of proton shuttling in protic ionic liquid fuel cells. Advanced Energy Materials, doi:10.1002/aenm.201900744

It has been proposed previously that protic ionic liquids (PILs) such as diethylmethylammonium triflate could be used as the electrolytes in nonhumidified, intermediate temperature H2 fuel cells, potentially offering the prospect of high conductivity... Read More

3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells (2019)
Journal Article
Prasopthum, A., Cooper, M., Shakesheff, K. M., & Yang, J. (2019). 3D printed scaffolds with controlled micro-/nano- porous surface topography direct chondrogenic and osteogenic differentiation of mesenchymal stem cells. ACS Applied Materials and Interfaces, 11(21), 18896-18906. doi:10.1021/acsami.9b01472

The effect of topography in 3D printed polymer scaffolds on stem cell differentiation is a significantly under-explored area. Compared to 2D biomaterials on which various well-defined topographies have been incorporated and been shown to direct an ar... Read More

Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib (2019)
Journal Article
Morgan, J., Saleem, M., Ng, R., Armstrong, C., Wong, S. S., Caulton, S. G., …Emsley, J. (2019). Structural basis of the leukocyte integrin Mac-1 I-domain interactions with the platelet glycoprotein Ib. Blood Advances, 3(9), 1450-1459. doi:10.1182/bloodadvances.2018027011

Cell-surface receptor interactions between leukocyte integrin macrophage-1 antigen (Mac-1, also known as CR3, aMb2, CD11b/CD18) and platelet glycoprotein Iba (GPIba) are critical to vascular inflammation. To define the key residues at the binding inter... Read More

Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX (2019)
Journal Article
Al-Ani, A. W., Zhang, L., Ferreira, L., Turyanska, L., Bradshaw, T. D., & Thomas, N. R. (2019). Listeria innocua Dps as a nanoplatform for bioluminescence based photodynamic therapy utilizing Gaussia princeps luciferase and zinc protoporphyrin IX. Nanomedicine: Nanotechnology, Biology and Medicine, 20, doi:10.1016/j.nano.2019.04.008

Listeria innocua DNA binding protein from starved cells (LiDps) belongs to the ferritin family and provides a promising self-assembling spherical 12-mer protein scaffold for the generation of functional nanomaterials. We report the creation of a Gaus... Read More

Probing elusive cations: infrared spectroscopy of protonated acetic acid (2019)
Journal Article
Davies, J. A., Besley, N. A., Yang, S., & Ellis, A. M. (2019). Probing elusive cations: infrared spectroscopy of protonated acetic acid. Journal of Physical Chemistry Letters, 10, 2108-2112. doi:10.1021/acs.jpclett.9b00767

Protonated carboxylic acids, (RCOOH)H+, are the initial intermediates in acid-catalyzed (Fischer) esterification reactions. However the identity of the isomeric form is under debate. Surprisingly, no optical spectra have been reported for any isomer... Read More

Turning the periodic table upside down (2019)
Journal Article
Poliakoff, M., Makin, A. D. J., Tang, S. L. Y., & Poliakoff, E. (2019). Turning the periodic table upside down. Nature Chemistry, doi:10.1038/s41557-019-0253-6

The periodic table is immensely powerful for rationalizing many different properties of the chemical elements, but would turning it on its head make some important aspects easier to understand and give everyone a new perspective on chemistry?

Combining continuous flow oscillatory baffled reactors and microwave heating: process intensification and accelerated synthesis of metal-organic frameworks (2018)
Journal Article
Laybourn, A., López-Fernández, A. M., Thomas-Hillman, I., Katrib, J., Lewis, W., Dodds, C., …Kingman, S. W. (2018). Combining continuous flow oscillatory baffled reactors and microwave heating: process intensification and accelerated synthesis of metal-organic frameworks. Chemical Engineering Journal, doi:10.1016/j.cej.2018.09.011

We have constructed a continuous flow oscillatory baffled reactor (CF-OBR) equipped with a homogeneous and controllable microwave applicator in an entirely novel design. This affords a new route to chemical production incorporating many of the princi... Read More

Formation of hollow carbon nanoshells from thiol stabilised silver nanoparticles via heat treatment (2018)
Journal Article
Watts, J. A., Fay, M. W., Rance, G. A., Brown, P. D., & Khlobystov, A. N. (2018). Formation of hollow carbon nanoshells from thiol stabilised silver nanoparticles via heat treatment. Carbon, 139, 538-544. doi:10.1016/j.carbon.2018.06.074

Uniform, less 10 nm sized, hollow carbon nano-shells (HCNS) have been prepared via a single-step, thermal treatment of alkanethiol stabilised Ag nanoparticles (TS-AgNP). Direct evidence for the formation of spherical HCNS from TS-AgNP is provided by... Read More

Carbene in cupredoxin protein scaffolds: replacement of a histidine ligand in the active site substantially alters copper redox properties (2018)
Journal Article
Planchestainer, M., Segaud, N., Shanmugam, M., McMaster, J., Paradisi, F., & Albrecht, M. (2018). Carbene in cupredoxin protein scaffolds: replacement of a histidine ligand in the active site substantially alters copper redox properties. Angewandte Chemie International Edition, 57(33), (10677-10682). doi:10.1002/anie.201807168. ISSN 1433-7851

N-heterocyclic carbene (NHC) ligands have had a major impact in homogeneous catalysis, however, their potential role in biological systems is essentially unexplored. Here we replaced a copper-coordinating histidine (His) in the active site of azurin... Read More

Tuning the electronic structure of organic–inorganic hybrid polyoxometalates: The crucial role of the covalent linkage (2018)
Journal Article
Kibler, A. J., & Newton, G. N. (2018). Tuning the electronic structure of organic–inorganic hybrid polyoxometalates: The crucial role of the covalent linkage. Polyhedron, 154, 1-20. doi:10.1016/j.poly.2018.06.027

The covalent organofunctionalization of polyoxometalates (POMs) has been widely used to both control and enhance their redox properties, particularly for applications in catalysis, energy storage, optics and molecular magnetism. The design of such sy... Read More

Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters (2018)
Journal Article
Karad, S. N., Panchal, H., Clarke, C., Lewis, W., & Lam, H. W. (2018). Enantioselective synthesis of chiral cyclopent-2-enones by nickel-catalyzed desymmetrization of malonate esters. Angewandte Chemie International Edition, 57(29), (9122-9125). doi:10.1002/anie.201805578. ISSN 1433-7851

The enantioselective synthesis of highly functionalized chiral cyclopent‐2‐enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline... Read More

The role of adsorbed ions during electrocatalysis in ionic liquids (2014)
Journal Article
Ejigu, A., & Walsh, D. A. (2014). The role of adsorbed ions during electrocatalysis in ionic liquids. Journal of Physical Chemistry C, 118(14), (7414-7422). doi:10.1021/jp411730z. ISSN 1932-7447

The effects of electrode–adsorbate interactions on electrocatalysis at Pt in ionic liquids are described. The ionic liquids are diethylmethylammonium trifluoromethanesulfonate, [dema][TfO], dimethylethylammonium trifluoromethanesulfonate, [dmea][TfO]... Read More